Geographic Variation in the Humoral Response to Pneumocystis carinii

A. G. Smulian; D. W. Sullivan; M. J. Linke; N. A. Halsey; T. C. Quinn; A. P. MacPhail; M. A.Hernandez Avila; S. T. Hong; P. D. Walzer; A. G. Smulian; D. W. Sullivan; M. J. Linke; N. A. Halsey; T. C. Quinn; A. P. MacPhail; M. A.Hernandez Avila; S. T. Hong; P. D. Walzer; A. G. Smulian; D. W. Sullivan; M. J. Linke; N. A. Halsey; T. C. Quinn; A. P. MacPhail; M. A.Hernandez Avila; S. T. Hong; P. D. Walzer; A. G. Smulian; D. W. Sullivan; M. J. Linke; N. A. Halsey; T. C. Quinn; A. P. MacPhail; M. A.Hernandez Avila; S. T. Hong; P. D. Walzer; A. G. Smulian; D. W. Sullivan; M. J. Linke; N. A. Halsey; T. C. Quinn; A. P. MacPhail; M. A.Hernandez Avila; S. T. Hong; P. D. Walzer

doi:10.1093/infdis/167.5.1243

Geographic Variation in the Humoral Response to Pneumocystis carinii

A. G. Smulian, D. W. Sullivan, M. J. Linke, N. A. Halsey, T. C. Quinn, A. P. MacPhail, M. A.Hernandez Avila, S. T. Hong, P. D. Walzer, A. G. Smulian, D. W. Sullivan, M. J. Linke, N. A. Halsey, T. C. Quinn, A. P. MacPhail, M. A.Hernandez Avila, S. T. Hong, P. D. Walzer, A. G. Smulian, D. W. SullivanM. J. Linke, N. A. Halsey, T. C. Quinn, A. P. MacPhail, M. A.Hernandez Avila, S. T. Hong, P. D. Walzer, A. G. Smulian, D. W. Sullivan, M. J. Linke, N. A. Halsey, T. C. Quinn, A. P. MacPhail, M. A.Hernandez Avila, S. T. Hong, P. D. Walzer, A. G. Smulian, D. W. Sullivan, M. J. Linke, N. A. Halsey, T. C. Quinn, A. P. MacPhail, M. A.Hernandez Avila, S. T. Hong, P. D. Walzer

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Abstract

The reported incidence of Pneumocystis carinii pneumonia varies in different areas of the world, but little is known about geographic variation in the antibody response to specific antigens. The frequency of anti-P, carinii antibodies in the serum of normal and human immunodeficiency virus (HIV)-infected individuals from five different regions was compared. Serum specimens from 948 subjects were assayed for IgG antibodies to human-derived P. carinii by Western blot. The overall prevalence of anti-P. carinii antibodies was 72.9%. Among HIV-seronegative individuals, the rate of seropositivity was similar in all regions (70.5%-82.4%). Antibodies to the 30- to 40-kDa antigen were most commonly detected. The frequency ofantibodies to high-molecular- mass antigens (95, 120, and 120 kDa) demonstrated significant geographic variation. This study demonstrates that antibody responses to P. carinii are common in all areas studied but vary in frequency and pattern.

Original language	English (US)
Pages (from-to)	1243-1247
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	167
Issue number	5
DOIs	https://doi.org/10.1093/infdis/167.5.1243
State	Published - May 1993

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

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Smulian, A. G., Sullivan, D. W., Linke, M. J., Halsey, N. A., Quinn, T. C., MacPhail, A. P., Avila, M. A. H., Hong, S. T., Walzer, P. D., Smulian, A. G., Sullivan, D. W., Linke, M. J., Halsey, N. A., Quinn, T. C., MacPhail, A. P., Avila, M. A. H., Hong, S. T., Walzer, P. D., Smulian, A. G., ... Walzer, P. D. (1993). Geographic Variation in the Humoral Response to Pneumocystis carinii. Journal of Infectious Diseases, 167(5), 1243-1247. https://doi.org/10.1093/infdis/167.5.1243

Smulian, AG, Sullivan, DW, Linke, MJ, Halsey, NA, Quinn, TC, MacPhail, AP, Avila, MAH, Hong, ST, Walzer, PD, Smulian, AG, Sullivan, DW, Linke, MJ, Halsey, NA, Quinn, TC, MacPhail, AP, Avila, MAH, Hong, ST, Walzer, PD, Smulian, AG, Sullivan, DW, Linke, MJ, Halsey, NA, Quinn, TC, MacPhail, AP, Avila, MAH, Hong, ST, Walzer, PD, Smulian, AG, Sullivan, DW, Linke, MJ, Halsey, NA, Quinn, TC, MacPhail, AP, Avila, MAH, Hong, ST, Walzer, PD, Smulian, AG, Sullivan, DW, Linke, MJ, Halsey, NA, Quinn, TC, MacPhail, AP, Avila, MAH, Hong, ST & Walzer, PD 1993, 'Geographic Variation in the Humoral Response to Pneumocystis carinii', Journal of Infectious Diseases, vol. 167, no. 5, pp. 1243-1247. https://doi.org/10.1093/infdis/167.5.1243

