Genomics of long-range regulatory elements

James P. Noonan, Andrew S. McCallion

Research output: Contribution to journalReview articlepeer-review

Abstract

Transcriptional regulation of gene expression plays a significant role in establishing the diversity of human cell types and biological functions from a common set of genes. The components of regulatory control in the human genome include cis-acting elements that act across immense genomic distances to influence the spatial and temporal distribution of gene expression. Here we review the established categories of distant-acting regulatory elements, discussing the classical and contemporary evidence of their regulatory potential and clinical importance. Current efforts to identify regulatory sequences throughout the genome and elucidate their biological significance depend heavily on advances in sequence conservation-based analyses and on increasingly large-scale efforts applying transgenic technologies in model organisms. We discuss the advantages and limitations of sequence conservation as a predictor of regulatory function and present complementary emerging technologies now being applied to annotate regulatory elements in vertebrate genomes.

Original languageEnglish (US)
Pages (from-to)1-23
Number of pages23
JournalAnnual Review of Genomics and Human Genetics
Volume11
DOIs
StatePublished - Sep 22 2010

Keywords

  • chromatin
  • conservation
  • development
  • enhancer
  • insulator
  • long-range regulation
  • repressor

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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