Glucose and insulin measurements from the oral glucose tolerance test and mortality prediction

E. Jeffrey Metter, B. Gwen Windham, Marcello Maggio, Eleanor Marie Simonsick, Shari M. Ling, Josephine M. Egan, Luigi Ferrucci

Research output: Contribution to journalArticle

Abstract

OBJECTIVE - To verify what information from oral glucose tolerance tests (OGTTs) independently predicts mortality. RESEARCH DESIGN AND METHODS - A total of 1,401 initially nondiabetic participants from the Baltimore Longitudinal Study of Aging aged 17-95 years underwent one or more OGTTs (median 2, range 1-8), with insulin and glucose measurements taken every 20 min over the course of 2 h included in this study. Proportional hazards using the longitudinally collected data and Bayesian model averaging were used to examine the association of OGTT measurements individually and grouped with mortality, adjusting for covariates. RESULTS - Participants were followed for a median 20.3 years (range 0.5-40). The first- hour OGTT glucose and insulin levels increased only modestly with age, whereas levels during the second hour increased 4% per decade. Individually, 100- and 120-min glucose measures and fasting and 100-min insulin levels were all independent predictors of mortality. When all measures were considered together, only higher 120-min glucose was a significant independent risk factor for mortality. CONCLUSION - The steeper rise with age of the OGTT 2-h glucose values and the prognostic primacy of the 120-min glucose value for mortality is consistent with previous reports and suggests the value of using the OGTT in clinical practice.

Original languageEnglish (US)
Pages (from-to)1026-1030
Number of pages5
JournalDiabetes Care
Volume31
Issue number5
DOIs
StatePublished - May 2008
Externally publishedYes

Fingerprint

Glucose Tolerance Test
Insulin
Glucose
Mortality
Baltimore
Longitudinal Studies
Fasting
Research Design

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing

Cite this

Metter, E. J., Windham, B. G., Maggio, M., Simonsick, E. M., Ling, S. M., Egan, J. M., & Ferrucci, L. (2008). Glucose and insulin measurements from the oral glucose tolerance test and mortality prediction. Diabetes Care, 31(5), 1026-1030. https://doi.org/10.2337/dc07-2102

Glucose and insulin measurements from the oral glucose tolerance test and mortality prediction. / Metter, E. Jeffrey; Windham, B. Gwen; Maggio, Marcello; Simonsick, Eleanor Marie; Ling, Shari M.; Egan, Josephine M.; Ferrucci, Luigi.

In: Diabetes Care, Vol. 31, No. 5, 05.2008, p. 1026-1030.

Research output: Contribution to journalArticle

Metter, EJ, Windham, BG, Maggio, M, Simonsick, EM, Ling, SM, Egan, JM & Ferrucci, L 2008, 'Glucose and insulin measurements from the oral glucose tolerance test and mortality prediction', Diabetes Care, vol. 31, no. 5, pp. 1026-1030. https://doi.org/10.2337/dc07-2102
Metter, E. Jeffrey ; Windham, B. Gwen ; Maggio, Marcello ; Simonsick, Eleanor Marie ; Ling, Shari M. ; Egan, Josephine M. ; Ferrucci, Luigi. / Glucose and insulin measurements from the oral glucose tolerance test and mortality prediction. In: Diabetes Care. 2008 ; Vol. 31, No. 5. pp. 1026-1030.
@article{6f21ece5e3df4b1bb2e389249938ca9f,
title = "Glucose and insulin measurements from the oral glucose tolerance test and mortality prediction",
abstract = "OBJECTIVE - To verify what information from oral glucose tolerance tests (OGTTs) independently predicts mortality. RESEARCH DESIGN AND METHODS - A total of 1,401 initially nondiabetic participants from the Baltimore Longitudinal Study of Aging aged 17-95 years underwent one or more OGTTs (median 2, range 1-8), with insulin and glucose measurements taken every 20 min over the course of 2 h included in this study. Proportional hazards using the longitudinally collected data and Bayesian model averaging were used to examine the association of OGTT measurements individually and grouped with mortality, adjusting for covariates. RESULTS - Participants were followed for a median 20.3 years (range 0.5-40). The first- hour OGTT glucose and insulin levels increased only modestly with age, whereas levels during the second hour increased 4{\%} per decade. Individually, 100- and 120-min glucose measures and fasting and 100-min insulin levels were all independent predictors of mortality. When all measures were considered together, only higher 120-min glucose was a significant independent risk factor for mortality. CONCLUSION - The steeper rise with age of the OGTT 2-h glucose values and the prognostic primacy of the 120-min glucose value for mortality is consistent with previous reports and suggests the value of using the OGTT in clinical practice.",
author = "Metter, {E. Jeffrey} and Windham, {B. Gwen} and Marcello Maggio and Simonsick, {Eleanor Marie} and Ling, {Shari M.} and Egan, {Josephine M.} and Luigi Ferrucci",
year = "2008",
month = "5",
doi = "10.2337/dc07-2102",
language = "English (US)",
volume = "31",
pages = "1026--1030",
journal = "Diabetes Care",
issn = "1935-5548",
publisher = "American Diabetes Association Inc.",
number = "5",

