Glucocorticoids and the rhesus fetal lung

John W C Johnson, Wayne A Mitzner, William T. London, Amos E. Palmer, Rachel Scott, Kevin Kearney

Research output: Contribution to journalArticle

Abstract

The effects of glucocorticoids on primate fetal lung function have not been clearly delineated. In this prospective study of preterm rhesus fetuses exposed in utero to betamethasone for 72 hours, the most significant alteration was a striking increase in maximum lung volumes. Functionally less significant increases in residual lung volumes were also noted. The lungs of the treated fetuses did not exhibit lower extract surface tensions or increased phospholipid concentrations. These findings suggest that the major effect of betamethasone is on lung connective tissue elements, with minimal effects on alveolar surfactant. Additional evidence of the multisystemic effects of glucocorticoids was obtained in that significant differences in fetal, adrenal, hepatic, and placental weights also were observed.

Original languageEnglish (US)
Pages (from-to)905-916
Number of pages12
JournalAmerican Journal of Obstetrics and Gynecology
Volume130
Issue number8
StatePublished - Apr 15 1978

Fingerprint

Glucocorticoids
Lung
Betamethasone
Fetus
Residual Volume
Surface Tension
Surface-Active Agents
Connective Tissue
Primates
Phospholipids
Prospective Studies
Weights and Measures
Liver

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Johnson, J. W. C., Mitzner, W. A., London, W. T., Palmer, A. E., Scott, R., & Kearney, K. (1978). Glucocorticoids and the rhesus fetal lung. American Journal of Obstetrics and Gynecology, 130(8), 905-916.

Glucocorticoids and the rhesus fetal lung. / Johnson, John W C; Mitzner, Wayne A; London, William T.; Palmer, Amos E.; Scott, Rachel; Kearney, Kevin.

In: American Journal of Obstetrics and Gynecology, Vol. 130, No. 8, 15.04.1978, p. 905-916.

Research output: Contribution to journalArticle

Johnson, JWC, Mitzner, WA, London, WT, Palmer, AE, Scott, R & Kearney, K 1978, 'Glucocorticoids and the rhesus fetal lung', American Journal of Obstetrics and Gynecology, vol. 130, no. 8, pp. 905-916.
Johnson JWC, Mitzner WA, London WT, Palmer AE, Scott R, Kearney K. Glucocorticoids and the rhesus fetal lung. American Journal of Obstetrics and Gynecology. 1978 Apr 15;130(8):905-916.
Johnson, John W C ; Mitzner, Wayne A ; London, William T. ; Palmer, Amos E. ; Scott, Rachel ; Kearney, Kevin. / Glucocorticoids and the rhesus fetal lung. In: American Journal of Obstetrics and Gynecology. 1978 ; Vol. 130, No. 8. pp. 905-916.
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