Getting a grip on O-acetyl-ADP-ribose

Kevin G. Hoff, Cynthia Wolberger

Research output: Contribution to journalShort surveypeer-review

Abstract

Members of the sirtuin protein family link gene silencing and heterochromatin formation to NAD+-dependent histone deacetylation. Two papers now implicate O-acetyl-ADP-ribose, the metabolite produced by this reaction, as a small-molecule effector that binds to heterochromatic proteins.

Original languageEnglish (US)
Pages (from-to)560-561
Number of pages2
JournalNature Structural and Molecular Biology
Volume12
Issue number7
DOIs
StatePublished - Jul 1 2005

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

Fingerprint Dive into the research topics of 'Getting a grip on O-acetyl-ADP-ribose'. Together they form a unique fingerprint.

Cite this