Germline BCL-2 sequence variants and inherited predisposition to prostate cancer

L. R. Kidd; A. Coulibaly; T. M. Templeton; W. Chen; L. O. Long; T. Mason; C. Bonilla; F. Akereyeni; V. Freeman; W. Isaacs; C. Ahaghotu; R. A. Kittles

doi:10.1038/sj.pcan.4500884

Germline BCL-2 sequence variants and inherited predisposition to prostate cancer

L. R. Kidd, A. Coulibaly, T. M. Templeton, W. Chen, L. O. Long, T. Mason, C. Bonilla, F. Akereyeni, V. Freeman, W. Isaacs, C. Ahaghotu, R. A. Kittles

School of Medicine

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Apoptosis is an essential physiological process that regulates cellular proliferation. Here, we explored the effect of DNA sequence variation within the BCL-2 gene on prostate cancer susceptibility in three clinical populations, consisting of 428 African Americans, 214 Jamaicans and 218 European Americans. We observed a 70% reduced risk for prostate cancer among the European Americans who had possessed two copies of a promoter variant -938C/A. Additionally, common BCL-2 haplotypes appeared to influence prostate cancer risk; however, studies in larger data sets are needed to confirm our findings. Our data suggest that inherited BCL-2 variants may be associated with a decrease in prostate cancer susceptibility.

Original language	English (US)
Pages (from-to)	284-292
Number of pages	9
Journal	Prostate Cancer and Prostatic Diseases
Volume	9
Issue number	3
DOIs	https://doi.org/10.1038/sj.pcan.4500884
State	Published - Sep 2006

Keywords

Apoptosis
Bcl-2
Prostate cancer

ASJC Scopus subject areas

Oncology
Urology
Cancer Research

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10.1038/sj.pcan.4500884

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title = "Germline BCL-2 sequence variants and inherited predisposition to prostate cancer",

abstract = "Apoptosis is an essential physiological process that regulates cellular proliferation. Here, we explored the effect of DNA sequence variation within the BCL-2 gene on prostate cancer susceptibility in three clinical populations, consisting of 428 African Americans, 214 Jamaicans and 218 European Americans. We observed a 70% reduced risk for prostate cancer among the European Americans who had possessed two copies of a promoter variant -938C/A. Additionally, common BCL-2 haplotypes appeared to influence prostate cancer risk; however, studies in larger data sets are needed to confirm our findings. Our data suggest that inherited BCL-2 variants may be associated with a decrease in prostate cancer susceptibility.",

keywords = "Apoptosis, Bcl-2, Prostate cancer",

author = "Kidd, {L. R.} and A. Coulibaly and Templeton, {T. M.} and W. Chen and Long, {L. O.} and T. Mason and C. Bonilla and F. Akereyeni and V. Freeman and W. Isaacs and C. Ahaghotu and Kittles, {R. A.}",

note = "Funding Information: We thank all the men who volunteered to participate in this genetic study. This work was supported by the NIH (1U54CA91431-01), the Department of Defense (DAMD17-00-1-0025 and DAMD 17-02-1-0067) and the Howard University Cancer Center.",

year = "2006",

month = sep,

doi = "10.1038/sj.pcan.4500884",

language = "English (US)",

volume = "9",

pages = "284--292",

journal = "Prostate Cancer and Prostatic Diseases",

issn = "1365-7852",

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T1 - Germline BCL-2 sequence variants and inherited predisposition to prostate cancer

AU - Kidd, L. R.

AU - Coulibaly, A.

AU - Templeton, T. M.

AU - Chen, W.

AU - Long, L. O.

AU - Mason, T.

AU - Bonilla, C.

AU - Akereyeni, F.

AU - Freeman, V.

AU - Isaacs, W.

AU - Ahaghotu, C.

AU - Kittles, R. A.

N1 - Funding Information: We thank all the men who volunteered to participate in this genetic study. This work was supported by the NIH (1U54CA91431-01), the Department of Defense (DAMD17-00-1-0025 and DAMD 17-02-1-0067) and the Howard University Cancer Center.

PY - 2006/9

Y1 - 2006/9

N2 - Apoptosis is an essential physiological process that regulates cellular proliferation. Here, we explored the effect of DNA sequence variation within the BCL-2 gene on prostate cancer susceptibility in three clinical populations, consisting of 428 African Americans, 214 Jamaicans and 218 European Americans. We observed a 70% reduced risk for prostate cancer among the European Americans who had possessed two copies of a promoter variant -938C/A. Additionally, common BCL-2 haplotypes appeared to influence prostate cancer risk; however, studies in larger data sets are needed to confirm our findings. Our data suggest that inherited BCL-2 variants may be associated with a decrease in prostate cancer susceptibility.

AB - Apoptosis is an essential physiological process that regulates cellular proliferation. Here, we explored the effect of DNA sequence variation within the BCL-2 gene on prostate cancer susceptibility in three clinical populations, consisting of 428 African Americans, 214 Jamaicans and 218 European Americans. We observed a 70% reduced risk for prostate cancer among the European Americans who had possessed two copies of a promoter variant -938C/A. Additionally, common BCL-2 haplotypes appeared to influence prostate cancer risk; however, studies in larger data sets are needed to confirm our findings. Our data suggest that inherited BCL-2 variants may be associated with a decrease in prostate cancer susceptibility.

KW - Apoptosis

KW - Bcl-2

KW - Prostate cancer

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ER -

Germline BCL-2 sequence variants and inherited predisposition to prostate cancer

Abstract

Keywords

ASJC Scopus subject areas

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