Glucagon-like peptide 1 and appetite

Megan J. Dailey, Timothy H. Moran

Research output: Contribution to journalReview article

Abstract

Glucagon-like peptide 1 (GLP-1) and GLP-1 analogs have received much recent attention due to the success of GLP-1 mimetics in treating type II diabetes mellitus (T2DM), but these compounds may also have the potential to treat obesity. The satiety effect of GLP-1 may involve both within-meal enteroenteric reflexes, and across-meal central signaling mechanisms, that mediate changes in appetite and promote satiety. Here, we review data supporting the role of both peripheral and central GLP-1 signaling in the control of gastrointestinal motility and food intake. Understanding the mechanisms underlying the appetite-suppressive effects of GLP-1 may help in developing targeted treatments for obesity.

Original languageEnglish (US)
Pages (from-to)85-91
Number of pages7
JournalTrends in Endocrinology and Metabolism
Volume24
Issue number2
DOIs
StatePublished - Feb 1 2013

Keywords

  • Appetite
  • Food intake
  • GLP-1
  • Gastrointestinal motility

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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