### Abstract

Many cases of giardiasis in the UK are undiagnosed and among other things, diagnosis is dependent upon the readiness of GPs to request a specimen. The aim of this study is to assess the rate of specimens requested per GP practice in Central Lancashire, to examine the differences between GP practices and to estimate the pattern of unexplained spatial variation in the practice rate of specimens after adjustment for deprivation. To achieve this, we fitted a set of binomial and Poisson regression models, with random effects for GP practice. Our analysis suggests that there were differences in the rate of specimens by GP practices (P <0·001) for a single year, but no difference in the proportion of positive tests per specimen submitted or in the rate of positive specimens per practice population. There was a difference in the cumulative rate of positive specimens per practice population over a 9-year period (P <0·001). Neither the specimen rate per practice for a single year nor the cumulative rate of positive specimens over multiple years demonstrated significant spatial correlation. Hence, spatial variation in the incidence of giardiasis is unlikely to be confounded by variation in GP rate of specimens.

Original language | English (US) |
---|---|

Pages (from-to) | 1692-1701 |

Number of pages | 10 |

Journal | Epidemiology and Infection |

Volume | 143 |

Issue number | 8 |

DOIs | |

State | Published - Mar 15 2015 |

Externally published | Yes |

### Fingerprint

### Keywords

- Diarrhoea
- gastrointestinal infections
- giardiasis
- public health
- water-borne infections

### ASJC Scopus subject areas

- Infectious Diseases
- Epidemiology
- Medicine(all)

### Cite this

*Epidemiology and Infection*,

*143*(8), 1692-1701. https://doi.org/10.1017/S0950268814002350

**Giardiasis in North West England : Faecal specimen requesting rates by GP practice.** / Reeve, N. F.; Fanshawe, T. R.; Lamden, K.; Diggle, P. J.; Cheesbrough, J.; Keegan, T. J.

Research output: Contribution to journal › Article

*Epidemiology and Infection*, vol. 143, no. 8, pp. 1692-1701. https://doi.org/10.1017/S0950268814002350

}

TY - JOUR

T1 - Giardiasis in North West England

T2 - Faecal specimen requesting rates by GP practice

AU - Reeve, N. F.

AU - Fanshawe, T. R.

AU - Lamden, K.

AU - Diggle, P. J.

AU - Cheesbrough, J.

AU - Keegan, T. J.

PY - 2015/3/15

Y1 - 2015/3/15

N2 - Many cases of giardiasis in the UK are undiagnosed and among other things, diagnosis is dependent upon the readiness of GPs to request a specimen. The aim of this study is to assess the rate of specimens requested per GP practice in Central Lancashire, to examine the differences between GP practices and to estimate the pattern of unexplained spatial variation in the practice rate of specimens after adjustment for deprivation. To achieve this, we fitted a set of binomial and Poisson regression models, with random effects for GP practice. Our analysis suggests that there were differences in the rate of specimens by GP practices (P <0·001) for a single year, but no difference in the proportion of positive tests per specimen submitted or in the rate of positive specimens per practice population. There was a difference in the cumulative rate of positive specimens per practice population over a 9-year period (P <0·001). Neither the specimen rate per practice for a single year nor the cumulative rate of positive specimens over multiple years demonstrated significant spatial correlation. Hence, spatial variation in the incidence of giardiasis is unlikely to be confounded by variation in GP rate of specimens.

AB - Many cases of giardiasis in the UK are undiagnosed and among other things, diagnosis is dependent upon the readiness of GPs to request a specimen. The aim of this study is to assess the rate of specimens requested per GP practice in Central Lancashire, to examine the differences between GP practices and to estimate the pattern of unexplained spatial variation in the practice rate of specimens after adjustment for deprivation. To achieve this, we fitted a set of binomial and Poisson regression models, with random effects for GP practice. Our analysis suggests that there were differences in the rate of specimens by GP practices (P <0·001) for a single year, but no difference in the proportion of positive tests per specimen submitted or in the rate of positive specimens per practice population. There was a difference in the cumulative rate of positive specimens per practice population over a 9-year period (P <0·001). Neither the specimen rate per practice for a single year nor the cumulative rate of positive specimens over multiple years demonstrated significant spatial correlation. Hence, spatial variation in the incidence of giardiasis is unlikely to be confounded by variation in GP rate of specimens.

KW - Diarrhoea

KW - gastrointestinal infections

KW - giardiasis

KW - public health

KW - water-borne infections

UR - http://www.scopus.com/inward/record.url?scp=84929165339&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84929165339&partnerID=8YFLogxK

U2 - 10.1017/S0950268814002350

DO - 10.1017/S0950268814002350

M3 - Article

VL - 143

SP - 1692

EP - 1701

JO - Epidemiology and Infection

JF - Epidemiology and Infection

SN - 0950-2688

IS - 8

ER -