Glaucoma filtration surgery in nonhuman primates using taxol and etoposide in polyanhydride carriers

Henry D Jampel, D. Thibault, K. W. Leong, P. Uppal, Harry A Quigley

Research output: Contribution to journalArticle

Abstract

Purpose. To determine the effect of taxol and etoposide, hydrophobic drugs with antifibrosis activity, on the outcome of filtration surgery in glaucomatous monkeys. Methods. Elevated intraocular pressure was produced bilaterally in eight cynomolgus monkeys by laser treatment of the trabecular meshwork. Four animals subconjunctivally received a polyanhydride disk containing 1 mg etoposide at the time of posterior lip sclerectomy in one eye; the other eye received an identical disk without drug. Similarly, four animals received a disk containing 50 μg of taxol in one eye and a blank disk in the other. Results. Eyes treated with taxol had lower intraocular pressures than control eyes from 20 days after surgery until death. Eyes with satisfactory filtration bleb appearance and patent fistulae on histologic examination had lower intraocular pressures. The intraocular pressure was lower and the duration of success longer in the etoposide-treated eyes (mean, 16 days) compared to that of the fellow eyes (mean, 10 days), but the difference was not statistically significant. Conclusions. Use of polyanhydride disks containing taxol, but not etoposide, had a marked beneficial effect on intraocular pressure and bleb appearance after experimental filtration surgery in monkeys. The difference between the two agents may result from the greater antiproliferative potency of taxol and its greater duration of release from the polymer.

Original languageEnglish (US)
Pages (from-to)3076-3083
Number of pages8
JournalInvestigative Ophthalmology and Visual Science
Volume34
Issue number11
StatePublished - 1993

Fingerprint

Polyanhydrides
Filtering Surgery
Etoposide
Paclitaxel
Glaucoma
Primates
Intraocular Pressure
Blister
Haplorhini
Trabecular Meshwork
Macaca fascicularis
Lip
Ambulatory Surgical Procedures
Pharmaceutical Preparations
Fistula
Polymers
Lasers

Keywords

  • etoposide
  • filtration surgery
  • monkeys
  • polyanhydride
  • taxol

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Glaucoma filtration surgery in nonhuman primates using taxol and etoposide in polyanhydride carriers. / Jampel, Henry D; Thibault, D.; Leong, K. W.; Uppal, P.; Quigley, Harry A.

In: Investigative Ophthalmology and Visual Science, Vol. 34, No. 11, 1993, p. 3076-3083.

Research output: Contribution to journalArticle

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