Girls and boys born before 28 weeks gestation: Risks of cognitive, behavioral, and neurologic outcomes at age 10 years

Karl C.K. Kuban; Robert M. Joseph; Thomas M. O'Shea; Elizabeth N. Allred; Timothy Heeren; Laurie Douglass; Carl E. Stafstrom; Hernan Jara; Jean A. Frazier; Deborah Hirtz; Alan Leviton; Janice Ware; Taryn Coster; Brandi Hanson; Rachel Wilson; Kirsten McGhee; Patricia Lee; Aimee Asgarian; Anjali Sadhwani; Ellen Perrin; Emily Neger; Kathryn Mattern; Jenifer Walkowiak; Susan Barron; Bhavesh Shah; Rachana Singh; Anne Smith; Deborah Klein; Susan McQuiston; Lauren Venuti; Beth Powers; Ann Foley; Brian Dessureau; Molly Wood; Jill Damon-Minow; Richard Ehrenkranz; Jennifer Benjamin; Elaine Romano; Kathy Tsatsanis; Katarzyna Chawarska; Sophy Kim; Susan Dieterich; Karen Bearrs; Nancy Peters; Patricia Brown; Emily Ansusinha; Ellen Waldrep; Jackie Friedman; Gail Hounshell; Debbie Allred; Stephen C. Engelke; Nancy Darden-Saad; Gary Stainback; Diane Warner; Janice Wereszczak; Janice Bernhardt; Joni McKeeman; Echo Meyer; Steve Pastyrnak; Julie Rathbun; Sarah Nota; Teri Crumb; Madeleine Lenski; Deborah Weiland; Megan Lloyd; Scott Hunter; Michael Msall; Rugile Ramoskaite; Suzanne Wiggins; Krissy Washington; Ryan Martin; Barbara Prendergast; Megan Scott; Judith Klarr; Beth Kring; Jennifer Deridder; Kelly Vogt

doi:10.1016/j.jpeds.2016.02.048

Girls and boys born before 28 weeks gestation: Risks of cognitive, behavioral, and neurologic outcomes at age 10 years

Karl C.K. Kuban, Robert M. Joseph, Thomas M. O'Shea, Elizabeth N. Allred, Timothy Heeren, Laurie Douglass, Carl E. Stafstrom, Hernan Jara, Jean A. Frazier, Deborah Hirtz, Alan Leviton, Janice Ware, Taryn Coster, Brandi Hanson, Rachel Wilson, Kirsten McGhee, Patricia Lee, Aimee Asgarian, Anjali Sadhwani, Ellen PerrinEmily Neger, Kathryn Mattern, Jenifer Walkowiak, Susan Barron, Bhavesh Shah, Rachana Singh, Anne Smith, Deborah Klein, Susan McQuiston, Lauren Venuti, Beth Powers, Ann Foley, Brian Dessureau, Molly Wood, Jill Damon-Minow, Richard Ehrenkranz, Jennifer Benjamin, Elaine Romano, Kathy Tsatsanis, Katarzyna Chawarska, Sophy Kim, Susan Dieterich, Karen Bearrs, Nancy Peters, Patricia Brown, Emily Ansusinha, Ellen Waldrep, Jackie Friedman, Gail Hounshell, Debbie Allred, Stephen C. Engelke, Nancy Darden-Saad, Gary Stainback, Diane Warner, Janice Wereszczak, Janice Bernhardt, Joni McKeeman, Echo Meyer, Steve Pastyrnak, Julie Rathbun, Sarah Nota, Teri Crumb, Madeleine Lenski, Deborah Weiland, Megan Lloyd, Scott Hunter, Michael Msall, Rugile Ramoskaite, Suzanne Wiggins, Krissy Washington, Ryan Martin, Barbara Prendergast, Megan Scott, Judith Klarr, Beth Kring, Jennifer Deridder, Kelly Vogt

