Genomic imbalances in human lung adenocarcinomas and squamous cell carcinomas

Jianming Pei, Binaifer R. Balsara, Wu Li, Samuel Litwin, Edward Gabrielson, Madelyn Feder, Jin Jen, Joseph R. Testa

Research output: Contribution to journalArticle

Abstract

Comparative genomic hybridization analysis was performed on 67 non-small-cell lung cancers (NSCLCs), including 32 squamous cell carcinomas (SCCs) and 35 adenocarcinomas (ACs), to identify differences in the patterns of genomic imbalance between these two histologic subtypes. Among the entire tumor set, the chromosome arms most often overrepresented were 1q, 3q, 5p, and 8q, each detected in 50-55% of cases. The most frequently underrepresented arms were 9q, 3p, 8p, and 17p. The number of imbalances was similar in SCCs and ACs (median number/case: 12 and 11, respectively). Moreover, many imbalances, such as gains of 1q, 5p, and 8q, occurred at a high frequency in both histologic subgroups. Several statistically significant differences, however, were found. The most prominent difference was gain of 3q24-qter, seen in 81% of SCCs compared with 31% of ACs (P

Original languageEnglish (US)
Pages (from-to)282-287
Number of pages6
JournalGenes Chromosomes and Cancer
Volume31
Issue number3
DOIs
StatePublished - 2001

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Squamous Cell Carcinoma
Adenocarcinoma
Comparative Genomic Hybridization
Non-Small Cell Lung Carcinoma
Chromosomes
Adenocarcinoma of lung
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Genetics

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Genomic imbalances in human lung adenocarcinomas and squamous cell carcinomas. / Pei, Jianming; Balsara, Binaifer R.; Li, Wu; Litwin, Samuel; Gabrielson, Edward; Feder, Madelyn; Jen, Jin; Testa, Joseph R.

In: Genes Chromosomes and Cancer, Vol. 31, No. 3, 2001, p. 282-287.

Research output: Contribution to journalArticle

Pei, J, Balsara, BR, Li, W, Litwin, S, Gabrielson, E, Feder, M, Jen, J & Testa, JR 2001, 'Genomic imbalances in human lung adenocarcinomas and squamous cell carcinomas', Genes Chromosomes and Cancer, vol. 31, no. 3, pp. 282-287. https://doi.org/10.1002/gcc.1145
Pei, Jianming ; Balsara, Binaifer R. ; Li, Wu ; Litwin, Samuel ; Gabrielson, Edward ; Feder, Madelyn ; Jen, Jin ; Testa, Joseph R. / Genomic imbalances in human lung adenocarcinomas and squamous cell carcinomas. In: Genes Chromosomes and Cancer. 2001 ; Vol. 31, No. 3. pp. 282-287.
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