Genomic evolution from primary breast carcinoma to distant metastasis: Few copy number changes of breast cancer related genes

Cathy B. Moelans, Petra van der Groep, Laurien D.C. Hoefnagel, Marc J. van de Vijver, Pieter Wesseling, Jelle Wesseling, Elsken van der Wall, Paul J. van Diest

Research output: Contribution to journalArticle

Abstract

Cancer initiation and progression is characterized by (epi)genetic aberrations. However, little is known about the changes that occur during breast cancer metastasis. In the present study, multiplex ligation-dependent probe amplification was used to compare copy numbers of 21 established oncogenes and tumor suppressor genes between 55 primary breast cancer samples and corresponding distant metastases. Distant breast cancer metastases generally showed similar gene copy number aberrations compared to their corresponding primary tumors. The few genes that showed differences between primary tumor and metastasis (PRDM14, MED1, CCNE1, TRAF4, MTDH, CDH1) have been implicated in the development of therapy resistance.

Original languageEnglish (US)
Pages (from-to)138-146
Number of pages9
JournalCancer Letters
Volume344
Issue number1
DOIs
StatePublished - Mar 1 2014

Keywords

  • Breast cancer
  • Gene dosage
  • MLPA
  • Metastases

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Moelans, C. B., van der Groep, P., Hoefnagel, L. D. C., van de Vijver, M. J., Wesseling, P., Wesseling, J., van der Wall, E., & van Diest, P. J. (2014). Genomic evolution from primary breast carcinoma to distant metastasis: Few copy number changes of breast cancer related genes. Cancer Letters, 344(1), 138-146. https://doi.org/10.1016/j.canlet.2013.10.025