TY - JOUR
T1 - Glucose-lowering drugs to reduce cardiovascular risk in type 2 diabetes
AU - Kalyani, Rita R.
N1 - Publisher Copyright:
Copyright © 2021 Massachusetts Medical Society.
PY - 2021/4/1
Y1 - 2021/4/1
N2 - A 64-year-old woman with a 10-year history of type 2 diabetes presents for a routine wellness visit. She had a myocardial infarction 4 years ago and has well-controlled hypertension and dyslipidemia. Her medications include 2000 mg of metformin daily, losartan, hydrochlorothiazide, high-intensity atorvastatin, and aspirin. She does not monitor her blood glucose levels routinely at home. On examination, her blood pressure is 128/75 mm Hg and her body-mass index (the weight in kilograms divided by the square of the height in meters) is 33. Her glycated hemoglobin level is 7.9%, total cholesterol level 155 mg per deciliter (4.0 mmol per liter), high-density lipoprotein cholesterol level 52 mg per deciliter (1.34 mmol per liter), triglyceride level 126 mg per deciliter (1.4 mmol per liter), and low-density lipoprotein cholesterol level 78 mg per deciliter (2.0 mmol per liter). The estimated glomerular filtration rate is 76 ml per minute per 1.73 m2 of body-surface area, and the urinary albumin-to-creatinine ratio (with albumin measured in milligrams and creatinine in grams) is 25. She has no retinopathy or neuropathy. She has heard that certain medications for diabetes can reduce her risk of cardiovascular disease. What would you advise?
AB - A 64-year-old woman with a 10-year history of type 2 diabetes presents for a routine wellness visit. She had a myocardial infarction 4 years ago and has well-controlled hypertension and dyslipidemia. Her medications include 2000 mg of metformin daily, losartan, hydrochlorothiazide, high-intensity atorvastatin, and aspirin. She does not monitor her blood glucose levels routinely at home. On examination, her blood pressure is 128/75 mm Hg and her body-mass index (the weight in kilograms divided by the square of the height in meters) is 33. Her glycated hemoglobin level is 7.9%, total cholesterol level 155 mg per deciliter (4.0 mmol per liter), high-density lipoprotein cholesterol level 52 mg per deciliter (1.34 mmol per liter), triglyceride level 126 mg per deciliter (1.4 mmol per liter), and low-density lipoprotein cholesterol level 78 mg per deciliter (2.0 mmol per liter). The estimated glomerular filtration rate is 76 ml per minute per 1.73 m2 of body-surface area, and the urinary albumin-to-creatinine ratio (with albumin measured in milligrams and creatinine in grams) is 25. She has no retinopathy or neuropathy. She has heard that certain medications for diabetes can reduce her risk of cardiovascular disease. What would you advise?
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U2 - 10.1056/NEJMcp2000280
DO - 10.1056/NEJMcp2000280
M3 - Article
C2 - 33789013
AN - SCOPUS:85103597746
SN - 0028-4793
VL - 384
SP - 1248
EP - 1260
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 13
ER -