Genomic instability and mitochondrial homeostasis in cancer: does chromatin have a say?

Yue Liu, Haojian Li, Susan E. Zimmerman, Urbain Weyemi

Research output: Contribution to journalComment/debatepeer-review

Abstract

While genomic instability and mitochondrial homeostasis are integral for cancer progression, how these two hallmarks interact remains poorly understood. Here, we reflect on the dialogue between chromatin-based genomic instability and impairment of mitochondrial function and depict the importance of this interaction in cancer progression to metastasis.

Original languageEnglish (US)
Article number1771959
JournalMolecular and Cellular Oncology
DOIs
StatePublished - 2020

Keywords

  • Genomic instability
  • cancer
  • chromatin
  • metabolism
  • mitochondrial homeostasis

ASJC Scopus subject areas

  • Molecular Medicine
  • Cancer Research

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