Giant myofibroblastoma of the male breast

Syed Z Ali, S. Teichberg, D. C. DeRisi, C. Urmacher

Research output: Contribution to journalArticle

Abstract

Myofibroblastoma of the breast is a rare, benign neoplasm, seen predominantly in men. The gross appearance is that of a well-circumscribed nodule, characteristically small, seldom exceeding 3 cm. We report a case of giant myofibroblastoma measuring 10 cm and weighing 169 g in the breast of an 83-year-old man. Light microscopic, immunohistochemistry, and electron microscopic features are described. Histologically, these neoplasms may exhibit a varied cellularity that can be misinterpreted as sarcoma. However, they lack marked cellular pleomorphism, tumor necrosis, and mitosis and are characteristically composed of plump and long bipolar, spindly cells arranged in swirling fascicles with intervening broad collagen bands. As we report, immunostaining is strongly positive for vimentin, desmin, and muscle common antigen and negative for cytokeratins and S-100-associated protein. Electron microscopy shows predominantly cells suggestive of myofibroblastic differentiation. The patient has remained free of disease 2 years after mastectomy.

Original languageEnglish (US)
Pages (from-to)1170-1176
Number of pages7
JournalAmerican Journal of Surgical Pathology
Volume18
Issue number11
StatePublished - 1994

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Muscle Tissue Neoplasms
Breast
Neoplasms
Desmin
S100 Proteins
Mastectomy
Vimentin
Keratins
Mitosis
Sarcoma
Electron Microscopy
Necrosis
Collagen
Immunohistochemistry
Electrons
Light
Antigens
Muscles

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

Cite this

Ali, S. Z., Teichberg, S., DeRisi, D. C., & Urmacher, C. (1994). Giant myofibroblastoma of the male breast. American Journal of Surgical Pathology, 18(11), 1170-1176.

Giant myofibroblastoma of the male breast. / Ali, Syed Z; Teichberg, S.; DeRisi, D. C.; Urmacher, C.

In: American Journal of Surgical Pathology, Vol. 18, No. 11, 1994, p. 1170-1176.

Research output: Contribution to journalArticle

Ali, SZ, Teichberg, S, DeRisi, DC & Urmacher, C 1994, 'Giant myofibroblastoma of the male breast', American Journal of Surgical Pathology, vol. 18, no. 11, pp. 1170-1176.
Ali SZ, Teichberg S, DeRisi DC, Urmacher C. Giant myofibroblastoma of the male breast. American Journal of Surgical Pathology. 1994;18(11):1170-1176.
Ali, Syed Z ; Teichberg, S. ; DeRisi, D. C. ; Urmacher, C. / Giant myofibroblastoma of the male breast. In: American Journal of Surgical Pathology. 1994 ; Vol. 18, No. 11. pp. 1170-1176.
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