School of Medicine

Research output: Contribution to journal › Article › peer-review

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Abstract

Objectives To compare the prevalence of cognitive, neurologic, and behavioral outcomes at 10 years of age in 428 girls and 446 boys who were born extremely preterm. Study design A total of 889 of 966 eligible children previously enrolled in the multicenter Extremely Low Gestational Age Newborns Study from 2002-2004 were evaluated at 10 years of age. Children underwent a neuropsychological battery and testing for autism spectrum disorder (ASD), and parents reported on their child's behavior, development, and seizures. Results Of the children, 28% of boys and 21% of girls exhibited moderate to severe impairment on summary measures of cognitive abilities. Boys had a higher prevalence of impairment than girls in nearly all measures of cognition, were more than twice as likely to have microcephaly (15% in boys, 8% in girls), and require more often assistive devices to ambulate (6% in boys, 4% in girls). In contrast, boys and girls had comparable risk for a history of seizure (identified in 10% of the cohort) or epilepsy (identified in 7% of the cohort). The boy-to-girl ratio of ASD (9% in boys, 5% in girls) was lower than expected compared with the overall US autism population. Conclusions In this contemporary cohort of children born extremely premature and evaluated at school age, boys had higher prevalence of cognitive, neurologic, and behavioral deficits than girls. The ratio of boys to girls among those with ASD deserves further study as does the perinatal environmental-genetic interactions that might contribute to male preponderance of deficits in this high-risk sample.

Original language	English (US)
Pages (from-to)	69-75.e1
Journal	Journal of Pediatrics
Volume	173
DOIs	https://doi.org/10.1016/j.jpeds.2016.02.048
State	Published - Jun 1 2016

Keywords

autism
cognition
executive function
extremely low gestational age newborns
late childhood
microcephaly
motor impairment
neurological follow-up

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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10.1016/j.jpeds.2016.02.048

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Kuban, K. C. K., Joseph, R. M., O'Shea, T. M., Allred, E. N., Heeren, T., Douglass, L., Stafstrom, C. E., Jara, H., Frazier, J. A., Hirtz, D., Leviton, A., Ware, J., Coster, T., Hanson, B., Wilson, R., McGhee, K., Lee, P., Asgarian, A., Sadhwani, A., ... Vogt, K. (2016). Girls and boys born before 28 weeks gestation: Risks of cognitive, behavioral, and neurologic outcomes at age 10 years. Journal of Pediatrics, 173, 69-75.e1. https://doi.org/10.1016/j.jpeds.2016.02.048

Kuban, KCK, Joseph, RM, O'Shea, TM, Allred, EN, Heeren, T, Douglass, L, Stafstrom, CE, Jara, H, Frazier, JA, Hirtz, D, Leviton, A, Ware, J, Coster, T, Hanson, B, Wilson, R, McGhee, K, Lee, P, Asgarian, A, Sadhwani, A, Perrin, E, Neger, E, Mattern, K, Walkowiak, J, Barron, S, Shah, B, Singh, R, Smith, A, Klein, D, McQuiston, S, Venuti, L, Powers, B, Foley, A, Dessureau, B, Wood, M, Damon-Minow, J, Ehrenkranz, R, Benjamin, J, Romano, E, Tsatsanis, K, Chawarska, K, Kim, S, Dieterich, S, Bearrs, K, Peters, N, Brown, P, Ansusinha, E, Waldrep, E, Friedman, J, Hounshell, G, Allred, D, Engelke, SC, Darden-Saad, N, Stainback, G, Warner, D, Wereszczak, J, Bernhardt, J, McKeeman, J, Meyer, E, Pastyrnak, S, Rathbun, J, Nota, S, Crumb, T, Lenski, M, Weiland, D, Lloyd, M, Hunter, S, Msall, M, Ramoskaite, R, Wiggins, S, Washington, K, Martin, R, Prendergast, B, Scott, M, Klarr, J, Kring, B, Deridder, J & Vogt, K 2016, 'Girls and boys born before 28 weeks gestation: Risks of cognitive, behavioral, and neurologic outcomes at age 10 years', Journal of Pediatrics, vol. 173, pp. 69-75.e1. https://doi.org/10.1016/j.jpeds.2016.02.048

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title = "Girls and boys born before 28 weeks gestation: Risks of cognitive, behavioral, and neurologic outcomes at age 10 years",

abstract = "Objectives To compare the prevalence of cognitive, neurologic, and behavioral outcomes at 10 years of age in 428 girls and 446 boys who were born extremely preterm. Study design A total of 889 of 966 eligible children previously enrolled in the multicenter Extremely Low Gestational Age Newborns Study from 2002-2004 were evaluated at 10 years of age. Children underwent a neuropsychological battery and testing for autism spectrum disorder (ASD), and parents reported on their child's behavior, development, and seizures. Results Of the children, 28% of boys and 21% of girls exhibited moderate to severe impairment on summary measures of cognitive abilities. Boys had a higher prevalence of impairment than girls in nearly all measures of cognition, were more than twice as likely to have microcephaly (15% in boys, 8% in girls), and require more often assistive devices to ambulate (6% in boys, 4% in girls). In contrast, boys and girls had comparable risk for a history of seizure (identified in 10% of the cohort) or epilepsy (identified in 7% of the cohort). The boy-to-girl ratio of ASD (9% in boys, 5% in girls) was lower than expected compared with the overall US autism population. Conclusions In this contemporary cohort of children born extremely premature and evaluated at school age, boys had higher prevalence of cognitive, neurologic, and behavioral deficits than girls. The ratio of boys to girls among those with ASD deserves further study as does the perinatal environmental-genetic interactions that might contribute to male preponderance of deficits in this high-risk sample.",

