Glucose-6-phosphate dehydrogenase (G6PD) mutations in Myanmar: G6PD Mahidol (487G>A) is the most common variant in the Myanmar population

Hiroyuki Matsuoka; Jichun Wang; Makoto Hirai; Meiji Arai; Shigeto Yoshida; Tamaki Kobayashi; Amadu Jalloh; Khin Lin; Fumihiko Kawamoto

doi:10.1007/s10038-004-0187-7

Glucose-6-phosphate dehydrogenase (G6PD) mutations in Myanmar: G6PD Mahidol (487G>A) is the most common variant in the Myanmar population

Hiroyuki Matsuoka, Jichun Wang, Makoto Hirai, Meiji Arai, Shigeto Yoshida, Tamaki Kobayashi, Amadu Jalloh, Khin Lin, Fumihiko Kawamoto

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

We conducted a survey of malaria diagnoses and treatments in remote areas of Myanmar. Blood specimens from more than 1,000 people were collected by the finger-prick method, and 121 (11%) of these people were found to be glucose-6-phosphate dehydrogenase (G6PD) deficient. Of these 121, 50 consented to analysis of the G6PD genome. We read the G6PD sequences of these subjects and found 45 cases of G6PD Mahidol (487G>A), two of G6PD Coimbra (592C>T), two of G6PD Union (1360C>T), and one of G6PD Canton (1376G>T). Taken together with data from our previous report, 91.3% (73/80) of G6PD variants were G6PD Mahidol. This finding suggests that the Myanmar population is derived from homogeneous ancestries and are different from Thai, Malaysian, and Indonesian populations.

Original language	English (US)
Pages (from-to)	544-547
Number of pages	4
Journal	Journal of Human Genetics
Volume	49
Issue number	10
DOIs	https://doi.org/10.1007/s10038-004-0187-7
State	Published - Oct 2004
Externally published	Yes

Keywords

Glucose-6-phosphate dehydrogenase deficiency
Mahidol
Malaria
Myanmar
Primaquine

ASJC Scopus subject areas

Genetics
Genetics(clinical)

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title = "Glucose-6-phosphate dehydrogenase (G6PD) mutations in Myanmar: G6PD Mahidol (487G>A) is the most common variant in the Myanmar population",

abstract = "We conducted a survey of malaria diagnoses and treatments in remote areas of Myanmar. Blood specimens from more than 1,000 people were collected by the finger-prick method, and 121 (11%) of these people were found to be glucose-6-phosphate dehydrogenase (G6PD) deficient. Of these 121, 50 consented to analysis of the G6PD genome. We read the G6PD sequences of these subjects and found 45 cases of G6PD Mahidol (487G>A), two of G6PD Coimbra (592C>T), two of G6PD Union (1360C>T), and one of G6PD Canton (1376G>T). Taken together with data from our previous report, 91.3% (73/80) of G6PD variants were G6PD Mahidol. This finding suggests that the Myanmar population is derived from homogeneous ancestries and are different from Thai, Malaysian, and Indonesian populations.",

keywords = "Glucose-6-phosphate dehydrogenase deficiency, Mahidol, Malaria, Myanmar, Primaquine",

author = "Hiroyuki Matsuoka and Jichun Wang and Makoto Hirai and Meiji Arai and Shigeto Yoshida and Tamaki Kobayashi and Amadu Jalloh and Khin Lin and Fumihiko Kawamoto",

year = "2004",

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doi = "10.1007/s10038-004-0187-7",

language = "English (US)",

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T1 - Glucose-6-phosphate dehydrogenase (G6PD) mutations in Myanmar

T2 - G6PD Mahidol (487G>A) is the most common variant in the Myanmar population

AU - Matsuoka, Hiroyuki

AU - Wang, Jichun

AU - Hirai, Makoto

AU - Arai, Meiji

AU - Yoshida, Shigeto

AU - Kobayashi, Tamaki

AU - Jalloh, Amadu

AU - Lin, Khin

AU - Kawamoto, Fumihiko

PY - 2004/10

Y1 - 2004/10

N2 - We conducted a survey of malaria diagnoses and treatments in remote areas of Myanmar. Blood specimens from more than 1,000 people were collected by the finger-prick method, and 121 (11%) of these people were found to be glucose-6-phosphate dehydrogenase (G6PD) deficient. Of these 121, 50 consented to analysis of the G6PD genome. We read the G6PD sequences of these subjects and found 45 cases of G6PD Mahidol (487G>A), two of G6PD Coimbra (592C>T), two of G6PD Union (1360C>T), and one of G6PD Canton (1376G>T). Taken together with data from our previous report, 91.3% (73/80) of G6PD variants were G6PD Mahidol. This finding suggests that the Myanmar population is derived from homogeneous ancestries and are different from Thai, Malaysian, and Indonesian populations.

AB - We conducted a survey of malaria diagnoses and treatments in remote areas of Myanmar. Blood specimens from more than 1,000 people were collected by the finger-prick method, and 121 (11%) of these people were found to be glucose-6-phosphate dehydrogenase (G6PD) deficient. Of these 121, 50 consented to analysis of the G6PD genome. We read the G6PD sequences of these subjects and found 45 cases of G6PD Mahidol (487G>A), two of G6PD Coimbra (592C>T), two of G6PD Union (1360C>T), and one of G6PD Canton (1376G>T). Taken together with data from our previous report, 91.3% (73/80) of G6PD variants were G6PD Mahidol. This finding suggests that the Myanmar population is derived from homogeneous ancestries and are different from Thai, Malaysian, and Indonesian populations.

KW - Glucose-6-phosphate dehydrogenase deficiency

KW - Mahidol

KW - Malaria

KW - Myanmar

KW - Primaquine

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Glucose-6-phosphate dehydrogenase (G6PD) mutations in Myanmar: G6PD Mahidol (487G>A) is the most common variant in the Myanmar population

Abstract

Keywords

ASJC Scopus subject areas

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