Glucagon-like peptide-1 regulates the beta cell transcription factor, PDX-1, in insulinoma cells

X. Wang, C. M. Cahill, M. A. Pineyro, J. Zhou, Maire E. Doyle, J. M. Egan

Research output: Contribution to journalArticle

Abstract

Glucagon-like peptide-1 (GLP-1) enhances insulin biosynthesis and secretion as well as transcription of the insulin, GLUT2 and glucokinase genes. The latter are also regulated by the PDX-1 homeoprotein. We investigated the possibility that GLP-1 may be having its long-term pleiotropic effects through a hitherto unknown regulation of PDX-1. We found that PDX-1 mRNA level was significantly increased (p

Original languageEnglish (US)
Pages (from-to)4904-4907
Number of pages4
JournalEndocrinology
Volume140
Issue number10
StatePublished - 1999
Externally publishedYes

Fingerprint

Insulinoma
Glucagon-Like Peptide 1
Transcription Factors
Insulin
Homeodomain Proteins
Glucokinase
Messenger RNA
Genes

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Wang, X., Cahill, C. M., Pineyro, M. A., Zhou, J., Doyle, M. E., & Egan, J. M. (1999). Glucagon-like peptide-1 regulates the beta cell transcription factor, PDX-1, in insulinoma cells. Endocrinology, 140(10), 4904-4907.

Glucagon-like peptide-1 regulates the beta cell transcription factor, PDX-1, in insulinoma cells. / Wang, X.; Cahill, C. M.; Pineyro, M. A.; Zhou, J.; Doyle, Maire E.; Egan, J. M.

In: Endocrinology, Vol. 140, No. 10, 1999, p. 4904-4907.

Research output: Contribution to journalArticle

Wang, X, Cahill, CM, Pineyro, MA, Zhou, J, Doyle, ME & Egan, JM 1999, 'Glucagon-like peptide-1 regulates the beta cell transcription factor, PDX-1, in insulinoma cells', Endocrinology, vol. 140, no. 10, pp. 4904-4907.
Wang, X. ; Cahill, C. M. ; Pineyro, M. A. ; Zhou, J. ; Doyle, Maire E. ; Egan, J. M. / Glucagon-like peptide-1 regulates the beta cell transcription factor, PDX-1, in insulinoma cells. In: Endocrinology. 1999 ; Vol. 140, No. 10. pp. 4904-4907.
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