}

TY - JOUR

T1 - Glucose and insulin measurements from the oral glucose tolerance test and mortality prediction

AU - Metter, E. Jeffrey

AU - Windham, B. Gwen

AU - Maggio, Marcello

AU - Simonsick, Eleanor Marie

AU - Ling, Shari M.

AU - Egan, Josephine M.

AU - Ferrucci, Luigi

PY - 2008/5

Y1 - 2008/5

N2 - OBJECTIVE - To verify what information from oral glucose tolerance tests (OGTTs) independently predicts mortality. RESEARCH DESIGN AND METHODS - A total of 1,401 initially nondiabetic participants from the Baltimore Longitudinal Study of Aging aged 17-95 years underwent one or more OGTTs (median 2, range 1-8), with insulin and glucose measurements taken every 20 min over the course of 2 h included in this study. Proportional hazards using the longitudinally collected data and Bayesian model averaging were used to examine the association of OGTT measurements individually and grouped with mortality, adjusting for covariates. RESULTS - Participants were followed for a median 20.3 years (range 0.5-40). The first- hour OGTT glucose and insulin levels increased only modestly with age, whereas levels during the second hour increased 4% per decade. Individually, 100- and 120-min glucose measures and fasting and 100-min insulin levels were all independent predictors of mortality. When all measures were considered together, only higher 120-min glucose was a significant independent risk factor for mortality. CONCLUSION - The steeper rise with age of the OGTT 2-h glucose values and the prognostic primacy of the 120-min glucose value for mortality is consistent with previous reports and suggests the value of using the OGTT in clinical practice.

AB - OBJECTIVE - To verify what information from oral glucose tolerance tests (OGTTs) independently predicts mortality. RESEARCH DESIGN AND METHODS - A total of 1,401 initially nondiabetic participants from the Baltimore Longitudinal Study of Aging aged 17-95 years underwent one or more OGTTs (median 2, range 1-8), with insulin and glucose measurements taken every 20 min over the course of 2 h included in this study. Proportional hazards using the longitudinally collected data and Bayesian model averaging were used to examine the association of OGTT measurements individually and grouped with mortality, adjusting for covariates. RESULTS - Participants were followed for a median 20.3 years (range 0.5-40). The first- hour OGTT glucose and insulin levels increased only modestly with age, whereas levels during the second hour increased 4% per decade. Individually, 100- and 120-min glucose measures and fasting and 100-min insulin levels were all independent predictors of mortality. When all measures were considered together, only higher 120-min glucose was a significant independent risk factor for mortality. CONCLUSION - The steeper rise with age of the OGTT 2-h glucose values and the prognostic primacy of the 120-min glucose value for mortality is consistent with previous reports and suggests the value of using the OGTT in clinical practice.

UR - http://www.scopus.com/inward/record.url?scp=48649105817&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=48649105817&partnerID=8YFLogxK

U2 - 10.2337/dc07-2102

DO - 10.2337/dc07-2102

M3 - Article

VL - 31

SP - 1026

EP - 1030

JO - Diabetes Care

JF - Diabetes Care

SN - 1935-5548

IS - 5

ER -