Germline BCL-2 sequence variants and inherited predisposition to prostate cancer

L. R. Kidd, A. Coulibaly, T. M. Templeton, W. Chen, L. O. Long, T. Mason, C. Bonilla, F. Akereyeni, V. Freeman, W. Isaacs, C. Ahaghotu, R. A. Kittles

Research output: Contribution to journalArticle

Abstract

Apoptosis is an essential physiological process that regulates cellular proliferation. Here, we explored the effect of DNA sequence variation within the BCL-2 gene on prostate cancer susceptibility in three clinical populations, consisting of 428 African Americans, 214 Jamaicans and 218 European Americans. We observed a 70% reduced risk for prostate cancer among the European Americans who had possessed two copies of a promoter variant -938C/A. Additionally, common BCL-2 haplotypes appeared to influence prostate cancer risk; however, studies in larger data sets are needed to confirm our findings. Our data suggest that inherited BCL-2 variants may be associated with a decrease in prostate cancer susceptibility.

Original languageEnglish (US)
Pages (from-to)284-292
Number of pages9
JournalProstate Cancer and Prostatic Diseases
Volume9
Issue number3
DOIs
StatePublished - Sep 1 2006

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Keywords

  • Apoptosis
  • Bcl-2
  • Prostate cancer

ASJC Scopus subject areas

  • Oncology
  • Urology
  • Cancer Research

Cite this

Kidd, L. R., Coulibaly, A., Templeton, T. M., Chen, W., Long, L. O., Mason, T., Bonilla, C., Akereyeni, F., Freeman, V., Isaacs, W., Ahaghotu, C., & Kittles, R. A. (2006). Germline BCL-2 sequence variants and inherited predisposition to prostate cancer. Prostate Cancer and Prostatic Diseases, 9(3), 284-292. https://doi.org/10.1038/sj.pcan.4500884