GLITTER: A web-based application for gene link inspection through tissue-specific coexpression

Xiangtao Liu, Pengfei Yu, Chao Cheng, James Bennett Potash, Shizhong Han

Research output: Contribution to journalArticle

Abstract

Accumulating evidence supports the polygenic nature of most complex diseases, suggesting the involvement of many susceptibility genes with small effect sizes. Although hundreds of genes may underlie the genetic architecture of complex diseases, those involved in a given disease are probably not randomly distributed, but likely to be functionally related. Protein-protein interaction networks have been used to evaluate the functional relatedness of susceptibility genes. However, these networks do not account for tissue specificity, are limited to protein-coding genes, and are typically biased by incomplete biological knowledge. Here, we present Gene Link Inspector Through Tissue-specific coExpRession (GLITTER), a web-based application for assessing the functional relatedness of susceptibility genes, either coding or noncoding, according to tissue-specific gene expression profiles. GLITTER can also shed light on the specific tissues in which susceptibility genes might exert their functions. We further demonstrate examples of how GLITTER can evaluate the functional relatedness of susceptibility genes underlying schizophrenia and breast cancer, and provide clues about etiology.

Original languageEnglish (US)
Article number33460
JournalScientific Reports
Volume6
DOIs
StatePublished - Sep 14 2016
Externally publishedYes

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Genes
Protein Interaction Maps
Organ Specificity
Transcriptome
Schizophrenia
Proteins
Breast Neoplasms

ASJC Scopus subject areas

  • General

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GLITTER : A web-based application for gene link inspection through tissue-specific coexpression. / Liu, Xiangtao; Yu, Pengfei; Cheng, Chao; Potash, James Bennett; Han, Shizhong.

In: Scientific Reports, Vol. 6, 33460, 14.09.2016.

Research output: Contribution to journalArticle

Liu, Xiangtao ; Yu, Pengfei ; Cheng, Chao ; Potash, James Bennett ; Han, Shizhong. / GLITTER : A web-based application for gene link inspection through tissue-specific coexpression. In: Scientific Reports. 2016 ; Vol. 6.
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