Germ Cell Tumors Masquerading as Central Nervous System Sarcoidosis

David M. Peeples, Violet Jiji, K. Singh Sahni, Barney Stern

Research output: Contribution to journalArticle

Abstract

The diagnosis of central nervous system sarcoidosis is uncertain without typical multisystem involvement. We describe two patients with isolated central nervous system mass lesions whose biopsy results were consistent with sarcoidosis. After a progressive clinical course, they were found to have diencephalic germinomas. Germ cell tumors, in particular, should be considered in the differential diagnosis of central nervous system sarcoidosis as they are potentially treatable, occur in intracranial locations favored by sarcoidosis mass lesions, and may be surrounded by granulomatous inflammation that can be mistaken for the noncaseating granulomas of sarcoidosis.

Original languageEnglish (US)
Pages (from-to)554-556
Number of pages3
JournalArchives of Neurology
Volume48
Issue number5
DOIs
StatePublished - Jan 1 1991
Externally publishedYes

Fingerprint

Germ Cell and Embryonal Neoplasms
Sarcoidosis
Central Nervous System
Germinoma
Granuloma
Differential Diagnosis
Inflammation
Biopsy
Neurosarcoidosis
Cells
Lesion

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Germ Cell Tumors Masquerading as Central Nervous System Sarcoidosis. / Peeples, David M.; Jiji, Violet; Sahni, K. Singh; Stern, Barney.

In: Archives of Neurology, Vol. 48, No. 5, 01.01.1991, p. 554-556.

Research output: Contribution to journalArticle

Peeples, David M. ; Jiji, Violet ; Sahni, K. Singh ; Stern, Barney. / Germ Cell Tumors Masquerading as Central Nervous System Sarcoidosis. In: Archives of Neurology. 1991 ; Vol. 48, No. 5. pp. 554-556.
@article{18fcf28f8e6d4a6e8cb64703a3398295,
title = "Germ Cell Tumors Masquerading as Central Nervous System Sarcoidosis",
abstract = "The diagnosis of central nervous system sarcoidosis is uncertain without typical multisystem involvement. We describe two patients with isolated central nervous system mass lesions whose biopsy results were consistent with sarcoidosis. After a progressive clinical course, they were found to have diencephalic germinomas. Germ cell tumors, in particular, should be considered in the differential diagnosis of central nervous system sarcoidosis as they are potentially treatable, occur in intracranial locations favored by sarcoidosis mass lesions, and may be surrounded by granulomatous inflammation that can be mistaken for the noncaseating granulomas of sarcoidosis.",
author = "Peeples, {David M.} and Violet Jiji and Sahni, {K. Singh} and Barney Stern",
year = "1991",
month = "1",
day = "1",
doi = "10.1001/archneur.1991.00530170118031",
language = "English (US)",
volume = "48",
pages = "554--556",
journal = "Archives of Neurology",
issn = "0003-9942",
publisher = "American Medical Association",
number = "5",

}

TY - JOUR

T1 - Germ Cell Tumors Masquerading as Central Nervous System Sarcoidosis

AU - Peeples, David M.

AU - Jiji, Violet

AU - Sahni, K. Singh

AU - Stern, Barney

PY - 1991/1/1

Y1 - 1991/1/1

N2 - The diagnosis of central nervous system sarcoidosis is uncertain without typical multisystem involvement. We describe two patients with isolated central nervous system mass lesions whose biopsy results were consistent with sarcoidosis. After a progressive clinical course, they were found to have diencephalic germinomas. Germ cell tumors, in particular, should be considered in the differential diagnosis of central nervous system sarcoidosis as they are potentially treatable, occur in intracranial locations favored by sarcoidosis mass lesions, and may be surrounded by granulomatous inflammation that can be mistaken for the noncaseating granulomas of sarcoidosis.

AB - The diagnosis of central nervous system sarcoidosis is uncertain without typical multisystem involvement. We describe two patients with isolated central nervous system mass lesions whose biopsy results were consistent with sarcoidosis. After a progressive clinical course, they were found to have diencephalic germinomas. Germ cell tumors, in particular, should be considered in the differential diagnosis of central nervous system sarcoidosis as they are potentially treatable, occur in intracranial locations favored by sarcoidosis mass lesions, and may be surrounded by granulomatous inflammation that can be mistaken for the noncaseating granulomas of sarcoidosis.

UR - http://www.scopus.com/inward/record.url?scp=0026160607&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026160607&partnerID=8YFLogxK

U2 - 10.1001/archneur.1991.00530170118031

DO - 10.1001/archneur.1991.00530170118031

M3 - Article

C2 - 1850595

AN - SCOPUS:0026160607

VL - 48

SP - 554

EP - 556

JO - Archives of Neurology

JF - Archives of Neurology

SN - 0003-9942

IS - 5

ER -