Genomic changes associated with antigenic variation of visna virus. II. Common nucleotide sequence changes detected in variants from independent isolations

Janice E. Clements, Nancy D'Antonio, Opendra Narayan

Research output: Contribution to journalArticlepeer-review

Abstract

Naturally occurring antigenic variants of visna virus isolated from two persistently infected sheep have been compared using RNAase T1 fingerprint analysis of the viral RNAs. All the viruses examined have oligonucleotide changes in the 3′-terminal region of the viral genome and many of the alterations are common among the variants of both sheep. There is progressive accumulation of point mutations in the 3′-terminal region of antigenically altered viruses isolated from persistently infected animals. In addition, antigenic variants isolated independently from another sheep contain the same altered oligonucleotides; the nucleotide sequences of these oligonucleotides are identical. These data strongly suggest that the alterations observed in the nucleotide sequence of the variants are related to the change in their antigenic character.

Original languageEnglish (US)
Pages (from-to)415-434
Number of pages20
JournalJournal of molecular biology
Volume158
Issue number3
DOIs
StatePublished - Jul 5 1982

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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