Genotypic resistance profile of HIV-1 protease gene: A preliminary report from Vellore, south India

Abraham Kandathil, R. Kannangai, O. Abraham, T. Sudarsanam, S. Pulimood, G. Sridharan

Research output: Contribution to journalArticle

Abstract

HIV-1 subtypes other than B are responsible for most new HIV infections worldwide; virus sequence data for drug resistance is described only from a limited number of non-B subtype HIV-1. This study is on mutations and polymorphisms of HIV-1 protease gene that can predict drug resistance in subtype C. The genotypic resistance assay was carried out on 38 HIV-1 strains with their plasma RNA and in nine, the proviral protease gene was sequenced. The treatment naïve strains showed minor resistance mutations, there were no major resistance mutations in the protease gene. We suggest the use of resistance testing to monitor individuals on therapy and also before initiation of therapy, gathering more sequence information for a data bank of Indian strains.

Original languageEnglish (US)
Pages (from-to)151-154
Number of pages4
JournalIndian Journal of Medical Microbiology
Volume26
Issue number2
DOIs
StatePublished - Apr 1 2008
Externally publishedYes

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HIV-1
India
Drug Resistance
Mutation
Peptide Hydrolases
Genes
HIV Infections
Databases
RNA
Viruses
Therapeutics
Human immunodeficiency virus 1 p16 protease

Keywords

  • Drug resistance
  • HIV-1
  • India
  • Protease gene mutations

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

Genotypic resistance profile of HIV-1 protease gene : A preliminary report from Vellore, south India. / Kandathil, Abraham; Kannangai, R.; Abraham, O.; Sudarsanam, T.; Pulimood, S.; Sridharan, G.

In: Indian Journal of Medical Microbiology, Vol. 26, No. 2, 01.04.2008, p. 151-154.

Research output: Contribution to journalArticle

Kandathil, Abraham ; Kannangai, R. ; Abraham, O. ; Sudarsanam, T. ; Pulimood, S. ; Sridharan, G. / Genotypic resistance profile of HIV-1 protease gene : A preliminary report from Vellore, south India. In: Indian Journal of Medical Microbiology. 2008 ; Vol. 26, No. 2. pp. 151-154.
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