Abstract
Purpose: To examine the detection sensitivity for the rapidly exchanging hydroxyl protons of D-glucose using the recently developed on-resonance variable delay multi-pulse (onVDMP) chemical exchange saturation transfer (CEST) technique. Methods: The onVDMP method was applied for the detection of water signal changes upon venous D-glucose infusion in mice with 9L glioma xenografts. The effect size of onVDMP MRI during infusion was compared with that of conventional continuous wave (CW) CEST MRI. Results: Both methods highlighted the tumor and the blood vessels on D-glucose infusion. In interleaved studies, the mean signal changes detected by onVDMP were found to be 1.8 times higher than those by CW-CEST, attributed to its high labeling efficiency for fast exchanging protons and the labeling of the OH protons over a larger frequency range. Conclusions: The onVDMP method is a more sensitive technique for the detection of exogenous CEST agents with fast-exchanging protons compared to CW-CEST MRI.
Original language | English (US) |
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Pages (from-to) | 47-56 |
Number of pages | 10 |
Journal | Magnetic resonance in medicine |
Volume | 81 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2019 |
Keywords
- Chemical exchange
- glioma
- glucoCEST
- on-resonance variable delay multiple pulse (onVDMP)
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging