Abstract
Glucagon-like peptide-1 (GLP-1, 7-36 amide) is an intestinal hormone that is released in response to the luminal presences of nutrients. GLP-1 and related mimetic drugs are potent stimulators of pancreatic insulin, a response that is beneficial for the management of non-insulin dependent diabetes mellitus. Additional investigations have revealed that GLP-1 is an endocrine mediator of the ileal brake and has direct effects on the neural controls of food intake. The overall mechanism of GLP-1 induced food intake suppression is mediated by distinct, but overlapping, peripheral and central systems. GLP-1 is also expressed in the brain and roles for central GLP-1 in feeding control have been proposed. This review will focus on meal-related GLP-1 release, receptor function, synthetic agonists, and peripheral and central mechanism involved in GLP-1 induced inhibition of food intake.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 311-316 |
| Number of pages | 6 |
| Journal | Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry |
| Volume | 8 |
| Issue number | 4 |
| DOIs | |
| State | Published - 2008 |
Keywords
- Aversion
- Byetta
- Exenatide
- Exendin-4
- Incretins
- Liraglutide
- Satiety
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Immunology and Allergy
- Pharmacology