Glucagon: Its effect upon myocardial oxygen consumption

Juan Carlos Marsiglia, Abel E. Moreyra, Hector Lardini, Horacio E. Cingolani

Research output: Contribution to journalArticlepeer-review

Abstract

In perfused dog hearts, paced at constant rate, the coronary infusion of glucagon was accompanied by an increase in contractility, coronary blood flow (TCBF) and myocardial oxygen consumption (MV̇2). When TCBF was kept constant by lowering coronary perfusion pressure, a similar increase in MV̇O2 could be detected. The O2 cost of a given positive inotropic effect by glucagon did not differ from a comparable one induced by isoprenaline.

Original languageEnglish (US)
Pages (from-to)265-270
Number of pages6
JournalEuropean Journal of Pharmacology
Volume12
Issue number3
DOIs
StatePublished - Nov 1970

Keywords

  • Cardiac performance
  • Coronary blood flow
  • Glucagon
  • Myocardial energetics
  • Myocardial oxygen consumption

ASJC Scopus subject areas

  • Pharmacology

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