Abstract
Purpose: To examine the detection sensitivity for the rapidly exchanging hydroxyl protons of D-glucose using the recently developed on-resonance variable delay multi-pulse (onVDMP) chemical exchange saturation transfer (CEST) technique. Methods: The onVDMP method was applied for the detection of water signal changes upon venous D-glucose infusion in mice with 9L glioma xenografts. The effect size of onVDMP MRI during infusion was compared with that of conventional continuous wave (CW) CEST MRI. Results: Both methods highlighted the tumor and the blood vessels on D-glucose infusion. In interleaved studies, the mean signal changes detected by onVDMP were found to be 1.8 times higher than those by CW-CEST, attributed to its high labeling efficiency for fast exchanging protons and the labeling of the OH protons over a larger frequency range. Conclusions: The onVDMP method is a more sensitive technique for the detection of exogenous CEST agents with fast-exchanging protons compared to CW-CEST MRI.
| Original language | English (US) |
|---|---|
| Journal | Magnetic Resonance in Medicine |
| DOIs | |
| State | Accepted/In press - Jan 1 2018 |
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Keywords
- Chemical exchange
- Glioma
- GlucoCEST
- On-resonance variable delay multiple pulse (onVDMP)
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
Cite this
GlucoCEST imaging with on-resonance variable delay multiple pulse (onVDMP) MRI. / Xu, Xiang; Xu, Jiadi; Chan, Kannie W.Y.; Liu, Jing; Liu, Huanling; Li, Yuguo; Chen, Lin; Liu, Guanshu; Van Zijl, Peter C.
In: Magnetic Resonance in Medicine, 01.01.2018.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - GlucoCEST imaging with on-resonance variable delay multiple pulse (onVDMP) MRI
AU - Xu, Xiang
AU - Xu, Jiadi
AU - Chan, Kannie W.Y.
AU - Liu, Jing
AU - Liu, Huanling
AU - Li, Yuguo
AU - Chen, Lin
AU - Liu, Guanshu
AU - Van Zijl, Peter C
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Purpose: To examine the detection sensitivity for the rapidly exchanging hydroxyl protons of D-glucose using the recently developed on-resonance variable delay multi-pulse (onVDMP) chemical exchange saturation transfer (CEST) technique. Methods: The onVDMP method was applied for the detection of water signal changes upon venous D-glucose infusion in mice with 9L glioma xenografts. The effect size of onVDMP MRI during infusion was compared with that of conventional continuous wave (CW) CEST MRI. Results: Both methods highlighted the tumor and the blood vessels on D-glucose infusion. In interleaved studies, the mean signal changes detected by onVDMP were found to be 1.8 times higher than those by CW-CEST, attributed to its high labeling efficiency for fast exchanging protons and the labeling of the OH protons over a larger frequency range. Conclusions: The onVDMP method is a more sensitive technique for the detection of exogenous CEST agents with fast-exchanging protons compared to CW-CEST MRI.
AB - Purpose: To examine the detection sensitivity for the rapidly exchanging hydroxyl protons of D-glucose using the recently developed on-resonance variable delay multi-pulse (onVDMP) chemical exchange saturation transfer (CEST) technique. Methods: The onVDMP method was applied for the detection of water signal changes upon venous D-glucose infusion in mice with 9L glioma xenografts. The effect size of onVDMP MRI during infusion was compared with that of conventional continuous wave (CW) CEST MRI. Results: Both methods highlighted the tumor and the blood vessels on D-glucose infusion. In interleaved studies, the mean signal changes detected by onVDMP were found to be 1.8 times higher than those by CW-CEST, attributed to its high labeling efficiency for fast exchanging protons and the labeling of the OH protons over a larger frequency range. Conclusions: The onVDMP method is a more sensitive technique for the detection of exogenous CEST agents with fast-exchanging protons compared to CW-CEST MRI.
KW - Chemical exchange
KW - Glioma
KW - GlucoCEST
KW - On-resonance variable delay multiple pulse (onVDMP)
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U2 - 10.1002/mrm.27364
DO - 10.1002/mrm.27364
M3 - Article
C2 - 30058240
AN - SCOPUS:85050860630
JO - Magnetic Resonance in Medicine
JF - Magnetic Resonance in Medicine
SN - 0740-3194
ER -