TY - JOUR
T1 - Glucagon
T2 - Its effect upon myocardial oxygen consumption
AU - Marsiglia, Juan Carlos
AU - Moreyra, Abel E.
AU - Lardini, Hector
AU - Cingolani, Horacio E.
PY - 1970/11
Y1 - 1970/11
N2 - In perfused dog hearts, paced at constant rate, the coronary infusion of glucagon was accompanied by an increase in contractility, coronary blood flow (TCBF) and myocardial oxygen consumption (MV̇2). When TCBF was kept constant by lowering coronary perfusion pressure, a similar increase in MV̇O2 could be detected. The O2 cost of a given positive inotropic effect by glucagon did not differ from a comparable one induced by isoprenaline.
AB - In perfused dog hearts, paced at constant rate, the coronary infusion of glucagon was accompanied by an increase in contractility, coronary blood flow (TCBF) and myocardial oxygen consumption (MV̇2). When TCBF was kept constant by lowering coronary perfusion pressure, a similar increase in MV̇O2 could be detected. The O2 cost of a given positive inotropic effect by glucagon did not differ from a comparable one induced by isoprenaline.
KW - Cardiac performance
KW - Coronary blood flow
KW - Glucagon
KW - Myocardial energetics
KW - Myocardial oxygen consumption
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U2 - 10.1016/0014-2999(70)90076-2
DO - 10.1016/0014-2999(70)90076-2
M3 - Article
C2 - 5495435
AN - SCOPUS:0014899099
SN - 0014-2999
VL - 12
SP - 265
EP - 270
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 3
ER -