keywords = "autism, cognition, executive function, extremely low gestational age newborns, late childhood, microcephaly, motor impairment, neurological follow-up",

author = "Kuban, {Karl C.K.} and Joseph, {Robert M.} and O'Shea, {Thomas M.} and Allred, {Elizabeth N.} and Timothy Heeren and Laurie Douglass and Stafstrom, {Carl E.} and Hernan Jara and Frazier, {Jean A.} and Deborah Hirtz and Alan Leviton and Janice Ware and Taryn Coster and Brandi Hanson and Rachel Wilson and Kirsten McGhee and Patricia Lee and Aimee Asgarian and Anjali Sadhwani and Ellen Perrin and Emily Neger and Kathryn Mattern and Jenifer Walkowiak and Susan Barron and Bhavesh Shah and Rachana Singh and Anne Smith and Deborah Klein and Susan McQuiston and Lauren Venuti and Beth Powers and Ann Foley and Brian Dessureau and Molly Wood and Jill Damon-Minow and Richard Ehrenkranz and Jennifer Benjamin and Elaine Romano and Kathy Tsatsanis and Katarzyna Chawarska and Sophy Kim and Susan Dieterich and Karen Bearrs and Nancy Peters and Patricia Brown and Emily Ansusinha and Ellen Waldrep and Jackie Friedman and Gail Hounshell and Debbie Allred and Engelke, {Stephen C.} and Nancy Darden-Saad and Gary Stainback and Diane Warner and Janice Wereszczak and Janice Bernhardt and Joni McKeeman and Echo Meyer and Steve Pastyrnak and Julie Rathbun and Sarah Nota and Teri Crumb and Madeleine Lenski and Deborah Weiland and Megan Lloyd and Scott Hunter and Michael Msall and Rugile Ramoskaite and Suzanne Wiggins and Krissy Washington and Ryan Martin and Barbara Prendergast and Megan Scott and Judith Klarr and Beth Kring and Jennifer Deridder and Kelly Vogt",

year = "2016",

month = jun,

day = "1",

doi = "10.1016/j.jpeds.2016.02.048",

language = "English (US)",

volume = "173",

pages = "69--75.e1",

journal = "Journal of Pediatrics",

issn = "0022-3476",

publisher = "Mosby Inc.",

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TY - JOUR

T1 - Girls and boys born before 28 weeks gestation

T2 - Risks of cognitive, behavioral, and neurologic outcomes at age 10 years

AU - Kuban, Karl C.K.

AU - Joseph, Robert M.

AU - O'Shea, Thomas M.

AU - Allred, Elizabeth N.

AU - Heeren, Timothy

AU - Douglass, Laurie

AU - Stafstrom, Carl E.

AU - Jara, Hernan

AU - Frazier, Jean A.

AU - Hirtz, Deborah

AU - Leviton, Alan

AU - Ware, Janice

AU - Coster, Taryn

AU - Hanson, Brandi

AU - Wilson, Rachel

AU - McGhee, Kirsten

AU - Lee, Patricia

AU - Asgarian, Aimee

AU - Sadhwani, Anjali

AU - Perrin, Ellen

AU - Neger, Emily

AU - Mattern, Kathryn

AU - Walkowiak, Jenifer

AU - Barron, Susan

AU - Shah, Bhavesh

AU - Singh, Rachana

AU - Smith, Anne

AU - Klein, Deborah

AU - McQuiston, Susan

AU - Venuti, Lauren

AU - Powers, Beth

AU - Foley, Ann

AU - Dessureau, Brian

AU - Wood, Molly

AU - Damon-Minow, Jill

AU - Ehrenkranz, Richard

AU - Benjamin, Jennifer

AU - Romano, Elaine

AU - Tsatsanis, Kathy

AU - Chawarska, Katarzyna

AU - Kim, Sophy

AU - Dieterich, Susan

AU - Bearrs, Karen

AU - Peters, Nancy

AU - Brown, Patricia

AU - Ansusinha, Emily

AU - Waldrep, Ellen

AU - Friedman, Jackie

AU - Hounshell, Gail

AU - Allred, Debbie

AU - Engelke, Stephen C.

