Genomic structure and promoter analysis of the human obese gene

Da Wei Gong, Sheng Bi, Richard E. Pratley, Bruce D. Weintraub

Research output: Contribution to journalArticlepeer-review


The human gene encoding the homolog of the mouse obese (ob) gene was isolated and partially characterized. The human ob gene consists of three exons and two introns and spans about 18 kilobase pairs (kb), encoding a 3.5- kb cDNA. A 3-kb 5'-flanking region of the gene was cloned and transient transfection assay with luciferase reporter confirmed the promoter activity in differentiated F442-A adipocytes. Potential regulatory elements are discussed in this report.

Original languageEnglish (US)
Pages (from-to)3971-3974
Number of pages4
JournalJournal of Biological Chemistry
Issue number8
StatePublished - Feb 23 1996
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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