GlucoCEST imaging with on-resonance variable delay multiple pulse (onVDMP) MRI

Xiang Xu; Jiadi Xu; Kannie W.Y. Chan; Jing Liu; Huanling Liu; Yuguo Li; Lin Chen; Guanshu Liu; Peter C.M. van Zijl

doi:10.1002/mrm.27364

GlucoCEST imaging with on-resonance variable delay multiple pulse (onVDMP) MRI

Xiang Xu, Jiadi Xu, Kannie W.Y. Chan, Jing Liu, Huanling Liu, Yuguo Li, Lin Chen, Guanshu Liu, Peter C.M. van Zijl

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Purpose: To examine the detection sensitivity for the rapidly exchanging hydroxyl protons of D-glucose using the recently developed on-resonance variable delay multi-pulse (onVDMP) chemical exchange saturation transfer (CEST) technique. Methods: The onVDMP method was applied for the detection of water signal changes upon venous D-glucose infusion in mice with 9L glioma xenografts. The effect size of onVDMP MRI during infusion was compared with that of conventional continuous wave (CW) CEST MRI. Results: Both methods highlighted the tumor and the blood vessels on D-glucose infusion. In interleaved studies, the mean signal changes detected by onVDMP were found to be 1.8 times higher than those by CW-CEST, attributed to its high labeling efficiency for fast exchanging protons and the labeling of the OH protons over a larger frequency range. Conclusions: The onVDMP method is a more sensitive technique for the detection of exogenous CEST agents with fast-exchanging protons compared to CW-CEST MRI.

Original language	English (US)
Pages (from-to)	47-56
Number of pages	10
Journal	Magnetic resonance in medicine
Volume	81
Issue number	1
DOIs	https://doi.org/10.1002/mrm.27364
State	Published - Jan 2019

Keywords

Chemical exchange
glioma
glucoCEST
on-resonance variable delay multiple pulse (onVDMP)

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1002/mrm.27364

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title = "GlucoCEST imaging with on-resonance variable delay multiple pulse (onVDMP) MRI",

abstract = "Purpose: To examine the detection sensitivity for the rapidly exchanging hydroxyl protons of D-glucose using the recently developed on-resonance variable delay multi-pulse (onVDMP) chemical exchange saturation transfer (CEST) technique. Methods: The onVDMP method was applied for the detection of water signal changes upon venous D-glucose infusion in mice with 9L glioma xenografts. The effect size of onVDMP MRI during infusion was compared with that of conventional continuous wave (CW) CEST MRI. Results: Both methods highlighted the tumor and the blood vessels on D-glucose infusion. In interleaved studies, the mean signal changes detected by onVDMP were found to be 1.8 times higher than those by CW-CEST, attributed to its high labeling efficiency for fast exchanging protons and the labeling of the OH protons over a larger frequency range. Conclusions: The onVDMP method is a more sensitive technique for the detection of exogenous CEST agents with fast-exchanging protons compared to CW-CEST MRI.",

keywords = "Chemical exchange, glioma, glucoCEST, on-resonance variable delay multiple pulse (onVDMP)",

author = "Xiang Xu and Jiadi Xu and Chan, {Kannie W.Y.} and Jing Liu and Huanling Liu and Yuguo Li and Lin Chen and Guanshu Liu and {van Zijl}, {Peter C.M.}",

note = "Funding Information: This work was supported by National Institutes of Health, Grant/Award Numbers: NIH R01EB019934, P50CA103175, R01EB015032, R21EB018934 and K99EB026312. Publisher Copyright: {\textcopyright} 2018 International Society for Magnetic Resonance in Medicine",

year = "2019",

month = jan,

doi = "10.1002/mrm.27364",

language = "English (US)",

volume = "81",

pages = "47--56",

journal = "Magnetic Resonance in Medicine",

issn = "0740-3194",

publisher = "John Wiley and Sons Inc.",

number = "1",

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TY - JOUR

T1 - GlucoCEST imaging with on-resonance variable delay multiple pulse (onVDMP) MRI

AU - Xu, Xiang

AU - Xu, Jiadi

AU - Chan, Kannie W.Y.

AU - Liu, Jing

AU - Liu, Huanling

AU - Li, Yuguo

AU - Chen, Lin

AU - Liu, Guanshu

AU - van Zijl, Peter C.M.

N1 - Funding Information: This work was supported by National Institutes of Health, Grant/Award Numbers: NIH R01EB019934, P50CA103175, R01EB015032, R21EB018934 and K99EB026312. Publisher Copyright: © 2018 International Society for Magnetic Resonance in Medicine

PY - 2019/1

Y1 - 2019/1

N2 - Purpose: To examine the detection sensitivity for the rapidly exchanging hydroxyl protons of D-glucose using the recently developed on-resonance variable delay multi-pulse (onVDMP) chemical exchange saturation transfer (CEST) technique. Methods: The onVDMP method was applied for the detection of water signal changes upon venous D-glucose infusion in mice with 9L glioma xenografts. The effect size of onVDMP MRI during infusion was compared with that of conventional continuous wave (CW) CEST MRI. Results: Both methods highlighted the tumor and the blood vessels on D-glucose infusion. In interleaved studies, the mean signal changes detected by onVDMP were found to be 1.8 times higher than those by CW-CEST, attributed to its high labeling efficiency for fast exchanging protons and the labeling of the OH protons over a larger frequency range. Conclusions: The onVDMP method is a more sensitive technique for the detection of exogenous CEST agents with fast-exchanging protons compared to CW-CEST MRI.

AB - Purpose: To examine the detection sensitivity for the rapidly exchanging hydroxyl protons of D-glucose using the recently developed on-resonance variable delay multi-pulse (onVDMP) chemical exchange saturation transfer (CEST) technique. Methods: The onVDMP method was applied for the detection of water signal changes upon venous D-glucose infusion in mice with 9L glioma xenografts. The effect size of onVDMP MRI during infusion was compared with that of conventional continuous wave (CW) CEST MRI. Results: Both methods highlighted the tumor and the blood vessels on D-glucose infusion. In interleaved studies, the mean signal changes detected by onVDMP were found to be 1.8 times higher than those by CW-CEST, attributed to its high labeling efficiency for fast exchanging protons and the labeling of the OH protons over a larger frequency range. Conclusions: The onVDMP method is a more sensitive technique for the detection of exogenous CEST agents with fast-exchanging protons compared to CW-CEST MRI.

KW - Chemical exchange

KW - glioma

KW - glucoCEST

KW - on-resonance variable delay multiple pulse (onVDMP)

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GlucoCEST imaging with on-resonance variable delay multiple pulse (onVDMP) MRI

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