Germline mutations in CDH1 are infrequent in women with early-onset or familial lobular breast cancers

K. A. Schrader, S. Masciari, N. Boyd, C. Salamanca, J. Senz, D. N. Saunders, E. Yorida, S. Maines-Bandiera, P. Kaurah, N. Tung, M. E. Robson, P. D. Ryan, O. I. Olopade, S. M. Domchek, J. Ford, C. Isaacs, P. Brown, J. Balmana, Abdul Rab Razzak, P. MironK. Coffey, M. B. Terry, E. M. John, I. L. Andrulis, J. A. Knight, F. P. O'Malley, M. Daly, P. Bender, R. Moore, M. C. Southey, J. L. Hopper, J. E. Garber, David G. Huntsman

Research output: Contribution to journalArticle

Abstract

Background: Germline mutations in CDH1 are associated with hereditary diffuse gastric cancer; lobular breast cancer also occurs excessively in families with such condition. Method: To determine if CDH1 is a susceptibility gene for lobular breast cancer in women without a family history of diffuse gastric cancer, germline DNA was analysed for the presence of CDH1 mutations in 318 women with lobular breast cancer who were diagnosed before the age of 45 years or had a family history of breast cancer and were not known, or known not, to be carriers of germline mutations in BRCA1 or BRCA2. Cases were ascertained through breast cancer registries and high-risk cancer genetic clinics (Breast Cancer Family Registry, the kConFab and a consortium of breast cancer genetics clinics in the United States and Spain). Additionally, Multiplex Ligation-dependent Probe Amplification was performed for 134 cases to detect large deletions. Results: No truncating mutations and no large deletions were detected. Six non-synonymous variants were found in seven families. Four (4/318 or 1.3%) are considered to be potentially pathogenic through in vitro and in silico analysis. Conclusion: Potentially pathogenic germline CDH1 mutations in women with early-onset or familial lobular breast cancer are at most infrequent.

Original languageEnglish (US)
Pages (from-to)64-68
Number of pages5
JournalJournal of Medical Genetics
Volume48
Issue number1
DOIs
StatePublished - Jan 2011
Externally publishedYes

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Germ-Line Mutation
Breast Neoplasms
Stomach Neoplasms
Registries
Mutation
Multiplex Polymerase Chain Reaction
Familial Breast Cancer
Computer Simulation
Spain
DNA
Genes
Neoplasms

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Schrader, K. A., Masciari, S., Boyd, N., Salamanca, C., Senz, J., Saunders, D. N., ... Huntsman, D. G. (2011). Germline mutations in CDH1 are infrequent in women with early-onset or familial lobular breast cancers. Journal of Medical Genetics, 48(1), 64-68. https://doi.org/10.1136/jmg.2010.079814

Germline mutations in CDH1 are infrequent in women with early-onset or familial lobular breast cancers. / Schrader, K. A.; Masciari, S.; Boyd, N.; Salamanca, C.; Senz, J.; Saunders, D. N.; Yorida, E.; Maines-Bandiera, S.; Kaurah, P.; Tung, N.; Robson, M. E.; Ryan, P. D.; Olopade, O. I.; Domchek, S. M.; Ford, J.; Isaacs, C.; Brown, P.; Balmana, J.; Razzak, Abdul Rab; Miron, P.; Coffey, K.; Terry, M. B.; John, E. M.; Andrulis, I. L.; Knight, J. A.; O'Malley, F. P.; Daly, M.; Bender, P.; Moore, R.; Southey, M. C.; Hopper, J. L.; Garber, J. E.; Huntsman, David G.

In: Journal of Medical Genetics, Vol. 48, No. 1, 01.2011, p. 64-68.

