Abstract
This study was designed to evaluate the feasibility of assessing myocardial viability using glucose loading followed by 201Tl SPECT. Methods: First, the effect of insulin on the kinetics of 201Tl uptake was evaluated in isolated perfused rat hearts. Second, glucose-loading 201Tl myocardial SPECT was performed in 13 nondiabetic patients with histories of anterior myocardial infarction. Thirty minutes before acquiring rest 201Tl SPECT, 20 g of glucose were intravenously injected into the fasting subjects. Thallium perfusion defects were compared to those of conventional rest- redistribution SPECT images obtained within a 2-wk interval. SPECT images were divided into 21 segments, and a defect score in 17 segments was calculated as a sum of the semiquantitative defect scores (0 = normal; I = mildly decreased uptake; 2 = severely decreased uptake; 3 = absence of uptake). Results: Thallium-201 uptake in isolated hearts showed a significant increase of 26% after insulin loading. Eleven (24%) of 45 segments showing perfusion defects on the conventional rest SPECT images demonstrated 201Tl uptake on glucose-loading SPECT imaging. Defect scores decreased significantly on the glucose-loading SPECT images (9.9 ± 2.2 in early images; mean ± s.e.) compared with the conventional rest-redistribution SPECT images (12.6 ± 6.9 in delayed images, p <0.05). Conclusion: Glucose- loading SPECT represents a superior method for assessing myocardial viability using 201Tl.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 573-577 |
| Number of pages | 5 |
| Journal | Journal of Nuclear Medicine |
| Volume | 38 |
| Issue number | 4 |
| State | Published - 1997 |
| Externally published | Yes |
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Keywords
- glucose loading
- hibernating myocardium
- myocardial SPECT
- thallium-201
ASJC Scopus subject areas
- Radiological and Ultrasound Technology
Cite this
Glucose-loading thallium-201 myocardial SPECT. / Chiba, Hiroshi; Kusuoka, Hideo; Ohno, Joichi; Nishimura, Tsunehiko.
In: Journal of Nuclear Medicine, Vol. 38, No. 4, 1997, p. 573-577.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Glucose-loading thallium-201 myocardial SPECT
AU - Chiba, Hiroshi
AU - Kusuoka, Hideo
AU - Ohno, Joichi
AU - Nishimura, Tsunehiko
PY - 1997
Y1 - 1997
N2 - This study was designed to evaluate the feasibility of assessing myocardial viability using glucose loading followed by 201Tl SPECT. Methods: First, the effect of insulin on the kinetics of 201Tl uptake was evaluated in isolated perfused rat hearts. Second, glucose-loading 201Tl myocardial SPECT was performed in 13 nondiabetic patients with histories of anterior myocardial infarction. Thirty minutes before acquiring rest 201Tl SPECT, 20 g of glucose were intravenously injected into the fasting subjects. Thallium perfusion defects were compared to those of conventional rest- redistribution SPECT images obtained within a 2-wk interval. SPECT images were divided into 21 segments, and a defect score in 17 segments was calculated as a sum of the semiquantitative defect scores (0 = normal; I = mildly decreased uptake; 2 = severely decreased uptake; 3 = absence of uptake). Results: Thallium-201 uptake in isolated hearts showed a significant increase of 26% after insulin loading. Eleven (24%) of 45 segments showing perfusion defects on the conventional rest SPECT images demonstrated 201Tl uptake on glucose-loading SPECT imaging. Defect scores decreased significantly on the glucose-loading SPECT images (9.9 ± 2.2 in early images; mean ± s.e.) compared with the conventional rest-redistribution SPECT images (12.6 ± 6.9 in delayed images, p <0.05). Conclusion: Glucose- loading SPECT represents a superior method for assessing myocardial viability using 201Tl.
AB - This study was designed to evaluate the feasibility of assessing myocardial viability using glucose loading followed by 201Tl SPECT. Methods: First, the effect of insulin on the kinetics of 201Tl uptake was evaluated in isolated perfused rat hearts. Second, glucose-loading 201Tl myocardial SPECT was performed in 13 nondiabetic patients with histories of anterior myocardial infarction. Thirty minutes before acquiring rest 201Tl SPECT, 20 g of glucose were intravenously injected into the fasting subjects. Thallium perfusion defects were compared to those of conventional rest- redistribution SPECT images obtained within a 2-wk interval. SPECT images were divided into 21 segments, and a defect score in 17 segments was calculated as a sum of the semiquantitative defect scores (0 = normal; I = mildly decreased uptake; 2 = severely decreased uptake; 3 = absence of uptake). Results: Thallium-201 uptake in isolated hearts showed a significant increase of 26% after insulin loading. Eleven (24%) of 45 segments showing perfusion defects on the conventional rest SPECT images demonstrated 201Tl uptake on glucose-loading SPECT imaging. Defect scores decreased significantly on the glucose-loading SPECT images (9.9 ± 2.2 in early images; mean ± s.e.) compared with the conventional rest-redistribution SPECT images (12.6 ± 6.9 in delayed images, p <0.05). Conclusion: Glucose- loading SPECT represents a superior method for assessing myocardial viability using 201Tl.
KW - glucose loading
KW - hibernating myocardium
KW - myocardial SPECT
KW - thallium-201
UR - http://www.scopus.com/inward/record.url?scp=0030898905&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030898905&partnerID=8YFLogxK
M3 - Article
C2 - 9098204
AN - SCOPUS:0030898905
VL - 38
SP - 573
EP - 577
JO - Journal of Nuclear Medicine
JF - Journal of Nuclear Medicine
SN - 0161-5505
IS - 4
ER -