Global warming will bring new fungal diseases for mammals

Monica A. Garcia-Solache, Arturo Casadevall

Research output: Contribution to journalArticle

Abstract

Fungi are major pathogens of plants, other fungi, rotifers, insects, and amphibians, but relatively few cause disease in mammals. Fungi became important human pathogens only in the late 20th century, primarily in hosts with impaired immunity as a consequence of medical interventions or HIV infection. The relatively high resistance of mammals has been attributed to a combination of a complex immune system and endothermy. Mammals maintain high body temperatures relative to environmental temperatures, creating a thermally restrictive ambient for the majority of fungi. According to this view, protection given by endothermy requires a temperature gradient between those of mammals and the environment. We hypothesize that global warming will increase the prevalence of fungal diseases in mammals by two mechanisms: (i) increasing the geographic range of currently pathogenic species and (ii) selecting for adaptive thermotolerance for species with significant pathogenic potential but currently not pathogenic by virtue of being restricted by mammalian temperatures.

Original languageEnglish (US)
JournalmBio
Volume1
Issue number1
DOIs
StatePublished - Apr 2010
Externally publishedYes

Fingerprint

Global Warming
Mycoses
Mammals
Fungi
Temperature
Amphibians
Body Temperature
HIV Infections
Insects
Immune System
Immunity

ASJC Scopus subject areas

  • Microbiology
  • Virology

Cite this

Global warming will bring new fungal diseases for mammals. / Garcia-Solache, Monica A.; Casadevall, Arturo.

In: mBio, Vol. 1, No. 1, 04.2010.

Research output: Contribution to journalArticle

Garcia-Solache, Monica A. ; Casadevall, Arturo. / Global warming will bring new fungal diseases for mammals. In: mBio. 2010 ; Vol. 1, No. 1.
@article{9a7d05ce4f544c4595ebb491184c1c56,
title = "Global warming will bring new fungal diseases for mammals",
abstract = "Fungi are major pathogens of plants, other fungi, rotifers, insects, and amphibians, but relatively few cause disease in mammals. Fungi became important human pathogens only in the late 20th century, primarily in hosts with impaired immunity as a consequence of medical interventions or HIV infection. The relatively high resistance of mammals has been attributed to a combination of a complex immune system and endothermy. Mammals maintain high body temperatures relative to environmental temperatures, creating a thermally restrictive ambient for the majority of fungi. According to this view, protection given by endothermy requires a temperature gradient between those of mammals and the environment. We hypothesize that global warming will increase the prevalence of fungal diseases in mammals by two mechanisms: (i) increasing the geographic range of currently pathogenic species and (ii) selecting for adaptive thermotolerance for species with significant pathogenic potential but currently not pathogenic by virtue of being restricted by mammalian temperatures.",
author = "Garcia-Solache, {Monica A.} and Arturo Casadevall",
year = "2010",
month = "4",
doi = "10.1128/mBio.00061-10",
language = "English (US)",
volume = "1",
journal = "mBio",
issn = "2161-2129",
publisher = "American Society for Microbiology",
number = "1",

}

TY - JOUR

T1 - Global warming will bring new fungal diseases for mammals

AU - Garcia-Solache, Monica A.

AU - Casadevall, Arturo

PY - 2010/4

Y1 - 2010/4

N2 - Fungi are major pathogens of plants, other fungi, rotifers, insects, and amphibians, but relatively few cause disease in mammals. Fungi became important human pathogens only in the late 20th century, primarily in hosts with impaired immunity as a consequence of medical interventions or HIV infection. The relatively high resistance of mammals has been attributed to a combination of a complex immune system and endothermy. Mammals maintain high body temperatures relative to environmental temperatures, creating a thermally restrictive ambient for the majority of fungi. According to this view, protection given by endothermy requires a temperature gradient between those of mammals and the environment. We hypothesize that global warming will increase the prevalence of fungal diseases in mammals by two mechanisms: (i) increasing the geographic range of currently pathogenic species and (ii) selecting for adaptive thermotolerance for species with significant pathogenic potential but currently not pathogenic by virtue of being restricted by mammalian temperatures.

AB - Fungi are major pathogens of plants, other fungi, rotifers, insects, and amphibians, but relatively few cause disease in mammals. Fungi became important human pathogens only in the late 20th century, primarily in hosts with impaired immunity as a consequence of medical interventions or HIV infection. The relatively high resistance of mammals has been attributed to a combination of a complex immune system and endothermy. Mammals maintain high body temperatures relative to environmental temperatures, creating a thermally restrictive ambient for the majority of fungi. According to this view, protection given by endothermy requires a temperature gradient between those of mammals and the environment. We hypothesize that global warming will increase the prevalence of fungal diseases in mammals by two mechanisms: (i) increasing the geographic range of currently pathogenic species and (ii) selecting for adaptive thermotolerance for species with significant pathogenic potential but currently not pathogenic by virtue of being restricted by mammalian temperatures.

UR - http://www.scopus.com/inward/record.url?scp=77956833630&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77956833630&partnerID=8YFLogxK

U2 - 10.1128/mBio.00061-10

DO - 10.1128/mBio.00061-10

M3 - Article

C2 - 20689745

AN - SCOPUS:77956833630

VL - 1

JO - mBio

JF - mBio

SN - 2161-2129

IS - 1

ER -