Germline BCL-2 sequence variants and inherited predisposition to prostate cancer

L. R. Kidd, A. Coulibaly, T. M. Templeton, W. Chen, L. O. Long, T. Mason, C. Bonilla, F. Akereyeni, V. Freeman, William B Isaacs, C. Ahaghotu, R. A. Kittles

Research output: Contribution to journalArticle

Abstract

Apoptosis is an essential physiological process that regulates cellular proliferation. Here, we explored the effect of DNA sequence variation within the BCL-2 gene on prostate cancer susceptibility in three clinical populations, consisting of 428 African Americans, 214 Jamaicans and 218 European Americans. We observed a 70% reduced risk for prostate cancer among the European Americans who had possessed two copies of a promoter variant -938C/A. Additionally, common BCL-2 haplotypes appeared to influence prostate cancer risk; however, studies in larger data sets are needed to confirm our findings. Our data suggest that inherited BCL-2 variants may be associated with a decrease in prostate cancer susceptibility.

Original languageEnglish (US)
Pages (from-to)284-292
Number of pages9
JournalProstate Cancer and Prostatic Diseases
Volume9
Issue number3
DOIs
StatePublished - Sep 2006

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Prostatic Neoplasms
Physiological Phenomena
African Americans
Haplotypes
Cell Proliferation
Apoptosis
Population
Genes

Keywords

  • Apoptosis
  • Bcl-2
  • Prostate cancer

ASJC Scopus subject areas

  • Oncology
  • Urology

Cite this

Kidd, L. R., Coulibaly, A., Templeton, T. M., Chen, W., Long, L. O., Mason, T., ... Kittles, R. A. (2006). Germline BCL-2 sequence variants and inherited predisposition to prostate cancer. Prostate Cancer and Prostatic Diseases, 9(3), 284-292. https://doi.org/10.1038/sj.pcan.4500884

Germline BCL-2 sequence variants and inherited predisposition to prostate cancer. / Kidd, L. R.; Coulibaly, A.; Templeton, T. M.; Chen, W.; Long, L. O.; Mason, T.; Bonilla, C.; Akereyeni, F.; Freeman, V.; Isaacs, William B; Ahaghotu, C.; Kittles, R. A.

In: Prostate Cancer and Prostatic Diseases, Vol. 9, No. 3, 09.2006, p. 284-292.

Research output: Contribution to journalArticle

Kidd, LR, Coulibaly, A, Templeton, TM, Chen, W, Long, LO, Mason, T, Bonilla, C, Akereyeni, F, Freeman, V, Isaacs, WB, Ahaghotu, C & Kittles, RA 2006, 'Germline BCL-2 sequence variants and inherited predisposition to prostate cancer', Prostate Cancer and Prostatic Diseases, vol. 9, no. 3, pp. 284-292. https://doi.org/10.1038/sj.pcan.4500884
Kidd, L. R. ; Coulibaly, A. ; Templeton, T. M. ; Chen, W. ; Long, L. O. ; Mason, T. ; Bonilla, C. ; Akereyeni, F. ; Freeman, V. ; Isaacs, William B ; Ahaghotu, C. ; Kittles, R. A. / Germline BCL-2 sequence variants and inherited predisposition to prostate cancer. In: Prostate Cancer and Prostatic Diseases. 2006 ; Vol. 9, No. 3. pp. 284-292.
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