Getting a grip on O-acetyl-ADP-ribose

Kevin G. Hoff, Cynthia Wolberger

Research output: Contribution to journalShort surveypeer-review


Members of the sirtuin protein family link gene silencing and heterochromatin formation to NAD+-dependent histone deacetylation. Two papers now implicate O-acetyl-ADP-ribose, the metabolite produced by this reaction, as a small-molecule effector that binds to heterochromatic proteins.

Original languageEnglish (US)
Pages (from-to)560-561
Number of pages2
JournalNature Structural and Molecular Biology
Issue number7
StatePublished - Jul 1 2005

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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