Giant cell arteritis in Asians: A comparative study

Luciano S. Pereira, Michael K. Yoon, Thomas N. Hwang, Jenny E. Hong, Kathyrn Ray, Travis Porco, Timothy J McCulley

Research output: Contribution to journalArticle

Abstract

Background: Giant cell arteritis (GCA) is a common systemic vasculitis, with a presumed Caucasian predominance. The occurrence of GCA in Asians has rarely been addressed. This study aims to assess the incidence of giant cell arteritis in Asians. Methods: In this retrospective review, the self-reported ethnicities of patients with biopsy-proven GCA at the University of California-San Francisco (UCSF) were recorded. Ethnic distribution of the patient population served by UCSF was estimated from an age- and sex-matched control group. The odds ratio for each ethnicity (Asian and Caucasian) was determined and compared using Fisher's exact test and logistic regression analysis. Results: The ethnic distribution of the 38 patients with positive temporal artery biopsies were as follows: Caucasian n=31 (81.6%), Asian n=1 (2.6%) and other n=6 (15.8%). The ethnic distribution of the patient population served by UCSF was as follows: Caucasian 42%, Asian 28% and other 30%. The difference in the proportion of GCA in Asians and Caucasians was statistically significant (OR 0.049 (95% CI 0.0065 to 0.374), p=0.0036). Conclusions: In our patient population, GCA was seen 20 times less frequently in Asian than Caucasian patients. Although this difference is significantly different (p=0.036), given the small sample size and wide CI this should be viewed as a rough estimate.

Original languageEnglish (US)
Pages (from-to)214-216
Number of pages3
JournalBritish Journal of Ophthalmology
Volume95
Issue number2
DOIs
StatePublished - Feb 2011
Externally publishedYes

Fingerprint

Giant Cell Arteritis
San Francisco
Demography
Biopsy
Temporal Arteries
Systemic Vasculitis
Sample Size
Research Design
Logistic Models
Odds Ratio
Regression Analysis
Control Groups
Incidence
Population

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Pereira, L. S., Yoon, M. K., Hwang, T. N., Hong, J. E., Ray, K., Porco, T., & McCulley, T. J. (2011). Giant cell arteritis in Asians: A comparative study. British Journal of Ophthalmology, 95(2), 214-216. https://doi.org/10.1136/bjo.2009.177220

Giant cell arteritis in Asians : A comparative study. / Pereira, Luciano S.; Yoon, Michael K.; Hwang, Thomas N.; Hong, Jenny E.; Ray, Kathyrn; Porco, Travis; McCulley, Timothy J.

In: British Journal of Ophthalmology, Vol. 95, No. 2, 02.2011, p. 214-216.

Research output: Contribution to journalArticle

Pereira, LS, Yoon, MK, Hwang, TN, Hong, JE, Ray, K, Porco, T & McCulley, TJ 2011, 'Giant cell arteritis in Asians: A comparative study', British Journal of Ophthalmology, vol. 95, no. 2, pp. 214-216. https://doi.org/10.1136/bjo.2009.177220
Pereira LS, Yoon MK, Hwang TN, Hong JE, Ray K, Porco T et al. Giant cell arteritis in Asians: A comparative study. British Journal of Ophthalmology. 2011 Feb;95(2):214-216. https://doi.org/10.1136/bjo.2009.177220
Pereira, Luciano S. ; Yoon, Michael K. ; Hwang, Thomas N. ; Hong, Jenny E. ; Ray, Kathyrn ; Porco, Travis ; McCulley, Timothy J. / Giant cell arteritis in Asians : A comparative study. In: British Journal of Ophthalmology. 2011 ; Vol. 95, No. 2. pp. 214-216.
@article{c2ab4e876f734c6d91cbd437304fa465,
title = "Giant cell arteritis in Asians: A comparative study",
abstract = "Background: Giant cell arteritis (GCA) is a common systemic vasculitis, with a presumed Caucasian predominance. The occurrence of GCA in Asians has rarely been addressed. This study aims to assess the incidence of giant cell arteritis in Asians. Methods: In this retrospective review, the self-reported ethnicities of patients with biopsy-proven GCA at the University of California-San Francisco (UCSF) were recorded. Ethnic distribution of the patient population served by UCSF was estimated from an age- and sex-matched control group. The odds ratio for each ethnicity (Asian and Caucasian) was determined and compared using Fisher's exact test and logistic regression analysis. Results: The ethnic distribution of the 38 patients with positive temporal artery biopsies were as follows: Caucasian n=31 (81.6{\%}), Asian n=1 (2.6{\%}) and other n=6 (15.8{\%}). The ethnic distribution of the patient population served by UCSF was as follows: Caucasian 42{\%}, Asian 28{\%} and other 30{\%}. The difference in the proportion of GCA in Asians and Caucasians was statistically significant (OR 0.049 (95{\%} CI 0.0065 to 0.374), p=0.0036). Conclusions: In our patient population, GCA was seen 20 times less frequently in Asian than Caucasian patients. Although this difference is significantly different (p=0.036), given the small sample size and wide CI this should be viewed as a rough estimate.",
author = "Pereira, {Luciano S.} and Yoon, {Michael K.} and Hwang, {Thomas N.} and Hong, {Jenny E.} and Kathyrn Ray and Travis Porco and McCulley, {Timothy J}",
year = "2011",
month = "2",
doi = "10.1136/bjo.2009.177220",
language = "English (US)",
volume = "95",
pages = "214--216",
journal = "British Journal of Ophthalmology",
issn = "0007-1161",
publisher = "BMJ Publishing Group",
number = "2",

