Genomics of Peritoneal Malignancies

Enusha Karunasena, Jonathan Sham, Kevin Wyatt McMahon, Nita Ahuja

Research output: Contribution to journalReview articlepeer-review

Abstract

The peritoneum protects the intraabdominal organs. This function is exploited by aggressive cancers originating from organs within the abdomen, resulting in peritoneal metastasis. We discuss genomic variants that may lead to peritoneal metastasis from multiple cancers. Peritoneal malignancies are attributed to epithelial-mesenchymal transition. These metastatic lesions harbor similar genetic mutations to the primary tumor yet may manifest clone-specific aberrations that promote propagation. Peritoneal metastasis are increasingly being treated with surgical resection as an adjunct to radiation, chemotherapy, and other biologic therapies. We describe genetic and genomic variances that are predictive markers for metastasis and burgeoning indicators for peritoneal malignancies.

Original languageEnglish (US)
Pages (from-to)463-475
Number of pages13
JournalSurgical Oncology Clinics of North America
Volume27
Issue number3
DOIs
StatePublished - Jul 1 2018

Keywords

  • Colorectal
  • Epigenetics
  • Genomics
  • Microarray
  • Mutations
  • Ovarian
  • Pancreatic
  • Sequencing

ASJC Scopus subject areas

  • Surgery
  • Oncology

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