Getting to the point in point-of-care diagnostics for tuberculosis

Elisa H. Ignatius, Keira A. Cohen, William R. Bishai

Research output: Contribution to journalReview articlepeer-review

Abstract

Tuberculosis (TB) continues to affect over 10 million people per year worldwide. Despite advances in diagnosis, smear microscopy insufficiently detects pulmonary disease, with test result reporting taking longer than a day. While urine assays to detect the lipopolysaccharide lipoarabinomannan (LAM), present in mycobacterial cell walls, can provide results within minutes, the currently available assay has low sensitivity and its application is limited to patients with HIV suspected of having TB. In this issue of the JCI, Broger and Nicol et al. investigated 3 rapid urine tests in 372 ambulatory HIV-negative individuals suspected of having TB in South Africa and Peru. FujiLAM emerged as a rapid test to confirm TB diagnosis in the HIV-seronegative population. This study shows that FujiLAM has considerable potential to reshape the TB diagnostics landscape, making diagnosis and treatment in one office visit a reality for TB.

Original languageEnglish (US)
Pages (from-to)5671-5673
Number of pages3
JournalJournal of Clinical Investigation
Volume130
Issue number11
DOIs
StatePublished - Nov 2 2020

ASJC Scopus subject areas

  • Medicine(all)

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