TY - JOUR
T1 - Global brain hypoperfusion and oxygenation in amnestic mild cognitive impairment
AU - Liu, Jie
AU - Zhu, Yong Sheng
AU - Khan, Muhammad Ayaz
AU - Brunk, Estee
AU - Martin-Cook, Kristin
AU - Weiner, Myron F.
AU - Cullum, C. Munro
AU - Lu, Hanzhang
AU - Levine, Benjamin D.
AU - Diaz-Arrastia, Ramon
AU - Zhang, Rong
N1 - Funding Information:
This work was support by National Institutes of Health grant R01AG033106-01 and National Institute of Aging grant P30 AG12300 . Jie Liu conducted the statistical analysis and drafted the manuscript; Jie Liu, Yong-Sheng Zhu, and Muhammad Ayaz Khan performed data acquisition, analysis, and interpretation; Estee Brunk and Kristin Martin-Cook performed subject's screening, cognitive data collection, clinical support, and study coordination; Myron F. Weiner, Ramon Diaz-Arrastia, C. Munro Cullum, and Benjamin D. Levine performed clinical diagnosis and support; Ramon Diaz-Arrastia, Hanzhang Lu, and Rong Zhang were involved in the study concept and experimental design, interpretation of data, and study supervision. All authors edited and revised the manuscript and approved final submission with no conflict of interest to disclose. The authors sincerely thank all of the study participants for their willingness, time, and effort devoted to this study and Mr. Kyle Armstrong, Ms. Rosemary Parker, and all members of the study team for their excellent technical support.
PY - 2014/3
Y1 - 2014/3
N2 - Background To determine if global brain hypoperfusion and oxygen hypometabolism occur in patients with amnestic mild cognitive impairment (aMCI). Methods Thirty-two aMCI and 21 normal subjects participated. Total cerebral blood flow (TCBF), cerebral metabolic rate of oxygen (CMRO2), and brain tissue volume were measured using color-coded duplex ultrasonography (CDUS), near-infrared spectroscopy (NIRS), and MRI. TCBF was normalized by total brain tissue volume (TBV) for group comparisons (nTCBF). Cerebrovascular resistance (CVR) was calculated as mean arterial pressure divided by TCBF. Results Reductions in nTCBF by 9%, CMRO2 by 11%, and an increase in CVR by 13% were observed in aMCI relative to normal subjects. No group differences in TBV were observed. nTCBF was correlated with CMRO2 in normal controls, but not in aMCI. Conclusions Global brain hypoperfusion, oxygen hypometabolism, and neurovascular decoupling observed in aMCI suggest that changes in cerebral hemodynamics occur early at a prodromal stage of Alzheimer's disease, which can be assessed using low-cost and bedside-available CDUS and NIRS technology.
AB - Background To determine if global brain hypoperfusion and oxygen hypometabolism occur in patients with amnestic mild cognitive impairment (aMCI). Methods Thirty-two aMCI and 21 normal subjects participated. Total cerebral blood flow (TCBF), cerebral metabolic rate of oxygen (CMRO2), and brain tissue volume were measured using color-coded duplex ultrasonography (CDUS), near-infrared spectroscopy (NIRS), and MRI. TCBF was normalized by total brain tissue volume (TBV) for group comparisons (nTCBF). Cerebrovascular resistance (CVR) was calculated as mean arterial pressure divided by TCBF. Results Reductions in nTCBF by 9%, CMRO2 by 11%, and an increase in CVR by 13% were observed in aMCI relative to normal subjects. No group differences in TBV were observed. nTCBF was correlated with CMRO2 in normal controls, but not in aMCI. Conclusions Global brain hypoperfusion, oxygen hypometabolism, and neurovascular decoupling observed in aMCI suggest that changes in cerebral hemodynamics occur early at a prodromal stage of Alzheimer's disease, which can be assessed using low-cost and bedside-available CDUS and NIRS technology.
KW - Cerebral blood flow
KW - Cerebral metabolic rate of oxygen
KW - MRI
KW - Mild cognitive impairment
KW - Near-infrared spectroscopy
KW - Ultrasonography
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U2 - 10.1016/j.jalz.2013.04.507
DO - 10.1016/j.jalz.2013.04.507
M3 - Article
C2 - 23871763
AN - SCOPUS:84897549756
SN - 1552-5260
VL - 10
SP - 162
EP - 170
JO - Alzheimer's and Dementia
JF - Alzheimer's and Dementia
IS - 2
ER -