}

TY - JOUR

T1 - Giant cell arteritis in Asians

T2 - A comparative study

AU - Pereira, Luciano S.

AU - Yoon, Michael K.

AU - Hwang, Thomas N.

AU - Hong, Jenny E.

AU - Ray, Kathyrn

AU - Porco, Travis

AU - McCulley, Timothy J

PY - 2011/2

Y1 - 2011/2

N2 - Background: Giant cell arteritis (GCA) is a common systemic vasculitis, with a presumed Caucasian predominance. The occurrence of GCA in Asians has rarely been addressed. This study aims to assess the incidence of giant cell arteritis in Asians. Methods: In this retrospective review, the self-reported ethnicities of patients with biopsy-proven GCA at the University of California-San Francisco (UCSF) were recorded. Ethnic distribution of the patient population served by UCSF was estimated from an age- and sex-matched control group. The odds ratio for each ethnicity (Asian and Caucasian) was determined and compared using Fisher's exact test and logistic regression analysis. Results: The ethnic distribution of the 38 patients with positive temporal artery biopsies were as follows: Caucasian n=31 (81.6%), Asian n=1 (2.6%) and other n=6 (15.8%). The ethnic distribution of the patient population served by UCSF was as follows: Caucasian 42%, Asian 28% and other 30%. The difference in the proportion of GCA in Asians and Caucasians was statistically significant (OR 0.049 (95% CI 0.0065 to 0.374), p=0.0036). Conclusions: In our patient population, GCA was seen 20 times less frequently in Asian than Caucasian patients. Although this difference is significantly different (p=0.036), given the small sample size and wide CI this should be viewed as a rough estimate.

AB - Background: Giant cell arteritis (GCA) is a common systemic vasculitis, with a presumed Caucasian predominance. The occurrence of GCA in Asians has rarely been addressed. This study aims to assess the incidence of giant cell arteritis in Asians. Methods: In this retrospective review, the self-reported ethnicities of patients with biopsy-proven GCA at the University of California-San Francisco (UCSF) were recorded. Ethnic distribution of the patient population served by UCSF was estimated from an age- and sex-matched control group. The odds ratio for each ethnicity (Asian and Caucasian) was determined and compared using Fisher's exact test and logistic regression analysis. Results: The ethnic distribution of the 38 patients with positive temporal artery biopsies were as follows: Caucasian n=31 (81.6%), Asian n=1 (2.6%) and other n=6 (15.8%). The ethnic distribution of the patient population served by UCSF was as follows: Caucasian 42%, Asian 28% and other 30%. The difference in the proportion of GCA in Asians and Caucasians was statistically significant (OR 0.049 (95% CI 0.0065 to 0.374), p=0.0036). Conclusions: In our patient population, GCA was seen 20 times less frequently in Asian than Caucasian patients. Although this difference is significantly different (p=0.036), given the small sample size and wide CI this should be viewed as a rough estimate.

UR - http://www.scopus.com/inward/record.url?scp=79251491707&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79251491707&partnerID=8YFLogxK

U2 - 10.1136/bjo.2009.177220

DO - 10.1136/bjo.2009.177220

M3 - Article

C2 - 20584707

AN - SCOPUS:79251491707

VL - 95

SP - 214

EP - 216

JO - British Journal of Ophthalmology

JF - British Journal of Ophthalmology

SN - 0007-1161

IS - 2

ER -