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title = "Geographic Variation in the Humoral Response to Pneumocystis carinii",

abstract = "The reported incidence of Pneumocystis carinii pneumonia varies in different areas of the world, but little is known about geographic variation in the antibody response to specific antigens. The frequency of anti-P, carinii antibodies in the serum of normal and human immunodeficiency virus (HIV)-infected individuals from five different regions was compared. Serum specimens from 948 subjects were assayed for IgG antibodies to human-derived P. carinii by Western blot. The overall prevalence of anti-P. carinii antibodies was 72.9%. Among HIV-seronegative individuals, the rate of seropositivity was similar in all regions (70.5%-82.4%). Antibodies to the 30- to 40-kDa antigen were most commonly detected. The frequency ofantibodies to high-molecular- mass antigens (95, 120, and 120 kDa) demonstrated significant geographic variation. This study demonstrates that antibody responses to P. carinii are common in all areas studied but vary in frequency and pattern.",

author = "Smulian, {A. G.} and Sullivan, {D. W.} and Linke, {M. J.} and Halsey, {N. A.} and Quinn, {T. C.} and MacPhail, {A. P.} and Avila, {M. A.Hernandez} and Hong, {S. T.} and Walzer, {P. D.} and Smulian, {A. G.} and Sullivan, {D. W.} and Linke, {M. J.} and Halsey, {N. A.} and Quinn, {T. C.} and MacPhail, {A. P.} and Avila, {M. A.Hernandez} and Hong, {S. T.} and Walzer, {P. D.} and Smulian, {A. G.} and Sullivan, {D. W.} and Linke, {M. J.} and Halsey, {N. A.} and Quinn, {T. C.} and MacPhail, {A. P.} and Avila, {M. A.Hernandez} and Hong, {S. T.} and Walzer, {P. D.} and Smulian, {A. G.} and Sullivan, {D. W.} and Linke, {M. J.} and Halsey, {N. A.} and Quinn, {T. C.} and MacPhail, {A. P.} and Avila, {M. A.Hernandez} and Hong, {S. T.} and Walzer, {P. D.} and Smulian, {A. G.} and Sullivan, {D. W.} and Linke, {M. J.} and Halsey, {N. A.} and Quinn, {T. C.} and MacPhail, {A. P.} and Avila, {M. A.Hernandez} and Hong, {S. T.} and Walzer, {P. D.}",

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AU - Quinn, T. C.

AU - MacPhail, A. P.

AU - Avila, M. A.Hernandez

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AU - Smulian, A. G.

AU - Sullivan, D. W.

AU - Linke, M. J.

AU - Halsey, N. A.

AU - Quinn, T. C.

AU - MacPhail, A. P.

AU - Avila, M. A.Hernandez

AU - Hong, S. T.

AU - Walzer, P. D.

AU - Smulian, A. G.

AU - Sullivan, D. W.

AU - Linke, M. J.

AU - Halsey, N. A.

AU - Quinn, T. C.

AU - MacPhail, A. P.

AU - Avila, M. A.Hernandez

AU - Hong, S. T.

AU - Walzer, P. D.

AU - Smulian, A. G.

AU - Sullivan, D. W.

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AU - Halsey, N. A.

AU - Quinn, T. C.

AU - MacPhail, A. P.

AU - Avila, M. A.Hernandez

AU - Hong, S. T.

AU - Walzer, P. D.

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N2 - The reported incidence of Pneumocystis carinii pneumonia varies in different areas of the world, but little is known about geographic variation in the antibody response to specific antigens. The frequency of anti-P, carinii antibodies in the serum of normal and human immunodeficiency virus (HIV)-infected individuals from five different regions was compared. Serum specimens from 948 subjects were assayed for IgG antibodies to human-derived P. carinii by Western blot. The overall prevalence of anti-P. carinii antibodies was 72.9%. Among HIV-seronegative individuals, the rate of seropositivity was similar in all regions (70.5%-82.4%). Antibodies to the 30- to 40-kDa antigen were most commonly detected. The frequency ofantibodies to high-molecular- mass antigens (95, 120, and 120 kDa) demonstrated significant geographic variation. This study demonstrates that antibody responses to P. carinii are common in all areas studied but vary in frequency and pattern.

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Geographic Variation in the Humoral Response to Pneumocystis carinii

Abstract

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