Research output: Contribution to journalArticle

Schrader, KA, Masciari, S, Boyd, N, Salamanca, C, Senz, J, Saunders, DN, Yorida, E, Maines-Bandiera, S, Kaurah, P, Tung, N, Robson, ME, Ryan, PD, Olopade, OI, Domchek, SM, Ford, J, Isaacs, C, Brown, P, Balmana, J, Razzak, AR, Miron, P, Coffey, K, Terry, MB, John, EM, Andrulis, IL, Knight, JA, O'Malley, FP, Daly, M, Bender, P, Moore, R, Southey, MC, Hopper, JL, Garber, JE & Huntsman, DG 2011, 'Germline mutations in CDH1 are infrequent in women with early-onset or familial lobular breast cancers', Journal of Medical Genetics, vol. 48, no. 1, pp. 64-68. https://doi.org/10.1136/jmg.2010.079814
Schrader, K. A. ; Masciari, S. ; Boyd, N. ; Salamanca, C. ; Senz, J. ; Saunders, D. N. ; Yorida, E. ; Maines-Bandiera, S. ; Kaurah, P. ; Tung, N. ; Robson, M. E. ; Ryan, P. D. ; Olopade, O. I. ; Domchek, S. M. ; Ford, J. ; Isaacs, C. ; Brown, P. ; Balmana, J. ; Razzak, Abdul Rab ; Miron, P. ; Coffey, K. ; Terry, M. B. ; John, E. M. ; Andrulis, I. L. ; Knight, J. A. ; O'Malley, F. P. ; Daly, M. ; Bender, P. ; Moore, R. ; Southey, M. C. ; Hopper, J. L. ; Garber, J. E. ; Huntsman, David G. / Germline mutations in CDH1 are infrequent in women with early-onset or familial lobular breast cancers. In: Journal of Medical Genetics. 2011 ; Vol. 48, No. 1. pp. 64-68.
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abstract = "Background: Germline mutations in CDH1 are associated with hereditary diffuse gastric cancer; lobular breast cancer also occurs excessively in families with such condition. Method: To determine if CDH1 is a susceptibility gene for lobular breast cancer in women without a family history of diffuse gastric cancer, germline DNA was analysed for the presence of CDH1 mutations in 318 women with lobular breast cancer who were diagnosed before the age of 45 years or had a family history of breast cancer and were not known, or known not, to be carriers of germline mutations in BRCA1 or BRCA2. Cases were ascertained through breast cancer registries and high-risk cancer genetic clinics (Breast Cancer Family Registry, the kConFab and a consortium of breast cancer genetics clinics in the United States and Spain). Additionally, Multiplex Ligation-dependent Probe Amplification was performed for 134 cases to detect large deletions. Results: No truncating mutations and no large deletions were detected. Six non-synonymous variants were found in seven families. Four (4/318 or 1.3{\%}) are considered to be potentially pathogenic through in vitro and in silico analysis. Conclusion: Potentially pathogenic germline CDH1 mutations in women with early-onset or familial lobular breast cancer are at most infrequent.",
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T1 - Germline mutations in CDH1 are infrequent in women with early-onset or familial lobular breast cancers

AU - Schrader, K. A.

AU - Masciari, S.

AU - Boyd, N.

AU - Salamanca, C.

AU - Senz, J.

AU - Saunders, D. N.

AU - Yorida, E.

AU - Maines-Bandiera, S.

AU - Kaurah, P.

AU - Tung, N.

AU - Robson, M. E.

AU - Ryan, P. D.

AU - Olopade, O. I.

AU - Domchek, S. M.

AU - Ford, J.

AU - Isaacs, C.

AU - Brown, P.

AU - Balmana, J.

AU - Razzak, Abdul Rab

AU - Miron, P.

AU - Coffey, K.

AU - Terry, M. B.

AU - John, E. M.

AU - Andrulis, I. L.

AU - Knight, J. A.

AU - O'Malley, F. P.

AU - Daly, M.

AU - Bender, P.

AU - Moore, R.

AU - Southey, M. C.

AU - Hopper, J. L.

AU - Garber, J. E.

AU - Huntsman, David G.

PY - 2011/1

Y1 - 2011/1

N2 - Background: Germline mutations in CDH1 are associated with hereditary diffuse gastric cancer; lobular breast cancer also occurs excessively in families with such condition. Method: To determine if CDH1 is a susceptibility gene for lobular breast cancer in women without a family history of diffuse gastric cancer, germline DNA was analysed for the presence of CDH1 mutations in 318 women with lobular breast cancer who were diagnosed before the age of 45 years or had a family history of breast cancer and were not known, or known not, to be carriers of germline mutations in BRCA1 or BRCA2. Cases were ascertained through breast cancer registries and high-risk cancer genetic clinics (Breast Cancer Family Registry, the kConFab and a consortium of breast cancer genetics clinics in the United States and Spain). Additionally, Multiplex Ligation-dependent Probe Amplification was performed for 134 cases to detect large deletions. Results: No truncating mutations and no large deletions were detected. Six non-synonymous variants were found in seven families. Four (4/318 or 1.3%) are considered to be potentially pathogenic through in vitro and in silico analysis. Conclusion: Potentially pathogenic germline CDH1 mutations in women with early-onset or familial lobular breast cancer are at most infrequent.

AB - Background: Germline mutations in CDH1 are associated with hereditary diffuse gastric cancer; lobular breast cancer also occurs excessively in families with such condition. Method: To determine if CDH1 is a susceptibility gene for lobular breast cancer in women without a family history of diffuse gastric cancer, germline DNA was analysed for the presence of CDH1 mutations in 318 women with lobular breast cancer who were diagnosed before the age of 45 years or had a family history of breast cancer and were not known, or known not, to be carriers of germline mutations in BRCA1 or BRCA2. Cases were ascertained through breast cancer registries and high-risk cancer genetic clinics (Breast Cancer Family Registry, the kConFab and a consortium of breast cancer genetics clinics in the United States and Spain). Additionally, Multiplex Ligation-dependent Probe Amplification was performed for 134 cases to detect large deletions. Results: No truncating mutations and no large deletions were detected. Six non-synonymous variants were found in seven families. Four (4/318 or 1.3%) are considered to be potentially pathogenic through in vitro and in silico analysis. Conclusion: Potentially pathogenic germline CDH1 mutations in women with early-onset or familial lobular breast cancer are at most infrequent.

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