Glucose-loading thallium-201 myocardial SPECT

Hiroshi Chiba, Hideo Kusuoka, Joichi Ohno, Tsunehiko Nishimura

Research output: Contribution to journalArticle

Abstract

This study was designed to evaluate the feasibility of assessing myocardial viability using glucose loading followed by 201Tl SPECT. Methods: First, the effect of insulin on the kinetics of 201Tl uptake was evaluated in isolated perfused rat hearts. Second, glucose-loading 201Tl myocardial SPECT was performed in 13 nondiabetic patients with histories of anterior myocardial infarction. Thirty minutes before acquiring rest 201Tl SPECT, 20 g of glucose were intravenously injected into the fasting subjects. Thallium perfusion defects were compared to those of conventional rest- redistribution SPECT images obtained within a 2-wk interval. SPECT images were divided into 21 segments, and a defect score in 17 segments was calculated as a sum of the semiquantitative defect scores (0 = normal; I = mildly decreased uptake; 2 = severely decreased uptake; 3 = absence of uptake). Results: Thallium-201 uptake in isolated hearts showed a significant increase of 26% after insulin loading. Eleven (24%) of 45 segments showing perfusion defects on the conventional rest SPECT images demonstrated 201Tl uptake on glucose-loading SPECT imaging. Defect scores decreased significantly on the glucose-loading SPECT images (9.9 ± 2.2 in early images; mean ± s.e.) compared with the conventional rest-redistribution SPECT images (12.6 ± 6.9 in delayed images, p <0.05). Conclusion: Glucose- loading SPECT represents a superior method for assessing myocardial viability using 201Tl.

Original languageEnglish (US)
Pages (from-to)573-577
Number of pages5
JournalJournal of Nuclear Medicine
Volume38
Issue number4
StatePublished - 1997
Externally publishedYes

Fingerprint

Thallium
Single-Photon Emission-Computed Tomography
Glucose
Perfusion
Insulin
Fasting
Myocardial Infarction

Keywords

  • glucose loading
  • hibernating myocardium
  • myocardial SPECT
  • thallium-201

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Chiba, H., Kusuoka, H., Ohno, J., & Nishimura, T. (1997). Glucose-loading thallium-201 myocardial SPECT. Journal of Nuclear Medicine, 38(4), 573-577.

Glucose-loading thallium-201 myocardial SPECT. / Chiba, Hiroshi; Kusuoka, Hideo; Ohno, Joichi; Nishimura, Tsunehiko.

In: Journal of Nuclear Medicine, Vol. 38, No. 4, 1997, p. 573-577.

Research output: Contribution to journalArticle

Chiba, H, Kusuoka, H, Ohno, J & Nishimura, T 1997, 'Glucose-loading thallium-201 myocardial SPECT', Journal of Nuclear Medicine, vol. 38, no. 4, pp. 573-577.
Chiba H, Kusuoka H, Ohno J, Nishimura T. Glucose-loading thallium-201 myocardial SPECT. Journal of Nuclear Medicine. 1997;38(4):573-577.
Chiba, Hiroshi ; Kusuoka, Hideo ; Ohno, Joichi ; Nishimura, Tsunehiko. / Glucose-loading thallium-201 myocardial SPECT. In: Journal of Nuclear Medicine. 1997 ; Vol. 38, No. 4. pp. 573-577.
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