Gepirone-ER Treatment of Low Sexual Desire Associated with Depression in Women as Measured by the DeRogatis Inventory of Sexual Function (DISF) Fantasy/Cognition (Desire) Domain-A Post Hoc Analysis

Louis F. Fabre, Louis C. Smith, Leonard Derogatis

Research output: Contribution to journalArticle

Abstract

Introduction. Gepirone-extended release (ER) is effective in treating hypoactive sexual desire disorder (HSDD), as measured by the percent of females with HSDD that no longer met criteria for HSDD treatment. Another approach is to determine treatment effect on sexual desire using a recognized rating scale for sexual function. Because gepirone-ER has antidepressant and anxiolytic effects, investigation of these effects on sexual desire is appropriate. Aim. The aim of this study was to determine whether gepirone-ER has positive effects on sexual desire as measured by the DeRogatis Inventory of Sexual Function (DISF) in a post hoc analysis of 8- and 24-week studies and if this gepirone effect is independent of its antidepressant or anxiolytic activity. Main Outcome Measures. The main outcome measures used for this study were the Hamilton Depression Rating Scale (HAMD-25), change from baseline (CFB), and DISF CFB. Methods: Three hundred thirty-four women selected for depressive symptoms, not sexual dysfunction, received gepirone-ER (40-80mg/day) in a controlled study of atypical depression using the HAMD-25 to measure antidepressant efficacy and a DISF subscale (domain I) to measure sexual cognition/fantasy (desire). After treatment, a 50% reduction from baseline HAMD-25 score identified antidepressant responders. Item 12 of HAMD scale (psychic anxiety) was used to define anxiolytic response scores of 0, 1 as responders, and scores of 2, 3, and 4 as nonresponders. Results: Gepirone-ER had no significant antidepressant or an anxiolytic effect in study 134006; however, DISF results demonstrate that gepirone-ER improves sexual desire in short term (P=0.043) and long term (P=0.006). Both gepirone-ER antidepressant and anxiolytic responders have statistically significant improved sexual desire. Gepirone-ER antidepressant and anxiolytic nonresponders also show statistically significant improvement. Conclusions: In depressed women, gepirone-ER has three mechanisms of action affecting sexual desire: an antidepressant effect, an anxiolytic effect, and a pro-sexual effect. Gepirone-ER improves sexual desire from the 24th to the 50th percentile according to population norms for the DISF. Fabre LF, Smith LC, and DeRogatis LR. Gepirone-ER treatment of low sexual desire associated with depression in women as measured by the DeRogatis inventory of sexual function (DISF) fantasy/cognition (desire) domain-A post Hoc analysis.

Original languageEnglish (US)
Pages (from-to)2569-2581
Number of pages13
JournalJournal of Sexual Medicine
Volume8
Issue number9
DOIs
StatePublished - Sep 2011
Externally publishedYes

Fingerprint

Fantasy
Cognition
Depression
Anti-Anxiety Agents
Equipment and Supplies
Antidepressive Agents
Psychological Sexual Dysfunctions
Therapeutics
gepirone
Outcome Assessment (Health Care)
Anxiety

Keywords

  • 5-HT Agonist
  • Depression
  • DSM-IV Diagnoses of Sexual Disorders
  • Gepirone-ER
  • HSDD
  • Hypoactive Sexual Desire Disorder
  • Low Sexual Interest

