Genomic evolution from primary breast carcinoma to distant metastasis: Few copy number changes of breast cancer related genes

Cathy B. Moelans, Petra van der Groep, Laurien D C Hoefnagel, Marc J. van de Vijver, Pieter Wesseling, Jelle Wesseling, Elsken van der Wall, Paul J. van Diest

Research output: Contribution to journalArticle

Abstract

Cancer initiation and progression is characterized by (epi)genetic aberrations. However, little is known about the changes that occur during breast cancer metastasis. In the present study, multiplex ligation-dependent probe amplification was used to compare copy numbers of 21 established oncogenes and tumor suppressor genes between 55 primary breast cancer samples and corresponding distant metastases. Distant breast cancer metastases generally showed similar gene copy number aberrations compared to their corresponding primary tumors. The few genes that showed differences between primary tumor and metastasis (PRDM14, MED1, CCNE1, TRAF4, MTDH, CDH1) have been implicated in the development of therapy resistance.

Original languageEnglish (US)
Pages (from-to)138-146
Number of pages9
JournalCancer Letters
Volume344
Issue number1
DOIs
StatePublished - Mar 1 2014
Externally publishedYes

Fingerprint

Neoplasm Genes
Breast Neoplasms
Neoplasm Metastasis
TNF Receptor-Associated Factor 4
Neoplasms
Gene Dosage
Multiplex Polymerase Chain Reaction
Tumor Suppressor Genes
Oncogenes
Genes
Therapeutics

Keywords

  • Breast cancer
  • Gene dosage
  • Metastases
  • MLPA

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Moelans, C. B., van der Groep, P., Hoefnagel, L. D. C., van de Vijver, M. J., Wesseling, P., Wesseling, J., ... van Diest, P. J. (2014). Genomic evolution from primary breast carcinoma to distant metastasis: Few copy number changes of breast cancer related genes. Cancer Letters, 344(1), 138-146. https://doi.org/10.1016/j.canlet.2013.10.025

Genomic evolution from primary breast carcinoma to distant metastasis : Few copy number changes of breast cancer related genes. / Moelans, Cathy B.; van der Groep, Petra; Hoefnagel, Laurien D C; van de Vijver, Marc J.; Wesseling, Pieter; Wesseling, Jelle; van der Wall, Elsken; van Diest, Paul J.

In: Cancer Letters, Vol. 344, No. 1, 01.03.2014, p. 138-146.

Research output: Contribution to journalArticle

Moelans, CB, van der Groep, P, Hoefnagel, LDC, van de Vijver, MJ, Wesseling, P, Wesseling, J, van der Wall, E & van Diest, PJ 2014, 'Genomic evolution from primary breast carcinoma to distant metastasis: Few copy number changes of breast cancer related genes', Cancer Letters, vol. 344, no. 1, pp. 138-146. https://doi.org/10.1016/j.canlet.2013.10.025
Moelans CB, van der Groep P, Hoefnagel LDC, van de Vijver MJ, Wesseling P, Wesseling J et al. Genomic evolution from primary breast carcinoma to distant metastasis: Few copy number changes of breast cancer related genes. Cancer Letters. 2014 Mar 1;344(1):138-146. https://doi.org/10.1016/j.canlet.2013.10.025
Moelans, Cathy B. ; van der Groep, Petra ; Hoefnagel, Laurien D C ; van de Vijver, Marc J. ; Wesseling, Pieter ; Wesseling, Jelle ; van der Wall, Elsken ; van Diest, Paul J. / Genomic evolution from primary breast carcinoma to distant metastasis : Few copy number changes of breast cancer related genes. In: Cancer Letters. 2014 ; Vol. 344, No. 1. pp. 138-146.
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