Global analysis of protein function using protein microarrays

Michael G. Smith, Ghil Jona, Jason Ptacek, Geeta Devgan, Heng Zhu, Xiaowei Zhu, Michael Snyder

Research output: Contribution to journalArticle

Abstract

Protein microarrays containing thousands of proteins arrayed at high density can be prepared and probed for a wide variety of activities, thereby allowing the large scale analysis of many proteins simultaneously. In addition to identifying the activities of many previously uncharacterized proteins, protein microarrays can reveal new activities of well-characterized proteins, thus providing new insights about the functions of these proteins. Below, we describe the construction and use of protein microarrays and their applications using yeast as a model system.

Original languageEnglish (US)
Pages (from-to)171-175
Number of pages5
JournalMechanisms of Ageing and Development
Volume126
Issue number1
DOIs
StatePublished - Jan 1 2005

Keywords

  • Discovery research
  • Genome
  • High-throughput
  • Microarrays
  • Proteomics

ASJC Scopus subject areas

  • Aging
  • Developmental Biology

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  • Cite this

    Smith, M. G., Jona, G., Ptacek, J., Devgan, G., Zhu, H., Zhu, X., & Snyder, M. (2005). Global analysis of protein function using protein microarrays. Mechanisms of Ageing and Development, 126(1), 171-175. https://doi.org/10.1016/j.mad.2004.09.019