Genotype influences in vivo dopamine transporter availability in human striatum

Andreas Heinz, David Goldman, Douglas W. Jones, Roberta Palmour, Dan Hommer, Julia G. Gorey, Kan S. Lee, Markku Linnoila, Daniel R. Weinberger

Research output: Contribution to journalArticlepeer-review

Abstract

In vivo availability of striatal dopamine transporter (DAT) protein has been reported to be reduced among alcoholics, and allelic variation of the DAT gene (SLC6A3) has been associated with severity of alcohol withdrawal. We examined the VNTR polymorphism of the 3' untranslated region of SLC6A3 and DAT protein availability in 14 abstinent alcoholics and 11 control subjects. Single photon emission computed tomography (SPECT) and plasma levels of the radioligand [I-123]β-CIT were used to quantify DAT protein availability. Individuals with the 9-repeat/10-repeat genotype had a mean 22% reduction of DAT protein availability in putamen compared with 10-repeat homozygous individuals (t = 2.14, df = 23, p < .05). Consistent with earlier studies, alcoholism, per se, was not significantly associated with either DAT availability or DAT genotype. These findings suggest that the VNTR polymorphism of the DAT gene effects translation of the DAT protein. This effect may explain a variety of clinical associations that have been reported with this polymorphism. Copyright (C) 2000 American College of Neuropsychopharmacology.

Original languageEnglish (US)
Pages (from-to)133-139
Number of pages7
JournalNeuropsychopharmacology
Volume22
Issue number2
DOIs
StatePublished - Feb 2000
Externally publishedYes

Keywords

  • Alcoholism
  • Dopamine transporter
  • Gene expression
  • SLC6A3
  • SPECT
  • β-CIT

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

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