In perfused dog hearts, paced at constant rate, the coronary infusion of glucagon was accompanied by an increase in contractility, coronary blood flow (TCBF) and myocardial oxygen consumption (MV̇2). When TCBF was kept constant by lowering coronary perfusion pressure, a similar increase in MV̇O2 could be detected. The O2 cost of a given positive inotropic effect by glucagon did not differ from a comparable one induced by isoprenaline.
- Cardiac performance
- Coronary blood flow
- Myocardial energetics
- Myocardial oxygen consumption
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