Glucocorticoid treatment of girls with congenital adrenal hyperplasia: Effects on height, sexual maturation, and fertility

Georgeanna Jones Klingensmith, Silvia Cristina Garcia, Howard W. Jones, Claude J. Migeon, Robert M. Blizzard

Research output: Contribution to journalArticle

Abstract

Ninety-eight females with congenital adrenal hyperplasia due to a defect in either the 21-hydroxylase or the 11β-hydroxylase enzyme were evaluated to determine the effects of glucocorticoid treatment on growth, pubertal development, and fertility. When treatment was begun prior to one year of age, mean final height was 157.4±7.3 cm, well within the normal adult female range, and significantly (p7.0 mg/24 hours. The increased production of adrenal androgens was the result of poor compliance or an insufficient prescribed dose of glucocorticoids. The fertility rate in patients first treated between six and 20 years of age was 64%. The excretion of urinary 17 KS at the time of pregnancy was 2.5 to 5.3 mg/24 hours. All of the patients who delivered term infants required delivery by cesarean section because of cephalopelvic disproportion. The major problems encountered in the management of adolescent patients were patient noncompliance and physician failure to increase the glucocorticoid dose as the patient's body size increased.

Original languageEnglish (US)
Pages (from-to)996-1004
Number of pages9
JournalJournal of Pediatrics
Volume90
Issue number6
DOIs
StatePublished - 1977

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Sexual Maturation
Congenital Adrenal Hyperplasia
Glucocorticoids
Fertility
Cephalopelvic Disproportion
Steroid 21-Hydroxylase
Birth Rate
Body Size
Therapeutics
Patient Compliance
Mixed Function Oxygenases
Growth and Development
Cesarean Section
Androgens
Physicians
Pregnancy
Enzymes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Glucocorticoid treatment of girls with congenital adrenal hyperplasia : Effects on height, sexual maturation, and fertility. / Klingensmith, Georgeanna Jones; Garcia, Silvia Cristina; Jones, Howard W.; Migeon, Claude J.; Blizzard, Robert M.

In: Journal of Pediatrics, Vol. 90, No. 6, 1977, p. 996-1004.

Research output: Contribution to journalArticle

Klingensmith, Georgeanna Jones ; Garcia, Silvia Cristina ; Jones, Howard W. ; Migeon, Claude J. ; Blizzard, Robert M. / Glucocorticoid treatment of girls with congenital adrenal hyperplasia : Effects on height, sexual maturation, and fertility. In: Journal of Pediatrics. 1977 ; Vol. 90, No. 6. pp. 996-1004.
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