GlucoCEST imaging with on-resonance variable delay multiple pulse (onVDMP) MRI

Xiang Xu, Jiadi Xu, Kannie W.Y. Chan, Jing Liu, Huanling Liu, Yuguo Li, Lin Chen, Guanshu Liu, Peter C Van Zijl

Research output: Contribution to journalArticle

Abstract

Purpose: To examine the detection sensitivity for the rapidly exchanging hydroxyl protons of D-glucose using the recently developed on-resonance variable delay multi-pulse (onVDMP) chemical exchange saturation transfer (CEST) technique. Methods: The onVDMP method was applied for the detection of water signal changes upon venous D-glucose infusion in mice with 9L glioma xenografts. The effect size of onVDMP MRI during infusion was compared with that of conventional continuous wave (CW) CEST MRI. Results: Both methods highlighted the tumor and the blood vessels on D-glucose infusion. In interleaved studies, the mean signal changes detected by onVDMP were found to be 1.8 times higher than those by CW-CEST, attributed to its high labeling efficiency for fast exchanging protons and the labeling of the OH protons over a larger frequency range. Conclusions: The onVDMP method is a more sensitive technique for the detection of exogenous CEST agents with fast-exchanging protons compared to CW-CEST MRI.

Original languageEnglish (US)
JournalMagnetic Resonance in Medicine
DOIs
StateAccepted/In press - Jan 1 2018

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Protons
Glucose
Vascular Tissue Neoplasms
Heterografts
Glioma
Hydroxyl Radical
Water

Keywords

  • Chemical exchange
  • Glioma
  • GlucoCEST
  • On-resonance variable delay multiple pulse (onVDMP)

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

GlucoCEST imaging with on-resonance variable delay multiple pulse (onVDMP) MRI. / Xu, Xiang; Xu, Jiadi; Chan, Kannie W.Y.; Liu, Jing; Liu, Huanling; Li, Yuguo; Chen, Lin; Liu, Guanshu; Van Zijl, Peter C.

In: Magnetic Resonance in Medicine, 01.01.2018.

Research output: Contribution to journalArticle

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AU - Xu, Jiadi

AU - Chan, Kannie W.Y.

AU - Liu, Jing

AU - Liu, Huanling

AU - Li, Yuguo

AU - Chen, Lin

AU - Liu, Guanshu

AU - Van Zijl, Peter C

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N2 - Purpose: To examine the detection sensitivity for the rapidly exchanging hydroxyl protons of D-glucose using the recently developed on-resonance variable delay multi-pulse (onVDMP) chemical exchange saturation transfer (CEST) technique. Methods: The onVDMP method was applied for the detection of water signal changes upon venous D-glucose infusion in mice with 9L glioma xenografts. The effect size of onVDMP MRI during infusion was compared with that of conventional continuous wave (CW) CEST MRI. Results: Both methods highlighted the tumor and the blood vessels on D-glucose infusion. In interleaved studies, the mean signal changes detected by onVDMP were found to be 1.8 times higher than those by CW-CEST, attributed to its high labeling efficiency for fast exchanging protons and the labeling of the OH protons over a larger frequency range. Conclusions: The onVDMP method is a more sensitive technique for the detection of exogenous CEST agents with fast-exchanging protons compared to CW-CEST MRI.

AB - Purpose: To examine the detection sensitivity for the rapidly exchanging hydroxyl protons of D-glucose using the recently developed on-resonance variable delay multi-pulse (onVDMP) chemical exchange saturation transfer (CEST) technique. Methods: The onVDMP method was applied for the detection of water signal changes upon venous D-glucose infusion in mice with 9L glioma xenografts. The effect size of onVDMP MRI during infusion was compared with that of conventional continuous wave (CW) CEST MRI. Results: Both methods highlighted the tumor and the blood vessels on D-glucose infusion. In interleaved studies, the mean signal changes detected by onVDMP were found to be 1.8 times higher than those by CW-CEST, attributed to its high labeling efficiency for fast exchanging protons and the labeling of the OH protons over a larger frequency range. Conclusions: The onVDMP method is a more sensitive technique for the detection of exogenous CEST agents with fast-exchanging protons compared to CW-CEST MRI.

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KW - GlucoCEST

KW - On-resonance variable delay multiple pulse (onVDMP)

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