Geographic heterogeneity in the prevalence of human papillomavirus in head and neck cancer

Devasena Anantharaman, Behnoush Abedi-Ardekani, Daniel C. Beachler, Tarik Gheit, Andrew F. Olshan, Kathy Wisniewski, Victor Wunsch-Filho, Tatiana N. Toporcov, Eloiza H. Tajara, José Eduardo Levi, Raquel A. Moyses, Stefania Boccia, Gabriella Cadoni, Guido Rindi, Wolfgang Ahrens, Franco Merletti, David I. Conway, Sylvia Wright, Christine Carreira, Helene RenardPriscilia Chopard, Sandrine McKay-Chopin, Ghislaine Scelo, Massimo Tommasino, Paul Brennan, Gypsyamber D'Souza

Research output: Contribution to journalArticle

Abstract

Human papillomavirus (HPV) causes oropharyngeal squamous cell carcinoma (OPSCC), although strongly divergent results have been reported regarding the prevalence of HPV16 in different countries, whether this represents important differences in etiology remains unclear. Applying rigorous protocols for sample processing, we centrally evaluated 1,420 head and neck tumors (533 oropharynx, 395 oral cavity and 482 larynx) from studies conducted in the US, Europe and Brazil for mucosal HPV DNA and p16INK4a expression to evaluate regional heterogeneity in the proportion of HPV16-associated OPSCC and other head and neck cancer, and to assess covariates associated with the risk of HPV16-positive OPSCC. While majority of OPSCC in the US (60%) were HPV16-positive, this proportion was 31% in Europe and only 4% in Brazil (p < 0.01). Similar differences were observed for other head and neck tumors, ranging from 7% in the US and 5% in Europe, to 0% in South America. The odds of HPV16-positive OPSCC declined with increasing pack years of smoking (OR: 0.75; 95% CI: 0.64–0.87) and drink years of alcohol use (OR: 0.64; 95% CI: 0.54–0.76). These results suggest that while the contribution of HPV16 is substantial for the oropharynx, it remains limited for oral cavity and laryngeal cancers.

Original languageEnglish (US)
Pages (from-to)1968-1975
Number of pages8
JournalInternational Journal of Cancer
Volume140
Issue number9
DOIs
StatePublished - May 1 2017

Fingerprint

Head and Neck Neoplasms
Squamous Cell Carcinoma
Oropharynx
Brazil
Mouth
Neck
Head
Laryngeal Neoplasms
South America
Mouth Neoplasms
Larynx
Neoplasms
Smoking
Alcohols
DNA

Keywords

  • alcohol
  • head and neck cancer
  • HPV16
  • oropharynx
  • prevalence
  • smoking

ASJC Scopus subject areas

  • Medicine(all)
  • Oncology
  • Cancer Research

Cite this

Anantharaman, D., Abedi-Ardekani, B., Beachler, D. C., Gheit, T., Olshan, A. F., Wisniewski, K., ... D'Souza, G. (2017). Geographic heterogeneity in the prevalence of human papillomavirus in head and neck cancer. International Journal of Cancer, 140(9), 1968-1975. https://doi.org/10.1002/ijc.30608

Geographic heterogeneity in the prevalence of human papillomavirus in head and neck cancer. / Anantharaman, Devasena; Abedi-Ardekani, Behnoush; Beachler, Daniel C.; Gheit, Tarik; Olshan, Andrew F.; Wisniewski, Kathy; Wunsch-Filho, Victor; Toporcov, Tatiana N.; Tajara, Eloiza H.; Levi, José Eduardo; Moyses, Raquel A.; Boccia, Stefania; Cadoni, Gabriella; Rindi, Guido; Ahrens, Wolfgang; Merletti, Franco; Conway, David I.; Wright, Sylvia; Carreira, Christine; Renard, Helene; Chopard, Priscilia; McKay-Chopin, Sandrine; Scelo, Ghislaine; Tommasino, Massimo; Brennan, Paul; D'Souza, Gypsyamber.

In: International Journal of Cancer, Vol. 140, No. 9, 01.05.2017, p. 1968-1975.

Research output: Contribution to journalArticle

Anantharaman, D, Abedi-Ardekani, B, Beachler, DC, Gheit, T, Olshan, AF, Wisniewski, K, Wunsch-Filho, V, Toporcov, TN, Tajara, EH, Levi, JE, Moyses, RA, Boccia, S, Cadoni, G, Rindi, G, Ahrens, W, Merletti, F, Conway, DI, Wright, S, Carreira, C, Renard, H, Chopard, P, McKay-Chopin, S, Scelo, G, Tommasino, M, Brennan, P & D'Souza, G 2017, 'Geographic heterogeneity in the prevalence of human papillomavirus in head and neck cancer', International Journal of Cancer, vol. 140, no. 9, pp. 1968-1975. https://doi.org/10.1002/ijc.30608
Anantharaman D, Abedi-Ardekani B, Beachler DC, Gheit T, Olshan AF, Wisniewski K et al. Geographic heterogeneity in the prevalence of human papillomavirus in head and neck cancer. International Journal of Cancer. 2017 May 1;140(9):1968-1975. https://doi.org/10.1002/ijc.30608
Anantharaman, Devasena ; Abedi-Ardekani, Behnoush ; Beachler, Daniel C. ; Gheit, Tarik ; Olshan, Andrew F. ; Wisniewski, Kathy ; Wunsch-Filho, Victor ; Toporcov, Tatiana N. ; Tajara, Eloiza H. ; Levi, José Eduardo ; Moyses, Raquel A. ; Boccia, Stefania ; Cadoni, Gabriella ; Rindi, Guido ; Ahrens, Wolfgang ; Merletti, Franco ; Conway, David I. ; Wright, Sylvia ; Carreira, Christine ; Renard, Helene ; Chopard, Priscilia ; McKay-Chopin, Sandrine ; Scelo, Ghislaine ; Tommasino, Massimo ; Brennan, Paul ; D'Souza, Gypsyamber. / Geographic heterogeneity in the prevalence of human papillomavirus in head and neck cancer. In: International Journal of Cancer. 2017 ; Vol. 140, No. 9. pp. 1968-1975.
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