TY - JOUR
T1 - Global elimination of mother-to-child transmission of hepatitis B
T2 - Revisiting the current strategy
AU - Thio, Chloe L.
AU - Guo, Nan
AU - Xie, Chan
AU - Nelson, Kenrad E.
AU - Ehrhardt, Stephan
N1 - Publisher Copyright:
© 2015 Elsevier Ltd.
PY - 2015/8/1
Y1 - 2015/8/1
N2 - Mother-to-child transmission (MTCT) of hepatitis B virus (HBV) is a major route of HBV transmission worldwide despite an existing immunoprophylaxis regimen. The implementation of immunoprophylaxis has been challenging, especially in low-income and middle-income countries, where MTCT is common, because of difficulty obtaining and delivering the monovalent HBV vaccine and the HBV immunoglobulin. Global control of the HBV epidemic will need improved prevention of MTCT. We discuss research gaps that hinder development of new options for the elimination of MTCT as well as policy changes that may help the current vaccine-based strategy to live up to its full potential. We propose that decreasing hepatitis B viral concentrations before delivery, along with HBV vaccine use, could provide an alternative strategy that would decrease MTCT of HBV.
AB - Mother-to-child transmission (MTCT) of hepatitis B virus (HBV) is a major route of HBV transmission worldwide despite an existing immunoprophylaxis regimen. The implementation of immunoprophylaxis has been challenging, especially in low-income and middle-income countries, where MTCT is common, because of difficulty obtaining and delivering the monovalent HBV vaccine and the HBV immunoglobulin. Global control of the HBV epidemic will need improved prevention of MTCT. We discuss research gaps that hinder development of new options for the elimination of MTCT as well as policy changes that may help the current vaccine-based strategy to live up to its full potential. We propose that decreasing hepatitis B viral concentrations before delivery, along with HBV vaccine use, could provide an alternative strategy that would decrease MTCT of HBV.
UR - http://www.scopus.com/inward/record.url?scp=84937734756&partnerID=8YFLogxK
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U2 - 10.1016/S1473-3099(15)00158-9
DO - 10.1016/S1473-3099(15)00158-9
M3 - Comment/debate
C2 - 26145195
AN - SCOPUS:84937734756
SN - 1473-3099
VL - 15
SP - 981
EP - 985
JO - The Lancet Infectious Diseases
JF - The Lancet Infectious Diseases
IS - 8
ER -