Genomic instability and mitochondrial homeostasis in cancer: does chromatin have a say?

Yue Liu; Haojian Li; Susan E. Zimmerman; Urbain Weyemi

doi:10.1080/23723556.2020.1771959

Genomic instability and mitochondrial homeostasis in cancer: does chromatin have a say?

Yue Liu, Haojian Li, Susan E. Zimmerman, Urbain Weyemi

School of Medicine

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

While genomic instability and mitochondrial homeostasis are integral for cancer progression, how these two hallmarks interact remains poorly understood. Here, we reflect on the dialogue between chromatin-based genomic instability and impairment of mitochondrial function and depict the importance of this interaction in cancer progression to metastasis.

Original language	English (US)
Article number	1771959
Journal	Molecular and Cellular Oncology
DOIs	https://doi.org/10.1080/23723556.2020.1771959
State	Published - 2020

Keywords

Genomic instability
cancer
chromatin
metabolism
mitochondrial homeostasis

ASJC Scopus subject areas

Molecular Medicine
Cancer Research

Access to Document

10.1080/23723556.2020.1771959

Cite this

@article{b45ef7dee9ac41188951d39c97f06636,

title = "Genomic instability and mitochondrial homeostasis in cancer: does chromatin have a say?",

abstract = "While genomic instability and mitochondrial homeostasis are integral for cancer progression, how these two hallmarks interact remains poorly understood. Here, we reflect on the dialogue between chromatin-based genomic instability and impairment of mitochondrial function and depict the importance of this interaction in cancer progression to metastasis.",

keywords = "Genomic instability, cancer, chromatin, metabolism, mitochondrial homeostasis",

author = "Yue Liu and Haojian Li and Zimmerman, {Susan E.} and Urbain Weyemi",

note = "Publisher Copyright: {\textcopyright} 2020, {\textcopyright} 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.",

year = "2020",

doi = "10.1080/23723556.2020.1771959",

language = "English (US)",

journal = "Molecular and Cellular Oncology",

issn = "2372-3556",

publisher = "Taylor and Francis Ltd.",

}

TY - JOUR

T1 - Genomic instability and mitochondrial homeostasis in cancer

T2 - does chromatin have a say?

AU - Liu, Yue

AU - Li, Haojian

AU - Zimmerman, Susan E.

AU - Weyemi, Urbain

PY - 2020

Y1 - 2020

N2 - While genomic instability and mitochondrial homeostasis are integral for cancer progression, how these two hallmarks interact remains poorly understood. Here, we reflect on the dialogue between chromatin-based genomic instability and impairment of mitochondrial function and depict the importance of this interaction in cancer progression to metastasis.

AB - While genomic instability and mitochondrial homeostasis are integral for cancer progression, how these two hallmarks interact remains poorly understood. Here, we reflect on the dialogue between chromatin-based genomic instability and impairment of mitochondrial function and depict the importance of this interaction in cancer progression to metastasis.

KW - Genomic instability

KW - cancer

KW - chromatin

KW - metabolism

KW - mitochondrial homeostasis

UR - http://www.scopus.com/inward/record.url?scp=85087855743&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85087855743&partnerID=8YFLogxK

U2 - 10.1080/23723556.2020.1771959

DO - 10.1080/23723556.2020.1771959

M3 - Comment/debate

C2 - 32944631

AN - SCOPUS:85087855743

SN - 2372-3556

JO - Molecular and Cellular Oncology

JF - Molecular and Cellular Oncology

M1 - 1771959

ER -

Genomic instability and mitochondrial homeostasis in cancer: does chromatin have a say?

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this