Global epidemiology of HIV infection in men who have sex with men

Chris Beyrer, Stefan D. Baral, Frits Van Griensven, Steven M. Goodreau, Suwat Chariyalertsak, Andrea L. Wirtz, Ron Brookmeyer

Research output: Contribution to journalReview articlepeer-review

Abstract

Epidemics of HIV in men who have sex with men (MSM) continue to expand in most countries. We sought to understand the epidemiological drivers of the global epidemic in MSM and why it continues unabated. We did a comprehensive review of available data for HIV prevalence, incidence, risk factors, and the molecular epidemiology of HIV in MSM from 2007 to 2011, and modelled the dynamics of HIV transmission with an agent-based simulation. Our findings show that the high probability of transmission per act through receptive anal intercourse has a central role in explaining the disproportionate disease burden in MSM. HIV can be transmitted through large MSM networks at great speed. Molecular epidemiological data show substantial clustering of HIV infections in MSM networks, and higher rates of dual-variant and multiple-variant HIV infection in MSM than in heterosexual people in the same populations. Prevention strategies that lower biological transmission and acquisition risks, such as approaches based on antiretrovirals, offer promise for controlling the expanding epidemic in MSM, but their potential effectiveness is limited by structural factors that contribute to low health-seeking behaviours in populations of MSM in many parts of the world.

Original languageEnglish (US)
Pages (from-to)367-377
Number of pages11
JournalThe Lancet
Volume380
Issue number9839
DOIs
StatePublished - Jul 2012

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Global epidemiology of HIV infection in men who have sex with men'. Together they form a unique fingerprint.

Cite this