Genomic landscapes of pancreatic neoplasia

Laura D. Wood; Ralph H. Hruban

doi:10.4132/jptm.2014.12.26

Genomic landscapes of pancreatic neoplasia

Laura D. Wood, Ralph H. Hruban

School of Medicine

Research output: Contribution to journal › Review article › peer-review

13 Scopus citations

Abstract

Pancreatic cancer is a deadly disease with a dismal prognosis. However, recent advances in sequencing and bioinformatic technology have led to the systematic characterization of the genomes of all major tumor types in the pancreas. This characterization has revealed the unique genomic landscape of each tumor type. This knowledge will pave the way for improved diagnostic and therapeutic approaches to pancreatic tumors that take advantage of the genetic alterations in these neoplasms.

Original language	English (US)
Pages (from-to)	13-22
Number of pages	10
Journal	Journal of Pathology and Translational Medicine
Volume	49
Issue number	1
DOIs	https://doi.org/10.4132/jptm.2014.12.26
State	Published - 2015

Keywords

Cancer genomics
Cancer mutation
Pancreatic neoplasms

ASJC Scopus subject areas

Pathology and Forensic Medicine
Histology

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10.4132/jptm.2014.12.26

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title = "Genomic landscapes of pancreatic neoplasia",

abstract = "Pancreatic cancer is a deadly disease with a dismal prognosis. However, recent advances in sequencing and bioinformatic technology have led to the systematic characterization of the genomes of all major tumor types in the pancreas. This characterization has revealed the unique genomic landscape of each tumor type. This knowledge will pave the way for improved diagnostic and therapeutic approaches to pancreatic tumors that take advantage of the genetic alterations in these neoplasms.",

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AU - Hruban, Ralph H.

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AB - Pancreatic cancer is a deadly disease with a dismal prognosis. However, recent advances in sequencing and bioinformatic technology have led to the systematic characterization of the genomes of all major tumor types in the pancreas. This characterization has revealed the unique genomic landscape of each tumor type. This knowledge will pave the way for improved diagnostic and therapeutic approaches to pancreatic tumors that take advantage of the genetic alterations in these neoplasms.

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KW - Cancer mutation

KW - Pancreatic neoplasms

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Genomic landscapes of pancreatic neoplasia

Abstract

Keywords

ASJC Scopus subject areas

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