TY - JOUR
T1 - Glial influences on neural stem cell development
T2 - Cellular niches for adult neurogenesis
AU - Ma, Dengke K.
AU - Ming, Guo Li
AU - Song, Hongjun
PY - 2005/10
Y1 - 2005/10
N2 - Neural stem cells continually generate new neurons in very limited regions of the adult mammalian central nervous system. In the neurogenic regions there are unique and highly specialized microenvironments (niches) that tightly regulate the neuronal development of adult neural stem cells. Emerging evidence suggests that glia, particularly astrocytes, have key roles in controlling multiple steps of adult neurogenesis within the niches, from proliferation and fate specification of neural progenitors to migration and integration of the neuronal progeny into pre-existing neuronal circuits in the adult brain. Identification of specific niche signals that regulate these sequential steps during adult neurogenesis might lead to strategies to induce functional neurogenesis in other brain regions after injury or degenerative neurological diseases.
AB - Neural stem cells continually generate new neurons in very limited regions of the adult mammalian central nervous system. In the neurogenic regions there are unique and highly specialized microenvironments (niches) that tightly regulate the neuronal development of adult neural stem cells. Emerging evidence suggests that glia, particularly astrocytes, have key roles in controlling multiple steps of adult neurogenesis within the niches, from proliferation and fate specification of neural progenitors to migration and integration of the neuronal progeny into pre-existing neuronal circuits in the adult brain. Identification of specific niche signals that regulate these sequential steps during adult neurogenesis might lead to strategies to induce functional neurogenesis in other brain regions after injury or degenerative neurological diseases.
UR - http://www.scopus.com/inward/record.url?scp=25844458514&partnerID=8YFLogxK
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U2 - 10.1016/j.conb.2005.08.003
DO - 10.1016/j.conb.2005.08.003
M3 - Article
C2 - 16144763
AN - SCOPUS:25844458514
SN - 0959-4388
VL - 15
SP - 514
EP - 520
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
IS - 5
ER -