GLP-1 agonists and satiety

Nicholas T. Bello, Timothy H. Moran

Research output: Contribution to journalReview articlepeer-review

Abstract

Glucagon-like peptide-1 (GLP-1, 7-36 amide) is an intestinal hormone that is released in response to the luminal presences of nutrients. GLP-1 and related mimetic drugs are potent stimulators of pancreatic insulin, a response that is beneficial for the management of non-insulin dependent diabetes mellitus. Additional investigations have revealed that GLP-1 is an endocrine mediator of the ileal brake and has direct effects on the neural controls of food intake. The overall mechanism of GLP-1 induced food intake suppression is mediated by distinct, but overlapping, peripheral and central systems. GLP-1 is also expressed in the brain and roles for central GLP-1 in feeding control have been proposed. This review will focus on meal-related GLP-1 release, receptor function, synthetic agonists, and peripheral and central mechanism involved in GLP-1 induced inhibition of food intake.

Original languageEnglish (US)
Pages (from-to)311-316
Number of pages6
JournalImmunology, Endocrine and Metabolic Agents in Medicinal Chemistry
Volume8
Issue number4
DOIs
StatePublished - Dec 1 2008

Keywords

  • Aversion
  • Byetta
  • Exenatide
  • Exendin-4
  • Incretins
  • Liraglutide
  • Satiety

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Pharmacology

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