Genomics of fibromyalgia

This chapter describes investigations that explored the genomic correlates of fibromyalgia. Significance and prevalence rates are reviewed and definitions are discussed within the context of the need to develop case definitions and phenotypes to advance the science and management of fibromyalgia. Underlying mechanisms and several clinical practice guidelines are presented. A summary of recommendations regarding assessment and management of fibromyalgia, drawn from the guidelines, is listed with particular emphasis on the co-management of co-occurring symptoms and conditions such as deconditioning and muscle weakness, lack of energy, pain, emotional distress, cognitive impairment, sleep disturbance/insomnia, and nutrition-related issues. The chapter concludes with a brief discussion about the significance of these genomic correlates of fibromyalgia recommending potential research topics to pursue in order to fill the existing gaps in knowledge.