ASJC Scopus subject areas

  • Urology
  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

@article{284454f9f174492d94dc1a8dca92e481,
title = "Gepirone-ER Treatment of Low Sexual Desire Associated with Depression in Women as Measured by the DeRogatis Inventory of Sexual Function (DISF) Fantasy/Cognition (Desire) Domain-A Post Hoc Analysis",
abstract = "Introduction. Gepirone-extended release (ER) is effective in treating hypoactive sexual desire disorder (HSDD), as measured by the percent of females with HSDD that no longer met criteria for HSDD treatment. Another approach is to determine treatment effect on sexual desire using a recognized rating scale for sexual function. Because gepirone-ER has antidepressant and anxiolytic effects, investigation of these effects on sexual desire is appropriate. Aim. The aim of this study was to determine whether gepirone-ER has positive effects on sexual desire as measured by the DeRogatis Inventory of Sexual Function (DISF) in a post hoc analysis of 8- and 24-week studies and if this gepirone effect is independent of its antidepressant or anxiolytic activity. Main Outcome Measures. The main outcome measures used for this study were the Hamilton Depression Rating Scale (HAMD-25), change from baseline (CFB), and DISF CFB. Methods: Three hundred thirty-four women selected for depressive symptoms, not sexual dysfunction, received gepirone-ER (40-80mg/day) in a controlled study of atypical depression using the HAMD-25 to measure antidepressant efficacy and a DISF subscale (domain I) to measure sexual cognition/fantasy (desire). After treatment, a 50{\%} reduction from baseline HAMD-25 score identified antidepressant responders. Item 12 of HAMD scale (psychic anxiety) was used to define anxiolytic response scores of 0, 1 as responders, and scores of 2, 3, and 4 as nonresponders. Results: Gepirone-ER had no significant antidepressant or an anxiolytic effect in study 134006; however, DISF results demonstrate that gepirone-ER improves sexual desire in short term (P=0.043) and long term (P=0.006). Both gepirone-ER antidepressant and anxiolytic responders have statistically significant improved sexual desire. Gepirone-ER antidepressant and anxiolytic nonresponders also show statistically significant improvement. Conclusions: In depressed women, gepirone-ER has three mechanisms of action affecting sexual desire: an antidepressant effect, an anxiolytic effect, and a pro-sexual effect. Gepirone-ER improves sexual desire from the 24th to the 50th percentile according to population norms for the DISF. Fabre LF, Smith LC, and DeRogatis LR. Gepirone-ER treatment of low sexual desire associated with depression in women as measured by the DeRogatis inventory of sexual function (DISF) fantasy/cognition (desire) domain-A post Hoc analysis.",
keywords = "5-HT Agonist, Depression, DSM-IV Diagnoses of Sexual Disorders, Gepirone-ER, HSDD, Hypoactive Sexual Desire Disorder, Low Sexual Interest",
author = "Fabre, {Louis F.} and Smith, {Louis C.} and Leonard Derogatis",
year = "2011",
month = "9",
doi = "10.1111/j.1743-6109.2011.02330.x",
language = "English (US)",
volume = "8",
pages = "2569--2581",
journal = "Journal of Sexual Medicine",
issn = "1743-6095",
publisher = "Wiley-Blackwell",
number = "9",

}

TY - JOUR

T1 - Gepirone-ER Treatment of Low Sexual Desire Associated with Depression in Women as Measured by the DeRogatis Inventory of Sexual Function (DISF) Fantasy/Cognition (Desire) Domain-A Post Hoc Analysis

AU - Fabre, Louis F.

AU - Smith, Louis C.

