Geographic HIV type 1 subtype distribution in Rakai district, Uganda

Aleisha N. Collinson-Streng, Andrew D. Redd, Nelson K. Sewankambo, David Serwadda, Mona Rezapour, Susanna L. Lamers, Ronald H. Gray, Maria J. Wawer, Thomas C. Quinn, Oliver Laeyendecker

Research output: Contribution to journalArticlepeer-review

Abstract

To analyze HIV-1 subtype distribution, sequence analysis was performed on serum specimens obtained in 1994 from the Rakai Health Sciences community cohort in Uganda. Portions of gag-p24 and env-gp41 were sequenced and HIV subtype was determined for 773 subjects residing in 10 community clusters in rural Uganda. Subtypes A (17%) and D (70%) were the most common strains in the population. Subtype distribution varied by geographic region with significantly more subtype A in northern community clusters compared with southern clusters (21% vs. 8%, p < 0.001) and more subtype D in southern clusters compared with northern clusters (78% vs. 65%, p < 0.008). These data illustrate the geographic complexity of subtype variation, which has important implications for HIV-1 vaccine design.

Original languageEnglish (US)
Pages (from-to)1045-1048
Number of pages4
JournalAIDS research and human retroviruses
Volume25
Issue number10
DOIs
StatePublished - Oct 1 2009

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

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