Glial processes, identified through their glial-specific 130 kD surface glycoprotein, are juxtaposed to sites of neurogenesis in the leech germinal plate.

Robert N Cole, R. J. Morell, B. Zipser

Research output: Contribution to journalArticle

Abstract

Glial processes, bearing a unique 130 kD surface protein, are located at key sites of morphogenic movement and neuronal differentiation in the leech germinal plate. A midline glial fascicle resides at the primary axis of embryonic symmetry, alongside which teloblasts move as they generate their bandlets of stem cells. The n-bandlets straddle the midline glia and are known to produce most of the central neuroblasts. The midline glia then defasciculates as neuroblasts begin to aggregate into neuromeres. The defasciculated processes expand into these neuromeres, molding the future central neuropile. Neuroblasts will initiate primary axons toward the midline glia. As the neuromeres mature, midline glial process thin out to demarcate the orientation of the future connectives, which are the major longitudinal axon tracts along the midline. Next, segmental but still primordial glia appear in the neuromeres. Initially, they also project longitudinally, then transversely, demarcating the other two major axonal pathways--the central commissures and peripheral roots. Finally, macroglial processes proliferate as massive axon growth invades the central and peripheral nervous system. Thus, glial processes with different developmental histories accompany different aspects of leech neurogenesis. In other systems, glia have been shown to promote the differentiation and the guidance of neurons. It remains to be seen whether the glial-specific 130 kD protein is a receptor mediating these typical glial functions in the leech germinal plate.

Original languageEnglish (US)
Pages (from-to)446-457
Number of pages12
JournalGLIA
Volume2
Issue number6
StatePublished - 1989
Externally publishedYes

Fingerprint

Leeches
Membrane Glycoproteins
Neurogenesis
Neuroglia
Axons
Neuropil
Peripheral Nervous System
Membrane Proteins
Stem Cells
Central Nervous System

ASJC Scopus subject areas

  • Immunology

Cite this

Glial processes, identified through their glial-specific 130 kD surface glycoprotein, are juxtaposed to sites of neurogenesis in the leech germinal plate. / Cole, Robert N; Morell, R. J.; Zipser, B.

In: GLIA, Vol. 2, No. 6, 1989, p. 446-457.

Research output: Contribution to journalArticle

@article{e0cbaa4c89904b3d8f368f5761cd4b54,
title = "Glial processes, identified through their glial-specific 130 kD surface glycoprotein, are juxtaposed to sites of neurogenesis in the leech germinal plate.",
abstract = "Glial processes, bearing a unique 130 kD surface protein, are located at key sites of morphogenic movement and neuronal differentiation in the leech germinal plate. A midline glial fascicle resides at the primary axis of embryonic symmetry, alongside which teloblasts move as they generate their bandlets of stem cells. The n-bandlets straddle the midline glia and are known to produce most of the central neuroblasts. The midline glia then defasciculates as neuroblasts begin to aggregate into neuromeres. The defasciculated processes expand into these neuromeres, molding the future central neuropile. Neuroblasts will initiate primary axons toward the midline glia. As the neuromeres mature, midline glial process thin out to demarcate the orientation of the future connectives, which are the major longitudinal axon tracts along the midline. Next, segmental but still primordial glia appear in the neuromeres. Initially, they also project longitudinally, then transversely, demarcating the other two major axonal pathways--the central commissures and peripheral roots. Finally, macroglial processes proliferate as massive axon growth invades the central and peripheral nervous system. Thus, glial processes with different developmental histories accompany different aspects of leech neurogenesis. In other systems, glia have been shown to promote the differentiation and the guidance of neurons. It remains to be seen whether the glial-specific 130 kD protein is a receptor mediating these typical glial functions in the leech germinal plate.",
author = "Cole, {Robert N} and Morell, {R. J.} and B. Zipser",
year = "1989",
language = "English (US)",
volume = "2",
pages = "446--457",
journal = "GLIA",
issn = "0894-1491",
publisher = "John Wiley and Sons Inc.",
number = "6",

}

TY - JOUR

T1 - Glial processes, identified through their glial-specific 130 kD surface glycoprotein, are juxtaposed to sites of neurogenesis in the leech germinal plate.

AU - Cole, Robert N

AU - Morell, R. J.

AU - Zipser, B.

PY - 1989

Y1 - 1989

N2 - Glial processes, bearing a unique 130 kD surface protein, are located at key sites of morphogenic movement and neuronal differentiation in the leech germinal plate. A midline glial fascicle resides at the primary axis of embryonic symmetry, alongside which teloblasts move as they generate their bandlets of stem cells. The n-bandlets straddle the midline glia and are known to produce most of the central neuroblasts. The midline glia then defasciculates as neuroblasts begin to aggregate into neuromeres. The defasciculated processes expand into these neuromeres, molding the future central neuropile. Neuroblasts will initiate primary axons toward the midline glia. As the neuromeres mature, midline glial process thin out to demarcate the orientation of the future connectives, which are the major longitudinal axon tracts along the midline. Next, segmental but still primordial glia appear in the neuromeres. Initially, they also project longitudinally, then transversely, demarcating the other two major axonal pathways--the central commissures and peripheral roots. Finally, macroglial processes proliferate as massive axon growth invades the central and peripheral nervous system. Thus, glial processes with different developmental histories accompany different aspects of leech neurogenesis. In other systems, glia have been shown to promote the differentiation and the guidance of neurons. It remains to be seen whether the glial-specific 130 kD protein is a receptor mediating these typical glial functions in the leech germinal plate.

AB - Glial processes, bearing a unique 130 kD surface protein, are located at key sites of morphogenic movement and neuronal differentiation in the leech germinal plate. A midline glial fascicle resides at the primary axis of embryonic symmetry, alongside which teloblasts move as they generate their bandlets of stem cells. The n-bandlets straddle the midline glia and are known to produce most of the central neuroblasts. The midline glia then defasciculates as neuroblasts begin to aggregate into neuromeres. The defasciculated processes expand into these neuromeres, molding the future central neuropile. Neuroblasts will initiate primary axons toward the midline glia. As the neuromeres mature, midline glial process thin out to demarcate the orientation of the future connectives, which are the major longitudinal axon tracts along the midline. Next, segmental but still primordial glia appear in the neuromeres. Initially, they also project longitudinally, then transversely, demarcating the other two major axonal pathways--the central commissures and peripheral roots. Finally, macroglial processes proliferate as massive axon growth invades the central and peripheral nervous system. Thus, glial processes with different developmental histories accompany different aspects of leech neurogenesis. In other systems, glia have been shown to promote the differentiation and the guidance of neurons. It remains to be seen whether the glial-specific 130 kD protein is a receptor mediating these typical glial functions in the leech germinal plate.

UR - http://www.scopus.com/inward/record.url?scp=0024812522&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024812522&partnerID=8YFLogxK

M3 - Article

C2 - 2531725

AN - SCOPUS:0024812522

VL - 2

SP - 446

EP - 457

JO - GLIA

JF - GLIA

SN - 0894-1491

IS - 6

ER -