AU - Darden-Saad, Nancy

AU - Stainback, Gary

AU - Warner, Diane

AU - Wereszczak, Janice

AU - Bernhardt, Janice

AU - McKeeman, Joni

AU - Meyer, Echo

AU - Pastyrnak, Steve

AU - Rathbun, Julie

AU - Nota, Sarah

AU - Crumb, Teri

AU - Lenski, Madeleine

AU - Weiland, Deborah

AU - Lloyd, Megan

AU - Hunter, Scott

AU - Msall, Michael

AU - Ramoskaite, Rugile

AU - Wiggins, Suzanne

AU - Washington, Krissy

AU - Martin, Ryan

AU - Prendergast, Barbara

AU - Scott, Megan

AU - Klarr, Judith

AU - Kring, Beth

AU - Deridder, Jennifer

AU - Vogt, Kelly

PY - 2016/6/1

Y1 - 2016/6/1

N2 - Objectives To compare the prevalence of cognitive, neurologic, and behavioral outcomes at 10 years of age in 428 girls and 446 boys who were born extremely preterm. Study design A total of 889 of 966 eligible children previously enrolled in the multicenter Extremely Low Gestational Age Newborns Study from 2002-2004 were evaluated at 10 years of age. Children underwent a neuropsychological battery and testing for autism spectrum disorder (ASD), and parents reported on their child's behavior, development, and seizures. Results Of the children, 28% of boys and 21% of girls exhibited moderate to severe impairment on summary measures of cognitive abilities. Boys had a higher prevalence of impairment than girls in nearly all measures of cognition, were more than twice as likely to have microcephaly (15% in boys, 8% in girls), and require more often assistive devices to ambulate (6% in boys, 4% in girls). In contrast, boys and girls had comparable risk for a history of seizure (identified in 10% of the cohort) or epilepsy (identified in 7% of the cohort). The boy-to-girl ratio of ASD (9% in boys, 5% in girls) was lower than expected compared with the overall US autism population. Conclusions In this contemporary cohort of children born extremely premature and evaluated at school age, boys had higher prevalence of cognitive, neurologic, and behavioral deficits than girls. The ratio of boys to girls among those with ASD deserves further study as does the perinatal environmental-genetic interactions that might contribute to male preponderance of deficits in this high-risk sample.

AB - Objectives To compare the prevalence of cognitive, neurologic, and behavioral outcomes at 10 years of age in 428 girls and 446 boys who were born extremely preterm. Study design A total of 889 of 966 eligible children previously enrolled in the multicenter Extremely Low Gestational Age Newborns Study from 2002-2004 were evaluated at 10 years of age. Children underwent a neuropsychological battery and testing for autism spectrum disorder (ASD), and parents reported on their child's behavior, development, and seizures. Results Of the children, 28% of boys and 21% of girls exhibited moderate to severe impairment on summary measures of cognitive abilities. Boys had a higher prevalence of impairment than girls in nearly all measures of cognition, were more than twice as likely to have microcephaly (15% in boys, 8% in girls), and require more often assistive devices to ambulate (6% in boys, 4% in girls). In contrast, boys and girls had comparable risk for a history of seizure (identified in 10% of the cohort) or epilepsy (identified in 7% of the cohort). The boy-to-girl ratio of ASD (9% in boys, 5% in girls) was lower than expected compared with the overall US autism population. Conclusions In this contemporary cohort of children born extremely premature and evaluated at school age, boys had higher prevalence of cognitive, neurologic, and behavioral deficits than girls. The ratio of boys to girls among those with ASD deserves further study as does the perinatal environmental-genetic interactions that might contribute to male preponderance of deficits in this high-risk sample.

KW - autism

KW - cognition

KW - executive function

KW - extremely low gestational age newborns

KW - late childhood

KW - microcephaly

KW - motor impairment

KW - neurological follow-up

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JO - Journal of Pediatrics

JF - Journal of Pediatrics

ER -

Girls and boys born before 28 weeks gestation: Risks of cognitive, behavioral, and neurologic outcomes at age 10 years

Abstract

Keywords

ASJC Scopus subject areas

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