Abstract
Members of the sirtuin protein family link gene silencing and heterochromatin formation to NAD+-dependent histone deacetylation. Two papers now implicate O-acetyl-ADP-ribose, the metabolite produced by this reaction, as a small-molecule effector that binds to heterochromatic proteins.
Original language | English (US) |
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Pages (from-to) | 560-561 |
Number of pages | 2 |
Journal | Nature Structural and Molecular Biology |
Volume | 12 |
Issue number | 7 |
DOIs | |
State | Published - Jul 2005 |
ASJC Scopus subject areas
- Structural Biology
- Molecular Biology