Globus pallidus volume is related to symptom severity in neuroleptic naive patients with schizophrenia

Ruth Spinks, Peg Nopoulos, Julie Ward, Rebecca Fuller, Vincent A. Magnotta, Nancy C. Andreasen

Research output: Contribution to journalArticle

Abstract

This study compares globus pallidus (GP) volume between neuroleptic naïve patients with schizophrenia and healthy controls using structural MRI. The volume of the external segment of the GP (GPe) was positively correlated with the severity of global symptoms, as measured by the Scale for the Assessment of Negative Symptoms and Scale for the Assessment of Positive Symptoms (SANS/SAPS, Andreasen and Olsen, 1982). The volume for the GP, GPe, and internal segment (GPi) did not differ between groups.

Original languageEnglish (US)
Pages (from-to)229-233
Number of pages5
JournalSchizophrenia Research
Volume73
Issue number2-3
DOIs
StatePublished - Mar 1 2005

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Keywords

  • Globus pallidus
  • MRI
  • Neuroleptic naïve
  • Subcortical structures
  • Symptom severity

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Spinks, R., Nopoulos, P., Ward, J., Fuller, R., Magnotta, V. A., & Andreasen, N. C. (2005). Globus pallidus volume is related to symptom severity in neuroleptic naive patients with schizophrenia. Schizophrenia Research, 73(2-3), 229-233. https://doi.org/10.1016/j.schres.2004.05.020