Global and depth resolved phosphorus magnetic resonance spectroscopy to predict outcome after birth asphyxia

J. Moorcraft, N. M. Bolas, N. K. Ives, R. Ouwerkerk, J. Smyth, B. Rajagopalan, P. L. Hope, G. K. Radda

Research output: Contribution to journalArticlepeer-review

Abstract

Twelve normal and 32 asphyxiated neonates were studied using global and depth resolved phosphorus magnetic resonance spectroscopy (31p MRS). Eight ofthe asphyxiated group died or survived with major neurodevelopmental abnormalities. A global phosphocreatinine/inorganic phosphate (PCr/Pi) ratio below the range of values from normal infants predicted adverse outcome after asphyxia with a positive predictive value of 64%, sensitivity 88%, and specificity 83%. Corresponding values for global inorganic orthophosphate/adenosine triphosphate (Pi/ATP) ratios were positive predictive value 88%, sensitivity 96%, and specificity 88%. Spatiaily localised MRS data, obtained using phase modulated rotating frame imaging, showed cerebral energy metabolism to be more abnormal in deep than superficial regions after birth asphyxia. However, in this population of full term infants none of the regional metabolite concentrations were superior to global data for prediction of outcome.

Original languageEnglish (US)
Pages (from-to)1119-1123
Number of pages5
JournalArchives of Disease in Childhood
Volume66
Issue number10 SPEC NO
DOIs
StatePublished - 1991
Externally publishedYes

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Allergy
  • Pediatrics, Perinatology, and Child Health

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