Genomic disorders and neurocognitive impairment in pediatric CKD

Miguel Verbitsky, Amy J. Kogon, Matthew Matheson, Stephen R. Hooper, Craig S. Wong, Bradley A. Warady, Susan L. Furth, Ali G. Gharavi

Research output: Contribution to journalArticle

Abstract

Children with CKD are at increased risk for neurocognitive impairment, but whether neurocognitive dysfunction is solely attributable to impaired renal function is unclear. Data from the CKD in Children Study Chronic Kidney Disease in Children (CKiD) Study indicate that a subset of children with CKD have unsuspected genomic disorders that predispose them to organ malformations and neurocognitive impairment. We therefore tested whether the CKiD Study participants with genomic disorders had impaired neurocognitive performance at enrollment. Compared with noncarriers (n=389), children with genomic disorders (n=31) scored significantly poorer on allmeasures of intelligence, anxiety/depressive symptoms, and executive function (differences of 0.6-0.7 SD; P=1.2x10-3-2.4x10-4). These differences persisted after controlling for known modifiers, including low birth weight, maternal education, seizure disorder, kidney disease duration, and genetically defined ancestry. The deleterious effect of genomic disorders on neurocognitive function was significantly attenuated in offspring of mothers with higher education, indicating the potential for modification by genetic and/or environmental factors. These data indicate that impaired neurocognitive function in some children with CKD may be attributable to genetic lesions that affect both kidney and neurocognitive development. Early identification of genomic disorders may provide opportunity for early diagnosis and personalized interventions to mitigate the effect on neurocognitive function.

Original languageEnglish (US)
Pages (from-to)2303-2309
Number of pages7
JournalJournal of the American Society of Nephrology
Volume28
Issue number8
DOIs
StatePublished - Aug 1 2017
Externally publishedYes

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Pediatrics
Chronic Renal Insufficiency
Mothers
Kidney
Education
Executive Function
Kidney Diseases
Low Birth Weight Infant
Neurocognitive Disorders
Intelligence
Early Diagnosis
Epilepsy
Anxiety
Depression

ASJC Scopus subject areas

  • Nephrology

Cite this

Verbitsky, M., Kogon, A. J., Matheson, M., Hooper, S. R., Wong, C. S., Warady, B. A., ... Gharavi, A. G. (2017). Genomic disorders and neurocognitive impairment in pediatric CKD. Journal of the American Society of Nephrology, 28(8), 2303-2309. https://doi.org/10.1681/ASN.2016101108

Genomic disorders and neurocognitive impairment in pediatric CKD. / Verbitsky, Miguel; Kogon, Amy J.; Matheson, Matthew; Hooper, Stephen R.; Wong, Craig S.; Warady, Bradley A.; Furth, Susan L.; Gharavi, Ali G.

In: Journal of the American Society of Nephrology, Vol. 28, No. 8, 01.08.2017, p. 2303-2309.

Research output: Contribution to journalArticle

Verbitsky, M, Kogon, AJ, Matheson, M, Hooper, SR, Wong, CS, Warady, BA, Furth, SL & Gharavi, AG 2017, 'Genomic disorders and neurocognitive impairment in pediatric CKD', Journal of the American Society of Nephrology, vol. 28, no. 8, pp. 2303-2309. https://doi.org/10.1681/ASN.2016101108
Verbitsky M, Kogon AJ, Matheson M, Hooper SR, Wong CS, Warady BA et al. Genomic disorders and neurocognitive impairment in pediatric CKD. Journal of the American Society of Nephrology. 2017 Aug 1;28(8):2303-2309. https://doi.org/10.1681/ASN.2016101108
Verbitsky, Miguel ; Kogon, Amy J. ; Matheson, Matthew ; Hooper, Stephen R. ; Wong, Craig S. ; Warady, Bradley A. ; Furth, Susan L. ; Gharavi, Ali G. / Genomic disorders and neurocognitive impairment in pediatric CKD. In: Journal of the American Society of Nephrology. 2017 ; Vol. 28, No. 8. pp. 2303-2309.
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