Genomic diversity among Vibrio cholerae O139 strains isolated in Bangladesh and India between 1992 and 1998

Shah M. Faruque, Manujendra N. Saha, [No Value] Asadulghani, Prasanta K. Bag, Rupak K. Bhadra, S. K. Bhattacharya, R. Bradley Sack, Yoshifumi Takeda, G. Balakrish Nair

Research output: Contribution to journalArticle

Abstract

In order to assess the extent of genomic diversity among Vibrio cholerae O139 strains, restriction fragment length polymorphisms in two genetic loci, rrn and ctx, were studied. Analysis of 144 strains isolated from different regions of Bangladesh and India between 1992 and 1998 revealed the presence of at least six distinct ribotypes (B-I through B-VI) of which three were new ribotypes, and one of these was represented by a nontoxigenic O139 strain. Strains of ribotypes B-I through B-V shared 11 different CTX genotypes (A through K). Antimicrobial resistance patterns of the strains varied independently of their ribotypes and CTX genotypes. Results of this study suggest that V. cholerae O139 is undergoing rapid genetic changes leading to the origination of new variants, and temporal changes in antimicrobial resistance patterns may be contributing to the selection of different variants. Copyright (C) 2000 Federation of European Microbiological Societies.

Original languageEnglish (US)
Pages (from-to)279-284
Number of pages6
JournalFEMS Microbiology Letters
Volume184
Issue number2
DOIs
Publication statusPublished - Mar 15 2000

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Keywords

  • Antibiotic resistance
  • CTX genotype
  • Genetic diversity
  • Ribotype
  • Vibrio cholerae O139

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Applied Microbiology and Biotechnology
  • Microbiology

Cite this

Faruque, S. M., Saha, M. N., Asadulghani, N. V., Bag, P. K., Bhadra, R. K., Bhattacharya, S. K., ... Nair, G. B. (2000). Genomic diversity among Vibrio cholerae O139 strains isolated in Bangladesh and India between 1992 and 1998. FEMS Microbiology Letters, 184(2), 279-284. https://doi.org/10.1016/S0378-1097(00)00060-4