GlucoCEST imaging with on-resonance variable delay multiple pulse (onVDMP) MRI

Xiang Xu, Jiadi Xu, Kannie W.Y. Chan, Jing Liu, Huanling Liu, Yuguo Li, Lin Chen, Guanshu Liu, Peter C.M. van Zijl

Research output: Contribution to journalArticle

Abstract

Purpose: To examine the detection sensitivity for the rapidly exchanging hydroxyl protons of D-glucose using the recently developed on-resonance variable delay multi-pulse (onVDMP) chemical exchange saturation transfer (CEST) technique. Methods: The onVDMP method was applied for the detection of water signal changes upon venous D-glucose infusion in mice with 9L glioma xenografts. The effect size of onVDMP MRI during infusion was compared with that of conventional continuous wave (CW) CEST MRI. Results: Both methods highlighted the tumor and the blood vessels on D-glucose infusion. In interleaved studies, the mean signal changes detected by onVDMP were found to be 1.8 times higher than those by CW-CEST, attributed to its high labeling efficiency for fast exchanging protons and the labeling of the OH protons over a larger frequency range. Conclusions: The onVDMP method is a more sensitive technique for the detection of exogenous CEST agents with fast-exchanging protons compared to CW-CEST MRI.

Original languageEnglish (US)
Pages (from-to)47-56
Number of pages10
JournalMagnetic resonance in medicine
Volume81
Issue number1
DOIs
StatePublished - Jan 2019

Keywords

  • Chemical exchange
  • glioma
  • glucoCEST
  • on-resonance variable delay multiple pulse (onVDMP)

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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