AU - Derogatis, Leonard

PY - 2011/9

Y1 - 2011/9

N2 - Introduction. Gepirone-extended release (ER) is effective in treating hypoactive sexual desire disorder (HSDD), as measured by the percent of females with HSDD that no longer met criteria for HSDD treatment. Another approach is to determine treatment effect on sexual desire using a recognized rating scale for sexual function. Because gepirone-ER has antidepressant and anxiolytic effects, investigation of these effects on sexual desire is appropriate. Aim. The aim of this study was to determine whether gepirone-ER has positive effects on sexual desire as measured by the DeRogatis Inventory of Sexual Function (DISF) in a post hoc analysis of 8- and 24-week studies and if this gepirone effect is independent of its antidepressant or anxiolytic activity. Main Outcome Measures. The main outcome measures used for this study were the Hamilton Depression Rating Scale (HAMD-25), change from baseline (CFB), and DISF CFB. Methods: Three hundred thirty-four women selected for depressive symptoms, not sexual dysfunction, received gepirone-ER (40-80mg/day) in a controlled study of atypical depression using the HAMD-25 to measure antidepressant efficacy and a DISF subscale (domain I) to measure sexual cognition/fantasy (desire). After treatment, a 50% reduction from baseline HAMD-25 score identified antidepressant responders. Item 12 of HAMD scale (psychic anxiety) was used to define anxiolytic response scores of 0, 1 as responders, and scores of 2, 3, and 4 as nonresponders. Results: Gepirone-ER had no significant antidepressant or an anxiolytic effect in study 134006; however, DISF results demonstrate that gepirone-ER improves sexual desire in short term (P=0.043) and long term (P=0.006). Both gepirone-ER antidepressant and anxiolytic responders have statistically significant improved sexual desire. Gepirone-ER antidepressant and anxiolytic nonresponders also show statistically significant improvement. Conclusions: In depressed women, gepirone-ER has three mechanisms of action affecting sexual desire: an antidepressant effect, an anxiolytic effect, and a pro-sexual effect. Gepirone-ER improves sexual desire from the 24th to the 50th percentile according to population norms for the DISF. Fabre LF, Smith LC, and DeRogatis LR. Gepirone-ER treatment of low sexual desire associated with depression in women as measured by the DeRogatis inventory of sexual function (DISF) fantasy/cognition (desire) domain-A post Hoc analysis.

AB - Introduction. Gepirone-extended release (ER) is effective in treating hypoactive sexual desire disorder (HSDD), as measured by the percent of females with HSDD that no longer met criteria for HSDD treatment. Another approach is to determine treatment effect on sexual desire using a recognized rating scale for sexual function. Because gepirone-ER has antidepressant and anxiolytic effects, investigation of these effects on sexual desire is appropriate. Aim. The aim of this study was to determine whether gepirone-ER has positive effects on sexual desire as measured by the DeRogatis Inventory of Sexual Function (DISF) in a post hoc analysis of 8- and 24-week studies and if this gepirone effect is independent of its antidepressant or anxiolytic activity. Main Outcome Measures. The main outcome measures used for this study were the Hamilton Depression Rating Scale (HAMD-25), change from baseline (CFB), and DISF CFB. Methods: Three hundred thirty-four women selected for depressive symptoms, not sexual dysfunction, received gepirone-ER (40-80mg/day) in a controlled study of atypical depression using the HAMD-25 to measure antidepressant efficacy and a DISF subscale (domain I) to measure sexual cognition/fantasy (desire). After treatment, a 50% reduction from baseline HAMD-25 score identified antidepressant responders. Item 12 of HAMD scale (psychic anxiety) was used to define anxiolytic response scores of 0, 1 as responders, and scores of 2, 3, and 4 as nonresponders. Results: Gepirone-ER had no significant antidepressant or an anxiolytic effect in study 134006; however, DISF results demonstrate that gepirone-ER improves sexual desire in short term (P=0.043) and long term (P=0.006). Both gepirone-ER antidepressant and anxiolytic responders have statistically significant improved sexual desire. Gepirone-ER antidepressant and anxiolytic nonresponders also show statistically significant improvement. Conclusions: In depressed women, gepirone-ER has three mechanisms of action affecting sexual desire: an antidepressant effect, an anxiolytic effect, and a pro-sexual effect. Gepirone-ER improves sexual desire from the 24th to the 50th percentile according to population norms for the DISF. Fabre LF, Smith LC, and DeRogatis LR. Gepirone-ER treatment of low sexual desire associated with depression in women as measured by the DeRogatis inventory of sexual function (DISF) fantasy/cognition (desire) domain-A post Hoc analysis.

KW - 5-HT Agonist

KW - Depression

KW - DSM-IV Diagnoses of Sexual Disorders

KW - Gepirone-ER

KW - HSDD

KW - Hypoactive Sexual Desire Disorder

KW - Low Sexual Interest

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U2 - 10.1111/j.1743-6109.2011.02330.x

DO - 10.1111/j.1743-6109.2011.02330.x

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JO - Journal of Sexual Medicine

JF - Journal of Sexual Medicine

SN - 1743-6095

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