Global and organ-specific chronic graft-versus-host disease severity according to the 2005 NIH consensus criteria

Sally Arai, Madan Jagasia, Barry Storer, Xiaoyu Chai, Joseph Pidala, Corey Cutler, Mukta Arora, Daniel J. Weisdorf, Mary E.D. Flowers, Paul J. Martin, Jeanne Palmer, David Jacobsohn, Steven Z. Pavletic, Georgia B. Vogelsang, Stephanie J. Lee

Research output: Contribution to journalArticle

Abstract

In 2005, the National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic GVHD proposed a new scoring system for individual organs and an algorithm for calculating global severity (mild, moderate, severe). The Chronic GVHD Consortium was established to test these new criteria. This report includes the first 298 adult patients enrolled at 5 centers of the Consortium. Patients were assessed every 3-6 months using standardized forms recommended by the Consensus Conference. At the time of study enrollment, global chronic GVHD severity was mild in 10% (n ∇ 32), moderate in 59% (n ∇ 175), and severe in 31% (n ∇ 91). Skin, lung, or eye scores determined the global severity score in the majority of cases, with the other 5 organs determining 16% of the global severity scores. Conventional risk factors predictive for onset of chronic GVHD and nonrelapse mortality in people with chronic GVHD were not associated with NIH global severity scores. Global severity scores at enrollment were associated with nonrelapsemortality (P < .0001) and survival (P < .0001); 2-year overall survival was 62% (severe), 86% (moderate), and 97% (mild). Patients with mild chronic GVHD have a good prognosis, while patients with severe chronic GVHD have a poor prognosis. This study was registered at www.clinicaltrials.gov as no. NCT00637689.

Original languageEnglish (US)
Pages (from-to)4242-4249
Number of pages8
JournalBlood
Volume118
Issue number15
DOIs
StatePublished - Oct 13 2011

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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    Arai, S., Jagasia, M., Storer, B., Chai, X., Pidala, J., Cutler, C., Arora, M., Weisdorf, D. J., Flowers, M. E. D., Martin, P. J., Palmer, J., Jacobsohn, D., Pavletic, S. Z., Vogelsang, G. B., & Lee, S. J. (2011). Global and organ-specific chronic graft-versus-host disease severity according to the 2005 NIH consensus criteria. Blood, 118(15), 4242-4249. https://doi.org/10.1182/blood-2011-03-344390