Gilles de la Tourette's disease and minimal brain dysfunction: Amphetamine isomers reveal catecholamine correlates in an affected patient

James L. Meyerhoff, Solomon H. Snyder

Research output: Contribution to journalArticle

Abstract

Graduated doses of d- and l-isomers of amphetamine were administered on several occasions in double blind fashion to a patient with symptoms of both Gilles de la Tourettes disease and minimal brain dysfunction. d-Amphetamine markedly increased the frequency of ticking while l-amphetamine did not alter the tics. By contrast both isomers decreased the patient's hyperactivity to a similar extent. Based on the known differential influence of amphetamine isomers upon brain norepinephrine and dopamine, these findings suggest that aggravation of the tics is mediated by brain norepinephrine, while brain dopamine plays a major role in the alleviation of the symptoms of minimal brain dysfunction.

Original languageEnglish (US)
Pages (from-to)211-220
Number of pages10
JournalPsychopharmacologia
Volume29
Issue number3
DOIs
StatePublished - Sep 1 1973

Keywords

  • Amphetamine
  • Dopamine
  • Hyperactivity
  • Norepinephrine
  • Tics

ASJC Scopus subject areas

  • Pharmacology

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